A Study in Healthy Men to Test How Bosentan Influences the Amount of Zongertinib in the Blood
NCT07649941 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 16
Last updated 2026-07-27
Summary
The main objective of this trial is to investigate the effect of a moderate CYP 3A inducer bosentan on the pharmacokinetics of zongertinib.
Conditions
- Healthy
Interventions
- DRUG
-
Zongertinib
Zongertinib
- DRUG
-
Bosentan
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 25 Years
- Max Age
- 55 Years
- Sex
- MALE
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2026-06-22
- Primary Completion
- 2026-08-19
- Completion
- 2026-08-19
Countries
- Germany
Study Locations
More Related Trials
-
A Study in Healthy Men to Test How Well Different Doses of BI 3821001 Are Tolerated
NCT07526194 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 706321
NCT03971695 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy Men to Test How Well Different Doses of BI 1569912 Are Tolerated
NCT04978506 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy Men Tests How Different Doses of BI 764198 Are Taken up in the Body and How Well They Are Tolerated.
NCT03854552 ·Status: COMPLETED ·Phase: PHASE1
-
This Study in Healthy Men Tests How Different Doses of BI 1265162 Are Taken up in the Body and How Well They Are Tolerated.
NCT03576144 ·Status: COMPLETED ·Phase: PHASE1
-
This Study in Healthy Men Tests How Different Doses of BI 1323495 Are Taken up in the Body and How Well They Are Tolerated.
NCT03588390 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Test How Well Different Doses of BI 3810477 Are Tolerated by Healthy Men
NCT06631430 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Explore Pharmacokinetics and Pharmacodynamics of a Single Rising Dose of BI 135585 XX
NCT01652742 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 60732 in Healthy Male Volunteers
NCT02244203 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy Men to Test How Well Different Doses of BI 3731579 Are Tolerated
NCT06429137 ·Status: COMPLETED ·Phase: PHASE1
-
This Study in Healthy Men Tests How Different Doses of BI 894416 Are Taken up in the Body and How Well BI 894416 is Tolerated
NCT03315936 ·Status: COMPLETED ·Phase: PHASE1
-
This Study Tests How Healthy Men Tolerate Different Doses of BI1015550. The Study Also Tests How BI 1015550 is Taken up by the Body
NCT03230487 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Tolerability of BI 685509 in Healthy Subjects
NCT03116906 ·Status: COMPLETED ·Phase: PHASE1
-
This Study Tests How Different Doses of BI 1291583 Are Taken up in the Body and How Well They Are Tolerated
NCT03414008 ·Status: TERMINATED ·Phase: PHASE1
-
A Study to Test How Well Different Doses of BI 1815368 Are Tolerated by Healthy Men
NCT05857878 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability and Pharmacokinetics of Multiple Rising Oral Doses of BI 1015550 Powder for Oral Solution
NCT01835899 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Test How Well Men Tolerate Different Doses of BI 3006337
NCT05076422 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy Men to Test How Well Different Doses of BI 1839100 Are Tolerated (1490-0003)
NCT05934955 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy Men to Test How BI 1015550 is Taken up and Handled by the Body
NCT05707403 ·Status: COMPLETED ·Phase: PHASE1
-
This Study Tests the Safety, Tolerability and How Different Doses of BI 1265162 Are Taken up in the Body of Healthy Men
NCT03349723 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy Men to Test How the Body Takes up and Tolerates Different Doses of BI 765080
NCT04666922 ·Status: COMPLETED ·Phase: PHASE1
-
To Assess Safety, Tolerability and Pharmacokinetics of BI 730357 in Healthy Male Volunteers
NCT03004404 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Oral Doses of BI 10773 in Healthy Male Subjects
NCT02172170 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Test How Well Different Doses of BI 1584862 Are Tolerated by Healthy Men
NCT06006598 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy Men to Find Out How Different Doses of BI 3009947 Are Tolerated and How Different Formulations or Food Influence How BI 3009947 is Taken up Into the Blood
NCT07250048 ·Status: TERMINATED ·Phase: PHASE1