SWOG-9416: Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Stage III Non-small Cell Lung Cancer

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to kill tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of chemotherapy using cisplatin and etoposide, radiation therapy, and surgery, with adjuvant therapy using cisplatin and etoposide, in treating patients who have stage III non-small cell lung cancer.

Conditions

• Lung Cancer

Interventions

DRUG

cisplatin

50 mg/m2, IV Days 1 and 8, two 28 day cycles prior to surgery and two 28 day cycles after surgery

DRUG

etoposide

50 mg/m2, IV Days 1-5, two 28 day cycles prior to surgery and two 28 day cycles after surgery

PROCEDURE

conventional surgery

surgery some time between weeks 9 and 12

RADIATION

low-LET cobalt-60 gamma ray therapy

180 cGy per day, Days 1-5, weekly for 5 weeks

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• Eastern Cooperative Oncology Group

  collaborator NETWORK

• Cancer and Leukemia Group B

  collaborator NETWORK

• NCIC Clinical Trials Group

  collaborator NETWORK

• North Central Cancer Treatment Group

  collaborator NETWORK

• SWOG Cancer Research Network

  lead NETWORK

Principal Investigators

• Valerie W. Rusch, MD, FACS · Memorial Sloan Kettering Cancer Center

• David H. Johnson, MD · Vanderbilt-Ingram Cancer Center

• Lawrence N. Shulman, MD · Dana-Farber Cancer Institute

• Ronald L. Burkes, MD, FRCPC · Mount Sinai Hospital, Canada

• Claude Deschamps, MD · Mayo Clinic

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1995-04-30

Primary Completion

2001-01-31

Completion

2004-07-31

Countries

• United States

Study Locations