Clinical Trials

NCT04886518 | COMPLETED | PHASE2

30 participants

Safety and Efficacy of Pitolisant on Excessive Daytime Sleepiness and Other Non-Muscular Symptoms in Patients With Myotonic Dystrophy Type 1

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-06-28

Completion:

2023-10-06

Conditions

• Myotonic Dystrophy 1
• Excessive Daytime Sleepiness

Interventions

• DRUG

Results Available

NCT04858334 | RECRUITING | PHASE2

152 participants

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-06-22

Completion:

2027-10-31

Conditions

• Pancreatic Acinar Cell Carcinoma
• Pancreatic Adenosquamous Carcinoma
• Pancreatic Squamous Cell Carcinoma
• Resectable Pancreatic Acinar Cell Carcinoma
• Resectable Pancreatic Adenocarcinoma
• Resectable Pancreatic Adenosquamous Carcinoma
• Resectable Pancreatic Carcinoma

Interventions

• PROCEDURE
• DRUG

No Results Yet

NCT04837586 | COMPLETED | NA

102 participants

Self-Weighing for Adolescents Seeking Obesity Treatment

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2023-09-15

Completion:

2024-06-26

Conditions

• Adolescent Obesity

Interventions

• OTHER
• DEVICE

No Results Yet

NCT04822181 | ACTIVE_NOT_RECRUITING | PHASE3

1205 participants

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-04-01

Completion:

2029-04-25

Conditions

• Non-alcoholic Steatohepatitis

Interventions

• DRUG

No Results Yet

NCT04821622 | ACTIVE_NOT_RECRUITING | PHASE3

599 participants

Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-05-12

Completion:

2026-02-18

Conditions

• Prostate Cancer

Interventions

• DRUG

No Results Yet

NCT04815356 | RECRUITING | PHASE1

27 participants

Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients With Relapsed/Refractory Hairy Cell Leukemia and Variant

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2022-05-23

Completion:

2036-12-01

Conditions

• Hairy Cell Leukemia
• Hairy Cell Leukemia Variant

Interventions

• BIOLOGICAL

No Results Yet

NCT04787640 | COMPLETED

3 participants

Wear and Tear Evaluation of New Nike Sport Sole for Runnnig Prosthesis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-02-20

Completion:

2021-02-03

Conditions

• Lower Limb Amputation Below Knee (Injury)

Interventions

• DEVICE

Results Available

NCT04787484 | COMPLETED

18 participants

IceExplore TF Liner Alpha Investigation

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-10-05

Completion:

2021-11-30

Conditions

• Prostheses and Implants

Interventions

• DEVICE

Results Available

NCT04777331 | ACTIVE_NOT_RECRUITING | PHASE2

586 participants

A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-05-05

Completion:

2024-09-11

Conditions

• Parkinsons Disease

Interventions

• DRUG

Results Available

NCT04760717 | ACTIVE_NOT_RECRUITING | PHASE2

160 participants

Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage and Ischemic Stroke

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-03-19

Completion:

2026-02-02

Conditions

• Intracerebral Hemorrhage
• Ischemic Stroke
• Spironolactone

Interventions

• DRUG

No Results Yet

NCT04746235 | ACTIVE_NOT_RECRUITING | PHASE2

85 participants

Venetoclax and ASTX727 for the Treatment of Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-02-22

Completion:

2026-10-31

Conditions

• Acute Myeloid Leukemia
• Recurrent Acute Myeloid Leukemia
• Refractory Acute Myeloid Leukemia

Interventions

• DRUG

No Results Yet

NCT04707248 | ACTIVE_NOT_RECRUITING | PHASE1

179 participants

A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-12-22

Completion:

2026-12-30

Conditions

• Renal Cell Carcinoma
• Ovarian Tumor

Interventions

• DRUG

No Results Yet

NCT04704661 | ACTIVE_NOT_RECRUITING | PHASE1

51 participants

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-08-09

Completion:

