Clinical Trials

NCT04673331 | COMPLETED

50 participants

Comparison of Physical Activity, Exercise Capacity, Quality of Life, Cognitive Function and Coronavirus Phobia Levels of Adult Cystic Fibrosis Patients With Healthy Individuals With Telerehabilitation

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2021-01-05

Completion:

2021-08-05

Conditions

• Cystic Fibrosis

Interventions

• OTHER

No Results Yet

NCT04663906 | COMPLETED

148 participants

Oral Isotretinoin and Covid-19 Infection

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2021-01-15

Completion:

2021-09-15

Conditions

• Isotretinoin Adverse Reaction
• Covid19

No Results Yet

NCT04641351 | ACTIVE_NOT_RECRUITING | PHASE4

150 participants

Corticosteroid Meniscectomy Randomized Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-05-27

Completion:

2026-08-01

Conditions

• Osteoarthritis, Knee
• Meniscus Tear
• Meniscus; Degeneration
• Synovitis

Interventions

• DRUG

No Results Yet

NCT04633252 | RECRUITING | PHASE1/PHASE2

86 participants

A Phase I/II Study of PDS01ADC With Docetaxel and Abiraterone in Adults With Metastatic Castration Sensitive and PDS01ADC With Docetaxel in Castration Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-02-23

Completion:

2026-12-31

Conditions

• Cancer Of Prostate
• Prostate Neoplasms

Interventions

• DRUG

No Results Yet

NCT04628481 | TERMINATED | PHASE2

289 participants

A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-01-12

Completion:

2025-03-31

Conditions

• Recent Onset type1 Diabetes

Interventions

• DRUG

Results Available

NCT04609046 | RECRUITING | PHASE1

47 participants

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-05-24

Completion:

2027-04-01

Conditions

• Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04595760 | ACTIVE_NOT_RECRUITING

231 participants

Factors Influencing Fertility or Pregnancy Health

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2020-10-19

Completion:

2030-12-31

Conditions

• Menstrual Cycles
• Conception
• Early Pregnancy Loss
• Pregnancy Outcomes

No Results Yet

NCT04544904 | COMPLETED | NA

356 participants

The Technology, Exercise Programming, and Activity Prescription for Enhanced Mobility (TEAM) Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-06-18

Completion:

2026-06-01

Conditions

• Osteo Arthritis Knee
• Osteoarthritis
• Hip Arthritis

Interventions

• DEVICE

No Results Yet

NCT04538664 | ACTIVE_NOT_RECRUITING | PHASE3

308 participants

A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-10-13

Completion:

2023-05-03

Conditions

• Carcinoma, Non-Small-Cell Lung

Interventions

• DRUG

Results Available

NCT04505371 | COMPLETED | NA

235 participants

Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-06-04

Completion:

2025-03-31

Conditions

• HIV Infections
• Smoking
• Smoking Cessation

Interventions

• BEHAVIORAL

Results Available

NCT04495660 | RECRUITING | NA

80 participants

Restauration of the Auditory and Cognitive Functions in Cochlear Implanted Deaf Children in fNIRS

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-05-29

Completion:

2027-06-03

Conditions

• Deafness

Interventions

• DEVICE
• BEHAVIORAL

No Results Yet

NCT04488536 | ACTIVE_NOT_RECRUITING

10000 participants

Management and Outcomes of Patients Admitted to Coronary Care Units, Depending on Degree of Frailty and Comorbidities

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2020-07-29

Completion:

2021-12-31

Conditions

• Myocardial Infarction
• Frailty

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04455334 | COMPLETED | NA

54 participants

Error-augmented Walking on Gait Performance and Brain Activities in Stroke

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-07-13

Completion:

2022-12-01

Conditions

• Healthy
• Stroke

Interventions

• OTHER

No Results Yet

NCT04452344 | COMPLETED | PHASE3

1815 participants

Opioid Analgesic Reduction Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-01-04

Completion:

2023-07-07

Conditions

• Opioid Use

Interventions

• DRUG

Results Available

NCT04450927 | ENROLLING_BY_INVITATION

10000 participants

Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2020-06-16

Completion:

2040-12-31

Conditions

• Wide Spectrum of Diseases
• Hematologic Diseases

No Results Yet

NCT04449549 | RECRUITING | PHASE2

82 participants

Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-08-24

Completion:

2027-04-02

Conditions

• Neoplasms

Interventions

• DRUG

No Results Yet

NCT04431024 | RECRUITING

300 participants

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2021-03-30

Completion:

2038-06-30

Conditions

• Familial Cancer
• BRCA1-Associated Protein-1 (BAP1) Mutations
• Tumor Predisposition Syndrome (TPDS)
• Mesothelioma

No Results Yet

NCT04430426 | ENROLLING_BY_INVITATION | NA

4 participants

Heterozygous Individuals for AGXT and Kidney Stones

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2027-07-01

Completion:

2031-08-01

Conditions

• Kidney Stone
• Urolithiasis, Calcium Oxalate

Interventions

• OTHER

No Results Yet

NCT04416269 | TERMINATED | PHASE4

85 participants

Oral Anti Diabetic Agents in the Hospital

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-08-07

Completion:

2025-04-11

Conditions

• Diabetes Mellitus

Interventions

• DRUG
• DEVICE

Results Available

NCT04411147 | ACTIVE_NOT_RECRUITING

583 participants

A Longitudinal Study of COVID-19 Sequelae and Immunity

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2020-06-17

Completion:

2027-12-31

Conditions

• COVID-19

No Results Yet

NCT04401449 | COMPLETED

202 participants

Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2020-05-21

Completion:

2023-08-31

Conditions

• Acute and Long Term Effects of COVID-19 on Systemic Inflammation
• Acute and Long Term Effects of COVID-19 on Lung Function
• Acute and Long Term Effects of COVID-19 on Cardiac Function
• Acute and Long Term Effects of COVID-19 on Kidney Function
• Acute and Long Term Effects of COVID-19 on Brain Function

No Results Yet

NCT04388332 | RECRUITING | NA

60 participants

ACDF Using Structural Allograft vs. Tritanium C

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-08-20

Completion:

2026-12-31

Conditions

• Degenerative Disc Disease

Interventions

• PROCEDURE
• DEVICE

No Results Yet

NCT04376489 | COMPLETED | NA

114 participants

Project MARS: Mobile-Assistance for Regulating Smoking

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-08-27

Completion:

2023-10-20

Conditions

• Current Smoker
• Tobacco Smoking

Interventions

• BEHAVIORAL

Results Available

NCT04370093 | COMPLETED | PHASE4

29 participants

Pathogenesis of Uric Acid Nephrolithiasis: Role of Pioglitazone/Weight Loss

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2019-10-17

Completion:

2025-05-28

Conditions

• Nephrolithiasis, Uric Acid

Interventions

• DRUG
• BEHAVIORAL
• OTHER

Results Available

NCT04355195 | RECRUITING

18100 participants

Quality Contract: Prevention of Postoperative Delirium in the Care of Older Patients (QV-POD-2)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2020-04-20

Completion:

2028-06-30

Conditions

• Delirium in Old Age

No Results Yet

NCT04354077 | RECRUITING | NA

3 participants

Deep Brain Stimulation Effects In Patients With Opioid Use Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2022-02-07

Completion:

2029-01-31

Conditions

• Opioid-use Disorder

Interventions

• DEVICE

No Results Yet

NCT04349475 | ACTIVE_NOT_RECRUITING | NA

40 participants

Therapeutic Omegas for Triglyceride Suppression

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-11-29

Completion:

2026-04-30

Conditions

• Pregnancy

Interventions

• DIETARY_SUPPLEMENT

No Results Yet

NCT04308278 | RECRUITING | PHASE4

88 participants

Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-01-22

Completion:

