High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation or autologous bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells.

PURPOSE: This phase II trial is studying how well eight different high-dose chemotherapy regimens with or without total-body irradiation followed by autologous stem cell transplantation or autologous bone marrow transplantation works in treating patients with hematologic malignancies or solid tumors.

Conditions

• Breast Cancer
• Leukemia
• Lymphoma
• Multiple Myeloma and Plasma Cell Neoplasm
• Testicular Germ Cell Tumor
• Unspecified Adult Solid Tumor, Protocol Specific
• Unspecified Childhood Solid Tumor, Protocol Specific

Interventions

DRUG

busulfan

iv

DRUG

carboplatin

iv

DRUG

carmustine

iv

DRUG

cyclophosphamide

iv

DRUG

etoposide

iv

DRUG

melphalan

oral

DRUG

thiotepa

iv

PROCEDURE

autologous bone marrow transplantation

iv

PROCEDURE

bone marrow ablation with stem cell support

iv

PROCEDURE

peripheral blood stem cell transplantation

iv

RADIATION

radiation therapy

body x-ray

Sponsors & Collaborators

• Roswell Park Cancer Institute

  lead OTHER

Principal Investigators

• Philip L. McCarthy, MD · Roswell Park Cancer Institute

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

4 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1991-12-31

Primary Completion

2006-08-31

Completion

2013-02-28

Countries

• United States

Study Locations