2027-03-31

Conditions

• Advanced Breast Carcinoma
• Advanced Colon Carcinoma
• Advanced Colorectal Carcinoma
• Advanced Endometrial Carcinoma
• Advanced Gastric Carcinoma
• Advanced Gastroesophageal Junction Adenocarcinoma
• Advanced Malignant Solid Neoplasm
• Advanced Salivary Gland Carcinoma
• Anatomic Stage III Breast Cancer AJCC v8
• Anatomic Stage IV Breast Cancer AJCC v8
• Clinical Stage III Gastric Cancer AJCC v8
• Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage IV Gastric Cancer AJCC v8
• Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
• HER2-Positive Breast Carcinoma
• Malignant Hepatobiliary Neoplasm
• Metastatic Breast Carcinoma
• Metastatic Colon Carcinoma
• Metastatic Colorectal Carcinoma
• Metastatic Endometrial Carcinoma
• Metastatic Gastric Carcinoma
• Metastatic Gastroesophageal Junction Adenocarcinoma
• Metastatic Malignant Solid Neoplasm
• Metastatic Salivary Gland Carcinoma
• Stage III Colon Cancer AJCC v8
• Stage III Colorectal Cancer AJCC v8
• Stage III Major Salivary Gland Cancer AJCC v8
• Stage III Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
• Stage IV Colon Cancer AJCC v8
• Stage IV Colorectal Cancer AJCC v8
• Stage IV Major Salivary Gland Cancer AJCC v8
• Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
• Unresectable Breast Carcinoma
• Unresectable Colon Carcinoma
• Unresectable Colorectal Carcinoma
• Unresectable Endometrial Carcinoma
• Unresectable Gastric Carcinoma
• Unresectable Gastroesophageal Junction Adenocarcinoma
• Unresectable Malignant Solid Neoplasm
• Unresectable Salivary Gland Carcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04701684 | RECRUITING | NA

594 participants

WE-TRUST (Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-06-23

Completion:

2027-04-01

Conditions

• Stroke, Acute

Interventions

• DEVICE
• PROCEDURE

No Results Yet

NCT04680052 | ACTIVE_NOT_RECRUITING | PHASE3

654 participants

A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-04-15

Completion:

2024-02-23

Conditions

• Follicular Lymphoma
• Marginal Zone Lymphoma

Interventions

• DRUG

Results Available

NCT04661787 | COMPLETED

36 participants

Donation Advisor Clinical Decision Support Tool Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-04

Start Date:

2021-01-11

Completion:

2023-08-31

Conditions

• Organ Donation

No Results Yet

NCT04655755 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

52 participants

Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-01-19

Completion:

2028-07-20

Conditions

• Chronic Myelomonocytic Leukemia
• Myelodysplastic Syndrome

Interventions

• DRUG

No Results Yet

NCT04647435 | COMPLETED | PHASE3

396 participants

Efficacy and Safety of APSCTC for the Treatment of Postsurgical Pain Due to Third Molar Extraction

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2023-05-13

Completion:

2024-10-04

Conditions

• Postsurgical Pain
• Third Molar Extraction

Interventions

• DRUG

No Results Yet

NCT04626362 | COMPLETED | NA

55 participants

American Cranberries to Prevent UTIs in Susceptible Women

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-02-02

Completion:

2026-08-20

Conditions

• Healthy

Interventions

• OTHER

No Results Yet

NCT04612803 | WITHDRAWN | PHASE3

0 participants

Antihistamines in the Treatment of Irritable Bowel Syndrome With Diarrhea

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-02-01

Completion:

2026-08-31

Conditions

• Irritable Bowel Syndrome
• Dermatographism
• Post-prandial Diarrhea

Interventions

• DRUG

No Results Yet

NCT04609046 | ACTIVE_NOT_RECRUITING | PHASE1

47 participants

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-05-24

Completion:

2027-04-01

Conditions

• Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04599192 | ACTIVE_NOT_RECRUITING

500 participants

Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-04

Start Date:

2019-04-19

Completion:

2028-08-31

Conditions

• Coronary Disease
• Percutaneous Coronary Intervention
• Exercise Test
• Myocardial Perfusion Imaging
• Cardiac Catheterization

Interventions

• OTHER

No Results Yet

NCT04597359 | ACTIVE_NOT_RECRUITING | PHASE2

360 participants

To Evaluate if Green Tea Can be Effective in Reducing the Progression of Prostate Cancer in Men on Close Monitoring

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-10-05

Completion:

2026-12-31

Conditions

• Prostate Carcinoma

Interventions

• DRUG
• OTHER

No Results Yet

NCT04589845 | ACTIVE_NOT_RECRUITING | PHASE2

920 participants

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-01-18

Completion:

2032-09-25

Conditions

• Solid Tumors

Interventions

• DRUG

No Results Yet

NCT04574518 | ACTIVE_NOT_RECRUITING | NA

223 participants

Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2022-08-12

Completion:

2026-03-31

Conditions

• Solitary Pulmonary Nodule
• Multiple Pulmonary Nodules
• Tobacco Use

Interventions

• BEHAVIORAL

No Results Yet

NCT04447911 | RECRUITING | PHASE4

113 participants

Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-02-04

Completion:

2026-09-15

Conditions

• Hyponatremia
• SIADH
• Liver Failure
• Kidney Failure

Interventions

• DRUG

No Results Yet

NCT04447183 | COMPLETED | PHASE2

123 participants

rhTSH for Radioactive Iodine Remnant Ablation in Differentiated Thyroid Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-11-23

Completion:

2022-05-31

Conditions

• Differentiated Thyroid Cancer

Interventions

• DRUG
• OTHER

No Results Yet

NCT04429087 | ACTIVE_NOT_RECRUITING | PHASE1

300 participants

A Study to Test Different Doses of Obrixtamig in Patients With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for DLL3

