Clinical Trials

NCT05600933 | ENROLLING_BY_INVITATION

1200 participants

Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor Microenvironment

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2023-05-15

Completion:

2033-06-15

Conditions

• Solid Tumors
• Hematologic Malignancy
• Gastrointestinal Cancer
• Liver Cancer
• Pancreatic Cancer
• Melanoma
• Pre-Malignancy
• Lung Cancer

No Results Yet

NCT05591768 | COMPLETED | NA

90 participants

Monopolar Versus Biopolar Radiofrequency in OA Knee Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-11-14

Completion:

2024-02-01

Conditions

• Osteoarthritis, Knee

Interventions

• PROCEDURE

No Results Yet

NCT05581004 | ACTIVE_NOT_RECRUITING | PHASE1

165 participants

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-10-20

Completion:

2028-07-31

Conditions

• Locally Advanced or Metastatic Solid Tumors
• NSCLC
• HNSCC
• Melanoma
• TNBC
• Esophageal Cancer
• Gastric Cancer
• Cervical Cancer
• Colorectal Cancer
• Urothelial Carcinoma
• Clear Cell RCC
• HCC

Interventions

• DRUG

No Results Yet

NCT05565118 | RECRUITING | PHASE1

10 participants

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2024-04-09

Completion:

2026-12-31

Conditions

• High Grade Glioma
• Glioblastoma

Interventions

• PROCEDURE

No Results Yet

NCT05553912 | COMPLETED | NA

154 participants

QBSafe: a Randomized Trial of a Novel Intervention to Improve Care for People Living With Type 2 Diabetes.

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-11-02

Completion:

2025-02-24

Conditions

• Type2Diabetes
• Diabetes

Interventions

• BEHAVIORAL

Results Available

NCT05551754 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

10 participants

Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-10-20

Completion:

2026-12-31

Conditions

• Alcohol Drinking

Interventions

• DIETARY_SUPPLEMENT
• OTHER

No Results Yet

NCT05546866 | ACTIVE_NOT_RECRUITING | PHASE2

51 participants

Study to Assess the Efficacy and Safety of Adjuvant Osimertinib in NSCLC With Uncommon EGFRm

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-02-09

Completion:

2029-06-30

Conditions

• Non-small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT05543616 | COMPLETED | PHASE3

4338 participants

A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-09-23

Completion:

2026-07-10

Conditions

• SARS-CoV-2 Virus
• Severe Acute Respiratory Syndrome Coronavirus 2
• COVID-19

Interventions

• BIOLOGICAL

No Results Yet

NCT05535244 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

90 participants

A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-10-17

Completion:

2027-02-26

Conditions

• Multiple Myeloma

Interventions

• DRUG

No Results Yet

NCT05528172 | COMPLETED | PHASE3

330 participants

A Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract Surgery

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-08-04

Completion:

2023-06-22

Conditions

• Corneal Edema After Cataract Surgery

Interventions

• DRUG

Results Available

NCT05524012 | ACTIVE_NOT_RECRUITING

40 participants

Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2022-11-30

Completion:

2026-01-31

Conditions

• Locally Advanced Rectal Carcinoma
• Neoadjuvant Treatment
• Radiotherapy
• Adaptive Treatment

Interventions

• DIAGNOSTIC_TEST
• DEVICE

No Results Yet

NCT05515874 | WITHDRAWN | PHASE4

0 participants

Predicting Stroke Risk in ICAD With Novel MRI

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2020-09-01

Completion:

2025-06-30

Conditions

• Intracranial Atherosclerosis

Interventions

• DRUG

No Results Yet

NCT05511324 | ACTIVE_NOT_RECRUITING | NA

124 participants

Simulation-Based Caregiving Skills Training for Family Members of High Grade Glioma Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-10-21

Completion:

2026-08-31

Conditions

• Glioma

Interventions

• BEHAVIORAL

No Results Yet

NCT05483868 | ACTIVE_NOT_RECRUITING | PHASE1

55 participants

A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-09-26

Completion:

2027-03-31

Conditions

• Non-muscle-invasive Bladder Cancer
• NMIBC
• Non-Muscle Invasive Bladder Carcinoma
• Non-Muscle Invasive Bladder Neoplasms
• Non-Muscle Invasive Bladder Urothelial Carcinoma
• Urothelial Carcinoma Bladder

Interventions

• DRUG
• COMBINATION_PRODUCT

No Results Yet

NCT05445830 | COMPLETED | NA

62 participants

Exercise Intolerance in Post-COVID Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-09-01

Completion:

2023-09-15

Conditions

• Post-COVID Syndrome

Interventions

• PROCEDURE

No Results Yet

NCT05436756 | COMPLETED | NA

198 participants

Chronic Post-leptospirosis Manifestations in Reunion

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-07-25

Completion:

2026-04-28

Conditions

• Leptospirosis

Interventions

• OTHER

No Results Yet

NCT05401110 | RECRUITING | PHASE1

60 participants

Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-09-15

Completion:

