Clinical Trials Updated in 2026

NCT06788509 | ENROLLING_BY_INVITATION | PHASE1

120 participants

A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-30
Completion:: 2028-01-19

Conditions

Leukemia, Myeloid, Acute
Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, Non-Hodgkin
Myelodysplastic Syndromes
Neoplasms
Solid Tumor, Adult
Prostatic Neoplasms, Castration-Resistant

Interventions

DRUG

No Results Yet

NCT06788444 | RECRUITING | NA

552 participants

Efficacy of Esketamine for Patients With Irritable Bowel Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-02-08
Completion:: 2026-12-31

Conditions

Irritable Bowel Syndrome

Interventions

PROCEDURE
DRUG

No Results Yet

NCT06785012 | COMPLETED | PHASE2

107 participants

A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-26
Completion:: 2026-06-25

Conditions

Depressive Disorder, Major

Interventions

DRUG

No Results Yet

NCT06784726 | RECRUITING | PHASE2

27 participants

Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-09-04
Completion:: 2028-04-10

Conditions

Recurrent Diffuse Large B-Cell Lymphoma
Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Recurrent Grade 3b Follicular Lymphoma
Recurrent High Grade B-Cell Lymphoma
Recurrent Primary Mediastinal Large B-Cell Lymphoma
Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
Refractory Diffuse Large B-Cell Lymphoma
Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Refractory Grade 3b Follicular Lymphoma
Refractory High Grade B-Cell Lymphoma
Refractory Primary Mediastinal Large B-Cell Lymphoma
Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma

Interventions

BIOLOGICAL
PROCEDURE
OTHER

No Results Yet

NCT06780137 | RECRUITING | PHASE1/PHASE2

327 participants

A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-02-27
Completion:: 2029-04-27

Conditions

Small Cell Lung Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT06779188 | RECRUITING | EARLY_PHASE1

30 participants

Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balance Problems

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-05-06
Completion:: 2027-05-01

Conditions

Aging
Balance Deficits

Interventions

DEVICE

No Results Yet

NCT06771713 | ACTIVE_NOT_RECRUITING | NA

50 participants

Brief Pain Reprocessing Therapy in Veterans

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-03-10
Completion:: 2027-01-31

Conditions

Chronic Lower Back Pain (CLBP)

Interventions

BEHAVIORAL

No Results Yet

NCT06762444 | RECRUITING | NA

10 participants

Bump the Lump - Intervention for the Treatment of Globus Pharyngeus

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-08-28
Completion:: 2027-08-31

Conditions

Globus Pharyngeus

Interventions

BEHAVIORAL

No Results Yet

NCT06750094 | RECRUITING | PHASE3

700 participants

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-12
Completion:: 2027-12-15

Conditions

Colorectal Neoplasms

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT06746831 | NOT_YET_RECRUITING | PHASE1

17 participants

Methamphetamine Isomer Pharmacology in Humans

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2026-10-31
Completion:: 2028-10-31

Conditions

Methamphetamine

Interventions

DRUG

No Results Yet

NCT06745921 | ACTIVE_NOT_RECRUITING | PHASE1

30 participants

Safety and Immunogenicity of an Inactivated West Nile Virus Vaccine in Healthy Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-02-24
Completion:: 2026-10-01

Conditions

West Nile Viral Infection

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT06741969 | ACTIVE_NOT_RECRUITING | PHASE3

655 participants

Nipocalimab in Moderate to Severe Sjogren's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-04
Completion:: 2028-01-01

Conditions

Sjogrens Syndrome

Interventions

DRUG

No Results Yet

NCT06736574 | RECRUITING | PHASE3

1800 participants

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-19
Completion:: 2027-09-30

Conditions

Heart Failure
Heart Failure With Reduced Ejection Fraction

Interventions

DRUG

No Results Yet

NCT06735833 | RECRUITING | NA

70 participants

MMA Embolization for Refractory Chronic Migraine

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-04-23
Completion:: 2026-12-25

Conditions

Migraine Disorders

Interventions

DEVICE

No Results Yet

NCT06735534 | RECRUITING | NA

376 participants

Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-06-03
Completion:: 2027-04-30

Conditions

Persistent Atrial Fibrillation

Interventions

DEVICE

No Results Yet

NCT06730633 | COMPLETED | NA

173 participants

Collaborate and Leverage Evidence in African American Rural Network

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-02-22
Completion:: 2026-08-14

Conditions

Cardiovascular Diseases

Interventions

BEHAVIORAL

No Results Yet

NCT06729164 | ACTIVE_NOT_RECRUITING | NA

150 participants

Strategic and Interactive Signing Instruction Experiment

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-04-01
Completion:: 2026-09-30

Conditions

Sign Language Skills
Teacher Practice

Interventions

BEHAVIORAL

No Results Yet

NCT06717789 | COMPLETED | NA

74 participants

Compex SP8.0 - Symptomatic Treatment of Musculoskeletal Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-04-01
Completion:: 2025-12-31

Conditions

Musculoskeletal Conditions
Musculoskeletal Pain

Interventions

DEVICE

No Results Yet

NCT06717347 | RECRUITING | PHASE3

1046 participants

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-01-27
Completion:: 2029-07-02

Conditions

Diffuse Large B-Cell Lymphoma

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT06714097 | RECRUITING | NA

20 participants

Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2026-10-31
Completion:: 2027-10-31

Conditions

Stroke
Moyamoya Disease
Cerebral Amyloid Angiopathy

Interventions

DEVICE
OTHER

No Results Yet

NCT06713382 | RECRUITING | PHASE2

96 participants

Evaluating the Efficacy and Safety of Saline Irrigation as an Add-On Therapy for Retained Pleural Infections [LYTICS +]

