Clinical Trials

NCT06789913 | RECRUITING | PHASE2
277 participants

A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-12
Start Date:
2025-06-13
Completion:
2031-07-31
Conditions
  • PIK3CA-Related Overgrowth Spectrum (PROS)
  • Lymphatic Malformations
  • Vascular Malformations
  • PIK3CA Mutation
  • CLOVES Syndrome
  • Klippel Trenaunay Syndrome
  • Megalencephaly-capillary Malformation Polymicrogyria Syndrome (MCAP)
  • Vascular Anomalies
Interventions
  • DRUG
No Results Yet
NCT06725550 | RECRUITING | NA
120 participants

Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-12
Start Date:
2026-07-01
Completion:
2030-06-28
Conditions
  • Sickle Cell Disease
  • Pain
  • Acupuncture
  • Quantitative Sensory Testing
  • Magnetic Resonance Imaging
  • Circulating Biomarkers
  • Electroencephalography
  • Functional Near-infrared Spectroscopy
Interventions
  • DEVICE
No Results Yet
NCT06717308 | RECRUITING | NA
300 participants

Evaluation of a Switchable Acrylic Adhesive Drape for Safer Removal in Negative Pressure Wound Therapy Applications.

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-12
Start Date:
2025-02-10
Completion:
2027-02-28
Conditions
  • Frequency and Type of Medical Adhesive-Related Skin Injury
  • NPWT Drape Seal Effectiveness Rate (or Leak Incidence Rate)
  • Clinician Acceptability of New NPWT Drape
  • Patient Drop-out Rate From Prescribed NPWT Treatment
  • Pain Assessment During Medical Adhesive Drape Removal
Interventions
  • DEVICE
No Results Yet
NCT06691269 | RECRUITING | NA
200 participants

Photobiomodulation and Tooth Analgesia

Study Type:
INTERVENTIONAL
Last Updated:
2026-08-12
Start Date:
2025-07-07
Completion:
2027-06-30
Conditions
  • Dental Anaesthesia
  • Dental Pain
  • Dental Analgesia
Interventions
  • DEVICE
  • DRUG
No Results Yet
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