Combination Chemotherapy and Bone Marrow Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome
NCT00002502 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL
Last updated 2013-06-27
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy consisting of busulfan and cyclophosphamide followed by bone marrow transplantation in treating patients who have acute or chronic leukemia or myelodysplastic syndrome.
Conditions
- Leukemia
- Lymphoma
- Multiple Myeloma and Plasma Cell Neoplasm
- Myelodysplastic Syndromes
Interventions
- DRUG
-
busulfan
- DRUG
- DRUG
- PROCEDURE
-
allogeneic bone marrow transplantation
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Memorial Sloan Kettering Cancer Center
lead OTHER
Principal Investigators
-
Esperanza B. Papadopoulos, MD · Memorial Sloan Kettering Cancer Center
Study Design
- Purpose
- TREATMENT
Eligibility
- Max Age
- 55 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1992-07-31
- Primary Completion
- 2000-05-31
- Completion
- 2000-05-31
Countries
- United States
Study Locations
More Related Trials
-
Busulfan, Cyclophosphamide, and Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma
NCT00941720 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia or Myelodysplastic Syndrome
NCT00027924 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous or Acute Leukemia
NCT00002831 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Melphalan and Busulfan Followed By Donor Peripheral Stem Cell Transplant, Tacrolimus, and Methotrexate in Treating Patients With Multiple Myeloma
NCT00313625 ·Status: COMPLETED ·Phase: PHASE2
-
S9920 Busulfan Compared With Cyclophosphamide in Patients Undergoing Total-Body Irradiation Plus Peripheral Stem Cell Transplantation for Advanced Myelodysplastic Syndrome or Related Acute Myeloid Leukemia
NCT00005866 ·Status: COMPLETED ·Phase: PHASE3
-
Chemotherapy and Biological Therapy With or Without Bone Marrow or Peripheral Stem Cell Transplant in Treating Patients With Chronic Myelogenous Leukemia
NCT00025402 ·Status: UNKNOWN ·Phase: PHASE3
-
Chemotherapy Plus Bone Marrow Transplantation and Filgrastim in Treating Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
NCT00004899 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma
NCT00003146 ·Status: COMPLETED ·Phase: PHASE2
-
Busulfan, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk Ewing's Tumors
NCT00357396 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Total-Body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia
NCT00027547 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
High-Dose Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Poor-Prognosis Breast Cancer
NCT00002509 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer
NCT00003270 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Acute Leukemia
NCT00008190 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma
NCT00002552 ·Status: COMPLETED ·Phase: PHASE2
-
High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors
NCT00060255 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors
NCT00002594 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer
NCT00003816 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Total-Body Irradiation, Cyclophosphamide, and Stem Cell Transplantation in Treating Patients With Hematologic Cancer
NCT00062140 ·Status: COMPLETED ·Phase: PHASE1
-
Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Myelofibrosis
NCT00006367 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia
NCT00002674 ·Status: COMPLETED ·Phase: PHASE2
-
Bone Marrow Transplantation in Treating Patients With Chronic Lymphocytic Leukemia
NCT00002844 ·Status: COMPLETED ·Phase: PHASE2
-
Peripheral Stem Cell Transplantation in Treating Patients With Melanoma or Small Cell Lung, Breast, Testicular, or Kidney Cancer That is Metastatic or That Cannot Be Treated With Surgery
NCT00006126 ·Status: WITHDRAWN ·Phase: PHASE1
-
Total-Body Irradiation and Chemotherapy Followed By Donor Bone Marrow Transplant in Treating Young Patients With Hematologic Cancer
NCT00028730 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma
NCT00002521 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy Plus Radiation Therapy and Biological Therapy in Treating Patients With Hematologic Cancer
NCT00002553 ·Status: COMPLETED ·Phase: PHASE2