Chemotherapy Plus Radiation Therapy With or Without Surgery in Treating Patients With Stage IIIA Non-small Cell Lung Cancer

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known if chemotherapy plus radiation therapy is more effective with or without surgery for lung cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of combining cisplatin, etoposide, and radiation therapy with or without surgery in treating patients who have stage IIIA non-small cell lung cancer.

Conditions

• Lung Cancer

Interventions

DRUG

cisplatin

DRUG

etoposide

PROCEDURE

conventional surgery

RADIATION

radiation therapy

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• SWOG Cancer Research Network

  collaborator NETWORK

• Eastern Cooperative Oncology Group

  collaborator NETWORK

• Cancer and Leukemia Group B

  collaborator NETWORK

• North Central Cancer Treatment Group

  collaborator NETWORK

• NCIC Clinical Trials Group

  collaborator NETWORK

• Radiation Therapy Oncology Group

  lead NETWORK

Principal Investigators

• David S. Ettinger, MD · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

• Kathy S. Albain, MD · Loyola University

• David H. Johnson, MD · Vanderbilt-Ingram Cancer Center

• Bruce E. Johnson, MD · Dana-Farber Cancer Institute

• Mark R. Green, MD · Medical University of South Carolina

• Robert C. Miller, MD · Mayo Clinic

• Yvon Cormier, MD · L'Hopital Laval

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1994-03-31

Primary Completion

2004-06-30

Completion

2013-11-30

Countries

• United States
• South Africa

Study Locations