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-07-29

Completion:

2026-08-31

Conditions

• Small Cell Lung Carcinoma and Other Neuroendocrine Neoplasms Expressing DLL3

Interventions

• DRUG

No Results Yet

NCT04427527 | COMPLETED | NA

29772 participants

Accelerating Colorectal Cancer Screening Through Implementation Science in Appalachia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-08-19

Completion:

2025-03-31

Conditions

• Colorectal Cancer

Interventions

• BEHAVIORAL

Results Available

NCT04409236 | ACTIVE_NOT_RECRUITING | NA

427 participants

Quit2Heal Smartphone App in Helping Cancer Patients Quit Smoking

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-07-19

Completion:

2025-09-11

Conditions

• Hematopoietic and Lymphoid System Neoplasm
• Malignant Solid Neoplasm

Interventions

• BEHAVIORAL
• OTHER

Results Available

NCT04402788 | SUSPENDED | PHASE2/PHASE3

138 participants

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-01-07

Completion:

2027-04-30

Conditions

• Extensive Stage Lung Small Cell Carcinoma

Interventions

• DRUG
• PROCEDURE
• RADIATION

No Results Yet

NCT04391049 | ACTIVE_NOT_RECRUITING | PHASE1

16 participants

Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-12-02

Completion:

2024-10-06

Conditions

• Advanced Esophageal Adenocarcinoma
• Advanced Gastroesophageal Junction Adenocarcinoma
• Clinical Stage II Esophageal Adenocarcinoma AJCC v8
• Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8
• Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8
• Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage III Esophageal Adenocarcinoma AJCC v8
• Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage II Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage III Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Unresectable Gastroesophageal Junction Adenocarcinoma
• Squamous Cell Carcinoma
• Squamous Cell Cancer

Interventions

• DRUG
• RADIATION
• BIOLOGICAL

Results Available

NCT04367246 | RECRUITING

300 participants

Li-Fraumeni Syndrome/TP53 Biobank

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-04

Start Date:

2019-09-24

Completion:

2029-09-24

Conditions

• Li-Fraumeni Syndrome
• Li-Fraumeni-Like Syndrome

Interventions

• OTHER

No Results Yet

NCT04340141 | ACTIVE_NOT_RECRUITING | PHASE3

358 participants

Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-10-13

Completion:

2028-12-31

Conditions

• Pancreatic Adenosquamous Carcinoma
• Resectable Pancreatic Adenocarcinoma
• Stage I Pancreatic Cancer AJCC v8
• Stage II Pancreatic Cancer AJCC v8
• Stage III Pancreatic Cancer AJCC v8

Interventions

• DRUG
• PROCEDURE
• OTHER

No Results Yet

NCT04315233 | TERMINATED | PHASE1

12 participants

Ribociclib&Belinostat In Patients w Metastatic Triple Neg Breast Cancer & Recurrent Ovarian Cancer w Response Prediction By Genomics

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-05-03

Completion:

2024-03-14

Conditions

• Metastatic Breast Cancer
• Recurrent Ovarian Carcinoma

Interventions

• DRUG

Results Available

NCT04269902 | RECRUITING | PHASE3

247 participants

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2021-03-02

Completion:

2028-10-01

Conditions

• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma

Interventions

• PROCEDURE
• BIOLOGICAL
• OTHER
• DRUG

No Results Yet

NCT04267848 | RECRUITING | PHASE3

1210 participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-06-16

Completion:

2027-01-31

Conditions

• Lung Non-Small Cell Carcinoma
• Lung Non-Small Cell Squamous Carcinoma
• Lung Non-Squamous Non-Small Cell Carcinoma
• Stage II Lung Cancer AJCC v8
• Stage IIIA Lung Cancer AJCC v8
• Stage IIIB Lung Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• OTHER
• BIOLOGICAL

No Results Yet

NCT04254185 | ACTIVE_NOT_RECRUITING | NA

378 participants

Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-02-18

Completion:

2027-10-31

Conditions

• Neuropathy Ulnar

Interventions

• PROCEDURE

No Results Yet

NCT04250116 | COMPLETED | PHASE4

960 participants

Appropriate Duration of Anti-Platelet and Thrombotic Strategy After 12 Months in Patients With Atrial Fibrillation Treated With Drug Eluting Stents

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-04-28

Completion:

2026-05-08

Conditions

• Atrial Fibrillation

Interventions

• DRUG

No Results Yet

NCT04243499 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

293 participants

First-in-Human Study of ICT01 in Patients With Advanced Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-04

Start Date:

2020-03-05

Completion:

2027-10-15

Conditions

• Solid Tumor, Adult
• Hematopoietic/Lymphoid Cancer

Interventions

• BIOLOGICAL

No Results Yet