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Systolic Hypertension in the Elderly Program (SHEP) (Pilot Study)

NCT00000499 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2013-11-26

No results posted yet for this study

Summary

The SHEP Pilot Study had six objectives, each designed to develop and test critical components of a full scale trial directed at the health consequences of treating isolated systolic hypertension (ISH) in the elderly.

l. To estimate and compare the yield of participants for randomization into a clinical trial from various community groups using various recruitment techniques.

2\. To estimate compliance with the visit schedule and to the prescribed double-blind regimens.

3\. To estimate and compare the effectiveness of specified antihypertensive medications in reducing the blood pressure.

4\. To estimate and compare the unwanted effects of specified antihypertensive medication in an elderly population.

5\. To evaluate the feasibility and effectiveness of periodic behavioral assessment in this population.

6\. To develop and test methods of ascertaining stroke and other disease endpoints.

Conditions

Interventions

DRUG

chlorthalidone

DRUG

reserpine

DRUG

hydralazine

DRUG

metoprolol

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • National Heart, Lung, and Blood Institute (NHLBI)

    lead NIH

Principal Investigators

  • Merwyn Greenlick · Kaiser Foundation Research Institute

  • Robert McDonald · University of Pittsburgh

  • H. Perry · Washington University School of Medicine

  • Harold Schnaper · University of Alabama at Birmingham

  • James Schoenberger · Rush University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1980-09-30
Completion
1983-05-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00000499 on ClinicalTrials.gov