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Heading in Football: Impact on Neural Blood Biomarkers

NCT06147596 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 335

Last updated 2025-05-13

No results posted yet for this study

Summary

The goal of this observational study is to evaluate the safety of heading in football. We will study the release of biomarkers in blood that reflect microscopic neural damage. The main questions this study aims to answer are:

* Does participation in a football match lead to a change in biomarkers that reflect microscopic neural damage?
* Is the dose of exposure during a football match related to the magnitude of change in biomarkers that reflect microscopic neural damage?

Participants will participate in a regular football match and provide blood samples before and right after the football match. The football match will be recorded on video to count the number of headers of all participants.

Conditions

  • Head Injury, Minor
  • Concussion, Mild
  • CTE - Chronic Traumatic Encephalopathy
  • Neurodegeneration

Interventions

OTHER

Head impact exposure

The cohort is exposed to naturalistic head impacts (heading) during voluntary participation in a soccer match. All participants are regular soccer players and are therefore not exposed to excessive head impacts compared to their regular exposure.

Sponsors & Collaborators

  • Koninklijke Nederlandse VoetbalBond (KNVB)

    collaborator UNKNOWN

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    lead OTHER

Principal Investigators

  • Jaap Oosterlaan, Prof.Dr. · Amsterdam UMC

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-13
Primary Completion
2024-12-17
Completion
2024-12-17

Countries

  • Netherlands

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06147596 on ClinicalTrials.gov