Clinical Trials Updated in 2026

NCT04521803 | COMPLETED | PHASE2

52 participants

High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-01-10
Completion:: 2026-03-26

Conditions

Tuberculous Pericarditis
HIV Status

Interventions

DRUG

No Results Yet

NCT04501861 | COMPLETED | PHASE3

164 participants

Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-11-05
Completion:: 2023-08-22

Conditions

Cardiac Disease

Interventions

DRUG

Results Available

NCT04484272 | COMPLETED | NA

239 participants

A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-04-29
Completion:: 2026-03-02

Conditions

Sickle Cell Disease

Interventions

BEHAVIORAL

No Results Yet

NCT04464980 | ACTIVE_NOT_RECRUITING | PHASE2

1516 participants

Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-06-08
Completion:: 2026-12-31

Conditions

Opioid Use Disorder (OUD)

Interventions

DRUG
BEHAVIORAL

No Results Yet

NCT04446910 | COMPLETED | NA

50 participants

Using Technology to Reduce Youth Substance Use

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-05-01
Completion:: 2025-04-01

Conditions

Drug Use

Interventions

BEHAVIORAL

Results Available

NCT04442451 | RECRUITING | NA

80 participants

Mechanisms of Fatigability With Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-09-01
Completion:: 2027-07-01

Conditions

Pre-diabetes
Type 2 Diabetes

Interventions

OTHER

No Results Yet

NCT04431024 | RECRUITING

300 participants

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-03-30
Completion:: 2038-06-30

Conditions

Familial Cancer
BRCA1-Associated Protein-1 (BAP1) Mutations
Tumor Predisposition Syndrome (TPDS)
Mesothelioma

No Results Yet

NCT04411147 | ACTIVE_NOT_RECRUITING

583 participants

A Longitudinal Study of COVID-19 Sequelae and Immunity

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-06-17
Completion:: 2027-12-31

Conditions

COVID-19

No Results Yet

NCT04362293 | ACTIVE_NOT_RECRUITING | PHASE2

46 participants

Reduced Intensity Transplantation for Severe Sickle Cell Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-04-30
Completion:: 2026-06-16

Conditions

Sickle Cell Disease

Interventions

DRUG

No Results Yet

NCT04360018 | COMPLETED | PHASE1

20 participants

Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-03-18
Completion:: 2025-04-02

Conditions

Alcohol Consumption

Interventions

OTHER

No Results Yet

NCT04343157 | RECRUITING | PHASE2

90 participants

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-05-01
Completion:: 2028-12-31

Conditions

Brain Metastases, Adult
Neurocognitive Function
Cancer

Interventions

RADIATION

No Results Yet

NCT04315324 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

67 participants

Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-02-08
Completion:: 2025-10-28

Conditions

Recurrent T Acute Lymphoblastic Leukemia
Refractory T Acute Lymphoblastic Leukemia
Refractory T Lymphoblastic Lymphoma
T Lymphoblastic Lymphoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04307277 | RECRUITING | PHASE3

600 participants

Interest of Peri Operative CHemotherapy In Patients With CINSARC High-risk Localized Soft Tissue Sarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-10-09
Completion:: 2032-10-31

Conditions

Soft Tissue Sarcoma

Interventions

DRUG
OTHER

No Results Yet

NCT04305041 | COMPLETED | PHASE1/PHASE2

100 participants

Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-06-26
Completion:: 2025-08-25

Conditions

Melanoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04269239 | COMPLETED | NA

73 participants

Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-04-30
Completion:: 2024-09-30

Conditions

Insomnia
Pain
Osteoarthritis, Knee
Osteoarthritis, Hip

Interventions

BEHAVIORAL

Results Available

NCT04266704 | COMPLETED | NA

50 participants

Building a Multidisciplinary Research Program to Address Hypertension Disparities: Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2023-06-13
Completion:: 2025-04-25

Conditions

Hypertension

Interventions

BEHAVIORAL

Results Available

NCT04266093 | ENROLLING_BY_INVITATION

1000 participants

Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-05-08
Completion:: 2035-10-01

Conditions

Cervical Intraepithelial Neoplasia
Cervical Neoplasms
Oropharyngeal Neoplasms
Squamous Intraepithelial Lesions of the Cervix
Hematologic Malignacies

Interventions

DRUG

No Results Yet

NCT04262843 | ACTIVE_NOT_RECRUITING | PHASE2

33 participants

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-02-07
Completion:: 2027-05-11

Conditions

Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
High Risk Myelodysplastic Syndrome
Myelodysplastic Syndrome

Interventions

DRUG
BIOLOGICAL
PROCEDURE

No Results Yet

NCT04262206 | RECRUITING | PHASE4

20000 participants

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-09-01
Completion:: 2026-12-31

Conditions

Cognitive Impairment, Mild
Dementia
Cardiovascular Diseases

Interventions

DRUG

No Results Yet

NCT04235777 | ACTIVE_NOT_RECRUITING | PHASE1

22 participants

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-07-13
Completion:: 2026-08-31

Conditions

Urothelial Cancer
Bladder Cancer
Genitourinary Cancer
Urogenital Neoplasms
Urogenital Cancer

Interventions

RADIATION
DRUG

No Results Yet

NCT04235764 | RECRUITING

25 participants

En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-09-09
Completion:: 2026-09-30

