A real-world study in Galicia showed nirsevimab reduced RSV-related hospitalizations by 85.9% in the first season and 55.3% in the second. The RSV prevention market is expanding to cover high-risk children, with Beyfortus the only antibody approved for second-season use. The FDA has cited Sanofi for misleading promotional claims about the product.
A study from the University of Osaka identified the integrin αV–YAP–CTGF pathway linking chronic liver congestion to fibrosis. The findings point to a potential therapeutic target in congestion-related liver disease.
The European Commission approved Enflonsia for prevention of RSV lower respiratory tract disease in infants during their first RSV season. Merck also reported new Phase 3 SMART data showing generally consistent second-season safety in high-risk children under 2 years old.
Merck announced positive second RSV season findings from the Phase 3 SMART trial evaluating ENFLONSIA (clesrovimab) in infants and children under 2 years at increased risk for severe RSV disease, showing consistent safety and antibody levels similar to healthy infants.
| NCT ID | Title | Status | Phase |
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Localized Evidence of Cytokine Adsorption Therapy During Pediatric Cardiac Surgery: A Single Center Randomized Controlled Trial (LEAT) |
NOT_YET_RECRUITING | NA |
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ENROLLING_BY_INVITATION | NA |
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RECRUITING | |
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ENROLLING_BY_INVITATION | NA |
| NCT07732244 |
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RECRUITING | NA |
| NCT07716488 |
Screening for Disorders of Lipid Metabolism and Familial Hyperlipidemia in Children and Adolescents With Increased Cardiovascular Risk Due to Chronic Diseases Such as Congenital Heart Disease, Chronic Inflammatory Bowel Disease, Celiac Disease and Rheumatic Disorders |
RECRUITING | NA |
| NCT07706140 |
Observational Data Collection for Blood Hemoglobin Algorithm Validation in Pediatrics |
NOT_YET_RECRUITING | |
| NCT07700459 |
Exercise Prehabilitation in Congenital Heart Disease |
NOT_YET_RECRUITING | NA |
| NCT07697755 |
Interoceptive Intervention for Congenital Heart Disease |
NOT_YET_RECRUITING | NA |
| NCT07663799 |
Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance Trial Prospective |
NOT_YET_RECRUITING |
