Two neuroscience studies reveal brain mechanisms behind anxiety and compulsive behavior. One found restoring balance in an amygdala circuit reversed anxiety in mice, while another showed inflammation in the striatum makes behavior more deliberate.
New clinical trials show single doses of psilocybin and LSD produce significant, lasting reductions in OCD and generalized anxiety disorder symptoms for up to 12 weeks, marking a potential shift from daily medication regimens.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07774481 |
Anxiety Skills Study |
RECRUITING | NA |
| NCT07704632 |
Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Treatment Refractory Obsessive Compulsive Disorder (OCD) |
RECRUITING | NA |
| NCT07701616 |
Digital Mindfulness-Based Therapy for Obsessive-Compulsive Disorder |
RECRUITING | NA |
| NCT07570108 |
Precision Brain Mapping to Predict and Track Response to Exposure and Response Prevention Therapy in Youth With Obsessive-Compulsive Disorder |
WITHDRAWN | NA |
| NCT07347405 |
Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder. |
RECRUITING | PHASE1 |
| NCT07158801 |
Project EMPOWER-OCD |
RECRUITING | NA |
| NCT07111988 |
Valbenazine in Obsessive Compulsive Disorder |
NOT_YET_RECRUITING | PHASE2 |
| NCT06993662 |
The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective. |
COMPLETED | PHASE1 |
| NCT06754319 |
Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis |
RECRUITING | |
| NCT06575075 |
Pilot Study of RR-HNK in OCD |
RECRUITING | PHASE1/PHASE2 |