Conditions

Bladder Cancer

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT04233736 | WITHDRAWN | NA

0 participants

Erector Spinae Plane Blocks (ESP) for Postoperative Pain in Lumbo-sacral Spine Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-07-01
Completion:: 2021-11-01

Conditions

Erector Spinae Plane Block
Lumbar Spine Surgery

Interventions

PROCEDURE

No Results Yet

NCT04209686 | COMPLETED | PHASE2

19 participants

Paclitaxel, Pembrolizumab and Olaparib in Previously Treated Advanced Gastric Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-07-31
Completion:: 2025-11-17

Conditions

Advanced Gastric Adenocarcinoma

Interventions

DRUG

Results Available

NCT04172532 | RECRUITING | PHASE1/PHASE2

92 participants

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-01-11
Completion:: 2027-08-01

Conditions

Locally Advanced Pancreatic Adenocarcinoma
Stage III Pancreatic Cancer AJCC v8

Interventions

PROCEDURE
RADIATION
DRUG
OTHER

No Results Yet

NCT04141709 | ACTIVE_NOT_RECRUITING | NA

66 participants

Local Ablative Radiotherapy for OLIgoprogressive Castration Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-12-01
Completion:: 2027-04-28

Conditions

Oligometastatic Disease
Prostatic Cancer, Castration-Resistant

Interventions

RADIATION

No Results Yet

NCT04125563 | COMPLETED | PHASE2

55 participants

Influence on Cough and Airway Symptoms by Oral Capsaicin

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-06-01
Completion:: 2022-06-28

Conditions

Cough

Interventions

DRUG

No Results Yet

NCT04124341 | RECRUITING | NA

15 participants

PCS in Severe Treatment Resistant Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-09-29
Completion:: 2031-12-31

Conditions

Treatment Resistant Depression

Interventions

DEVICE

No Results Yet

NCT04124029 | RECRUITING

800 participants

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-07-01
Completion:: 2026-12-31

Conditions

Mild Traumatic Brain Injury
Moderate Traumatic Brain Injury
Mild Cognitive Impairment

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT04106349 | ACTIVE_NOT_RECRUITING

150 participants

Observational Real-life Study of Cabozantinib in Monotherapy or in Combination With Nivolumab in Advanced Renal Cell Carcinoma (RCC)

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2020-03-03
Completion:: 2027-03-31

Conditions

Advanced or Metastatic Renal Cell Carcinoma

No Results Yet

NCT04086485 | RECRUITING | PHASE1/PHASE2

56 participants

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2022-10-03
Completion:: 2027-07-01

Conditions

Gastroenteropancreatico Tumors
Neuroendocrine Tumors
Neuroendocrine Neoplasms

Interventions

DRUG
DIAGNOSTIC_TEST

No Results Yet

NCT04077086 | ACTIVE_NOT_RECRUITING | NA

10000 participants

Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2024-11-28
Completion:: 2027-08-30

Conditions

Refractive Errors

Interventions

DEVICE

No Results Yet

NCT04034264 | RECRUITING

6500 participants

Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-07-23
Completion:: 2027-07-01

Conditions

Vector-Borne Diseases
Emerging Pathogens

No Results Yet

NCT04014387 | COMPLETED | PHASE4

40 participants

Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-06-02
Completion:: 2025-06-30

Conditions

Progressive Supranuclear Palsy(PSP)
Insomnia

Interventions

DRUG

No Results Yet

NCT04008706 | COMPLETED | PHASE3

552 participants

Acalabrutinib Safety Study in Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-09-17
Completion:: 2025-11-04

Conditions

Chronic Lymphocytic Leukemia

Interventions

DRUG

Results Available

NCT03998254 | ACTIVE_NOT_RECRUITING | PHASE3

6000 participants

Efficacy, Immunogenicity and Safety of V503 in Chinese Women Aged 20-45 Years (V503-023)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-06-26
Completion:: 2028-03-31

Conditions

Papillomavirus Infections

Interventions

DRUG

No Results Yet

NCT03976843 | ACTIVE_NOT_RECRUITING | PHASE2

175 participants

Prostate Specific Membrane Antigen (PMSA)-Based PET Imaging of High Risk Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-12-04
Completion:: 2027-11-19

Conditions

Prostate Cancer

Interventions

DRUG

No Results Yet

NCT03950076 | COMPLETED | PHASE4

948 participants

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-09-20
Completion:: 2026-07-22

Conditions

Intracranial Hemorrhages
Atrial Fibrillation

Interventions

DRUG
OTHER

No Results Yet

NCT03937830 | ACTIVE_NOT_RECRUITING | PHASE2

27 participants

Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-09-01
Start Date:: 2021-03-10
Completion:: 2026-12-31

Conditions

Hepatocellular Cancer
Hepatocellular Carcinoma
Metastatic Hepatocellular Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03937817 | RECRUITING

300 participants

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-09-25
Completion:: 2029-03-31

Conditions

Alpha and Beta Thalassemia
Sickle Cell Disease
Malaria
Human Physiology

No Results Yet

NCT03937804 | COMPLETED

83 participants

New Approaches for Empowering Studies of Asthma in Populations of African Descent

Study Type:: OBSERVATIONAL
Last Updated:: 2026-09-01
Start Date:: 2019-09-23
Completion:: 2021-07-15

Conditions

Asthma

No Results Yet