2028-08-22

Conditions

• EBV Infection

Interventions

• DRUG

No Results Yet

NCT04298541 | WITHDRAWN | PHASE2

0 participants

Direct Comparison of Ga-68-DOTATATE and Ga-68-DOTATOC

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2026-08-31

Completion:

2026-08-31

Conditions

• Meningioma

Interventions

• DRUG

No Results Yet

NCT04269213 | COMPLETED | PHASE2

21 participants

CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-07-29

Completion:

2025-05-27

Conditions

• Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
• Acute Myeloid Leukemia With Myelodysplasia-Related Changes
• Secondary Acute Myeloid Leukemia
• Therapy-Related Acute Myeloid Leukemia

Interventions

• DRUG

Results Available

NCT04267861 | ACTIVE_NOT_RECRUITING

232 participants

M7824 Related Adverse Effects in Adults With Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2020-01-28

Completion:

2027-11-01

Conditions

• Neoplasms
• Skin Neoplasms

No Results Yet

NCT04267848 | RECRUITING | PHASE3

1210 participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-06-16

Completion:

2027-01-31

Conditions

• Lung Non-Small Cell Carcinoma
• Lung Non-Small Cell Squamous Carcinoma
• Lung Non-Squamous Non-Small Cell Carcinoma
• Stage II Lung Cancer AJCC v8
• Stage IIIA Lung Cancer AJCC v8
• Stage IIIB Lung Cancer AJCC v8

Interventions

• PROCEDURE
• DRUG
• OTHER
• BIOLOGICAL

No Results Yet

NCT04266093 | ENROLLING_BY_INVITATION

1000 participants

Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2020-05-08

Completion:

2035-10-01

Conditions

• Cervical Intraepithelial Neoplasia
• Cervical Neoplasms
• Oropharyngeal Neoplasms
• Squamous Intraepithelial Lesions of the Cervix
• Hematologic Malignacies

Interventions

• DRUG

No Results Yet

NCT04249843 | TERMINATED | PHASE1

109 participants

Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-02-10

Completion:

2025-08-08

Conditions

• Solid Tumor
• B-Raf Mutation-Related Tumors

Interventions

• DRUG

Results Available

NCT04235777 | ACTIVE_NOT_RECRUITING | PHASE1

22 participants

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-07-13

Completion:

2026-08-31

Conditions

• Urothelial Cancer
• Bladder Cancer
• Genitourinary Cancer
• Urogenital Neoplasms
• Urogenital Cancer

Interventions

• RADIATION
• DRUG

No Results Yet

NCT04201873 | COMPLETED | PHASE1

46 participants

Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-01-08

Completion:

2026-08-13

Conditions

• Recurrent Glioblastoma

Interventions

• BIOLOGICAL
• OTHER
• DRUG

No Results Yet

NCT04190420 | ACTIVE_NOT_RECRUITING

310 participants

The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-31

Start Date:

2018-10-01

Completion:

2030-09-30

Conditions

• Hypertension
• Heart Failure
• Hypertensive Heart Disease
• Diastolic Dysfunction

No Results Yet

NCT04181827 | ACTIVE_NOT_RECRUITING | PHASE3

419 participants

A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-06-12

Completion:

2024-05-01

Conditions

• Multiple Myeloma

Interventions

• DRUG

Results Available

NCT04172532 | RECRUITING | PHASE1/PHASE2

92 participants

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2021-01-11

Completion:

2027-08-01

Conditions

• Locally Advanced Pancreatic Adenocarcinoma
• Stage III Pancreatic Cancer AJCC v8

Interventions

• PROCEDURE
• RADIATION
• DRUG
• OTHER

No Results Yet

NCT04145115 | ACTIVE_NOT_RECRUITING | PHASE2

37 participants

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-31

Start Date:

2020-12-24

Completion:

2026-12-31

Conditions

• Astrocytoma, IDH-Mutant, Grade 4
• Diffuse Glioma
• Glioblastoma, IDH-Wildtype
• Secondary Glioblastoma

Interventions

• BIOLOGICAL
• PROCEDURE

No Results Yet