Donation Advisor Clinical Decision Support Tool Study

Summary

Every year, thousands of Canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available. Patients with non-recoverable illnesses, who are undergoing withdrawal of life sustaining measures, can donate their organs when they die by a process called donation after circulatory determined death (DCD). However, over 30% of all DCD attempts are unsuccessful because patients do not die within the time frame required for healthy organ retrieval and prolonged exposure to low oxygen during the dying process renders organs unsuitable for transplantation. Predicting successful DCD is difficult and leads to uncertainty in the clinical community. To address this issue, the investigators have developed a clinical decision support tool called Donation Advisor (DA) that will assist the healthcare team in identifying successful DCD donors and will provide an improved assessment of the health of their organs. The investigators are ready to implement DA and evaluate its impact in 7 hospitals in Ontario. The investigators believe use of DA will reduce unsuccessful DCD attempts, enhance family experience of donation, optimize system costs, and improve transplant outcomes

Conditions

• Organ Donation

Sponsors & Collaborators

• Gift of Life

  collaborator OTHER

• Canadian Blood Services

  collaborator OTHER

• Health Canada

  collaborator OTHER_GOV

• Canadian National Transplant Research Program

  collaborator OTHER

• The Physicians' Services Incorporated Foundation

  collaborator OTHER

• The Ottawa Hospital

  collaborator OTHER

• Unity Health Toronto

  collaborator OTHER

• Queen's University

  collaborator OTHER

• London Health Sciences Centre

  collaborator OTHER

• Sunnybrook Health Sciences Centre

  collaborator OTHER

• Hamilton Health Sciences Corporation

  collaborator OTHER

• University Health Network, Toronto

  collaborator OTHER

• Ottawa Hospital Research Institute

  lead OTHER

Principal Investigators

• Sonny Dhanani, MD · CHEO-RI

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-01-11

Primary Completion

2023-11-30

Completion

2023-12-31

Countries

• Canada

Study Locations