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-04-10
Completion:: 2026-11-20

Conditions

Pleural Effusion Associated With Pulmonary Infection
Pleural Effusion Disorder
Pleural Effusions

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT06712836 | COMPLETED | PHASE2

239 participants

A Phase 2b Study to Examine the Safety and Efficacy of Once-Weekly MET097 in Adults With Obesity or Overweight

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-10-09
Completion:: 2025-07-03

Conditions

Obesity
Overweight or Obesity

Interventions

DRUG

Results Available

NCT06706674 | RECRUITING | PHASE3

160 participants

Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-06
Completion:: 2027-06-21

Conditions

Irritability Associated With Autism Spectrum Disorder

Interventions

DRUG

No Results Yet

NCT06704672 | RECRUITING | NA

270 participants

Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes Mellitus

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-04-14
Completion:: 2026-11-15

Conditions

Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus

Interventions

DEVICE

No Results Yet

NCT06700447 | ACTIVE_NOT_RECRUITING | NA

2163 participants

Protecting Against HIV Vaccine Misinformation With Adolescent Girls and Young Women in South Africa

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-07-24
Completion:: 2025-10-16

Conditions

Misinformation
HIV Vaccine

Interventions

BEHAVIORAL

Results Available

NCT06693271 | RECRUITING | NA

240 participants

Investigating the Combined Effects of Protein, Blueberries, and Exercise on Cardiovascular Health and Frailty in Older Nova Scotians

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-12-15
Completion:: 2028-06-30

Conditions

Cardiovascular Disease
Frailty

Interventions

DIETARY_SUPPLEMENT
BEHAVIORAL

No Results Yet

NCT06690827 | RECRUITING | PHASE1

30 participants

Clinical Trial of CD123-targeted CAR-NK Therapy for Relapse/Refractory AML or BPDCN

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-12
Completion:: 2027-06-30

Conditions

AML (Acute Myeloid Leukemia)
BPDCN (Blastic Plasmacytoid Dendritic Cell Neoplasm)

Interventions

DRUG

No Results Yet

NCT06690398 | RECRUITING | PHASE3

160 participants

Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder in Pediatric Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-11-22
Completion:: 2027-06-21

Conditions

Irritability Associated With Autism Spectrum Disorder

Interventions

DRUG

No Results Yet

NCT06687772 | RECRUITING | PHASE2

36 participants

CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based Autologous Stem Cell Transplant

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-01-16
Completion:: 2028-07-31

Conditions

Diffuse Large B Cell Lymphoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT06684483 | RECRUITING

72 participants

The Impact of Heavy Alcohol Use on Saliva and Oral Health

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-01-09
Completion:: 2026-12-01

Conditions

Alcohol Use Disorder
Alcohol Dependence

No Results Yet

NCT06683755 | RECRUITING | PHASE1/PHASE2

30 participants

Phase I/IIa Dose Finding Study of Triplet Regimen of Relatlimab Ipilimumab and NIvolumab in First Line Therapy of Metastatic Melanoma (TRINITY)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-31
Completion:: 2030-08-16

Conditions

Melanoma

Interventions

DRUG

No Results Yet

NCT06682780 | RECRUITING | PHASE1/PHASE2

320 participants

A Phase I/II Study of LM-2417 in Subjects With Advanced Solid Tumours

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-09-17
Completion:: 2028-12-25

Conditions

Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT06680830 | RECRUITING | PHASE2

150 participants

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-01-17
Completion:: 2027-12-31

Conditions

Parkinson Disease
Parkinson
Idiopathic Parkinson Disease
Early Parkinson Disease (Early PD)
Parkinson Disease, Idiopathic

Interventions

DRUG
OTHER

No Results Yet

NCT06667908 | RECRUITING | PHASE2

130 participants

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-06
Completion:: 2028-12-31

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

DRUG
BIOLOGICAL
RADIATION

No Results Yet

NCT06667700 | RECRUITING | PHASE3

3082 participants

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-02
Completion:: 2031-01-26

Conditions

Coronavirus Disease (COVID-19)

Interventions

DRUG

No Results Yet

NCT06667076 | RECRUITING | PHASE2

480 participants

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-16
Completion:: 2029-05-23

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

DRUG

No Results Yet

NCT06666985 | RECRUITING | PHASE4

700 participants

Intrathecal Morphine for Postoperative Analgesia in Major Laparoscopic Abdominal Surgery, a IMPACT-Scope Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-12-16
Completion:: 2026-09-30

Conditions

Patients Undergoing Major Laparoscopic Abdominal Surgery

Interventions

DRUG

No Results Yet

NCT06664788 | RECRUITING | NA

108 participants

A Study of ETHIZIA Versus SURGICEL Original in Controlling Soft Tissue Bleeding During Open Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2025-04-16
Completion:: 2026-09-28

Conditions

Hemostasis
Hemostatic Techniques

Interventions

DEVICE

No Results Yet

NCT06663332 | RECRUITING | PHASE3

196 participants

A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-10-29
Completion:: 2031-12-12

Conditions

Crohns Disease
Colitis, Ulcerative
Arthritis, Psoriatic
Arthritis, Juvenile

Interventions

DRUG

No Results Yet

NCT06663319 | RECRUITING | PHASE1

260 participants

A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-28
Start Date:: 2024-10-15
Completion:: 2028-02-25

Conditions

Colorectal Neoplasms
Gastrointestinal Neoplasms

Interventions

DRUG

No Results Yet