Also known as: Tracleer
Bosentan is an oral dual endothelin receptor antagonist used primarily for pulmonary arterial hypertension. It is marketed under names including Tracleer and is also used to reduce digital ulcers in systemic sclerosis. The medicine is prescription-only and has been approved in the U.S. since 2001.
Zydus Lifesciences received USFDA final approval for 32 mg bosentan tablets for pediatric PAH and Ammonium Lactate Cream, 12%, while launching an affordable respiratory device in India.
DelveInsight releases three separate pipeline reports covering metastatic prostate cancer (80+ companies, 85+ drugs), iPSC-derived NK cells (12+ companies, 15+ drugs), and interstitial lung diseases (120+ companies, 120+ drugs), highlighting recent regulatory approvals, trial launches, and emerging therapies.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07081932 |
A Study in Healthy Men to Test How Bosentan Influences the Amount of Nerandomilast in the Blood |
COMPLETED | PHASE1 |
| NCT06957002 |
Bosentan in the Treatment of Giant Cell Arteritis |
NOT_YET_RECRUITING | PHASE2 |
| NCT05723874 |
A Study in Healthy Men to Test Whether Bosentan Influences the Amount of BI 425809 in the Blood |
COMPLETED | PHASE1 |
| NCT05072106 |
Study to Evaluate the Effect of Bosentan on the Pharmacokinetics of Lurbinectedin in Patients With Advanced Solid Tumors |
COMPLETED | PHASE1 |
| NCT04991207 |
Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of Bosentan |
COMPLETED | PHASE1 |
| NCT04388124 |
Endothelin-1 Receptor Blockade in Resistant Hypertension |
RECRUITING | PHASE2 |
| NCT04158635 |
Gemcitabine, Nab-Paclitaxel, and Bosentan for the Treatment of Unresectable Pancreatic Cancer |
RECRUITING | PHASE1 |
| NCT04068272 |
Safety of Bosentan in Type II Diabetic Patients |
COMPLETED | PHASE1 |
| NCT02667704 |
Influence of Bosentan on the Pharmacokinetics of Nintedanib |
COMPLETED | PHASE1 |
| NCT02480335 |
The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis |
COMPLETED | PHASE4 |