2028-01-31

Conditions

• Non Small Cell Lung Cancer
• Lung Cancer

Interventions

• DRUG

No Results Yet

NCT05400382 | RECRUITING | NA

75 participants

Maternal Mindfulness: Depression and Postpartum Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2025-12-01

Completion:

2028-03-31

Conditions

• Depression, Unipolar
• Pain, Postoperative

Interventions

• BEHAVIORAL

No Results Yet

NCT05398185 | ACTIVE_NOT_RECRUITING | NA

241 participants

WiseApp for Spanish Speakers Living With HIV

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-03-01

Completion:

2026-11-01

Conditions

• HIV Infections
• Acquired Immune Deficiency Syndrome
• Sexually Transmitted Diseases, Viral

Interventions

• DEVICE

No Results Yet

NCT05397691 | ACTIVE_NOT_RECRUITING | NA

80 participants

Substance Use Prevention for Youth With Parents in Recovery

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2024-08-29

Completion:

2026-07-31

Conditions

• Substance Use Disorders

Interventions

• OTHER

No Results Yet

NCT05390567 | RECRUITING

800 participants

Project CONTINUITY: Promoting Evidence-Based Cancer Screening Among Underserved Women

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2024-06-07

Completion:

2027-05-01

Conditions

• Cervical Cancer Screening Methods

Interventions

• BEHAVIORAL

No Results Yet

NCT05386108 | RECRUITING | PHASE1/PHASE2

73 participants

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-08-31

Completion:

2026-12-31

Conditions

• Breast Neoplasms
• Brain Neoplasms
• Neoplasms by Site
• Neoplasms
• Breast Diseases
• Central Nervous System Neoplasms
• Brain Diseases
• Central Nervous System Diseases

Interventions

• DRUG

No Results Yet

NCT05375812 | RECRUITING

85 participants

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2023-04-16

Completion:

2030-12-31

Conditions

• Gulf War Illness

No Results Yet

NCT05374824 | RECRUITING

4680 participants

Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2022-04-01

Completion:

2026-12-31

Conditions

• Lennox Gastaut Syndrome

No Results Yet

NCT05372614 | RECRUITING | PHASE1

58 participants

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-10-05

Completion:

2028-07-17

Conditions

• Metastatic Malignant Solid Neoplasm
• Metastatic Pancreatic Adenocarcinoma
• Stage III Pancreatic Cancer AJCC v8
• Stage IV Pancreatic Cancer AJCC v8
• Unresectable Malignant Solid Neoplasm
• Unresectable Pancreatic Adenocarcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT05368493 | ENROLLING_BY_INVITATION | NA

182 participants

Air Pollution and Development in the Boricua Youth Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-01-23

Completion:

2028-06-01

Conditions

• Pollution; Exposure
• Neurodevelopmental Disorders

Interventions

• OTHER

No Results Yet

NCT05353192 | COMPLETED | PHASE4

39 participants

A Study to Evaluate the Efficacy and Safety of Recombinant Human Growth Hormone in Children With Achondroplasia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-08-20

Completion:

2025-08-25

Conditions

• Achondroplasia

Interventions

• DRUG

No Results Yet

NCT05325931 | COMPLETED | NA

30 participants

1-Week Dispensing Evaluation of Kalifilcon A Daily Disposable Multifocal Compared to Ultra for Presbyopia

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-02-25

Completion:

2022-03-28

Conditions

• Presbyopia

Interventions

• DEVICE

Results Available

NCT05313529 | COMPLETED | NA

396 participants

LIGHT-MCI Trial: GLP-1 Agonist, SGLT2 Inhibitor, and DPP-4 Inhibitor for MCI Remission in Type 2 Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-10-08

Completion:

2025-12-31

Conditions

• Type 2 Diabetes Mellitus
• Mild Cognitive Impairment

Interventions

• DRUG

No Results Yet

NCT05304416 | ACTIVE_NOT_RECRUITING

347 participants

Clinical Markers of Dysphagia in Cardiac Surgical Patients

Study Type:

OBSERVATIONAL

Last Updated:

2026-08-06

Start Date:

2022-06-07

Completion:

2026-07-31

Conditions

• Cardiovascular Diseases
• Dysphagia

Interventions

• DIAGNOSTIC_TEST
• OTHER

No Results Yet

NCT05276739 | COMPLETED | NA

47 participants

Role of Photic and Non-photic Time Cues in Resetting Circadian Rhythms

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-07-29

Completion:

2026-07-31

Conditions

• Light Exposure
• Meal Timing

Interventions

• BEHAVIORAL

No Results Yet

NCT05261399 | ACTIVE_NOT_RECRUITING | PHASE3

341 participants

Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-08-03

Completion:

2026-07-06

Conditions

• Carcinoma
• Non-Small-Cell Lung

Interventions

• DRUG

No Results Yet

NCT05232916 | RECRUITING | PHASE3

2250 participants

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-12-16

Completion:

2031-12-31

Conditions

• Breast Cancer

Interventions

• BIOLOGICAL

No Results Yet

NCT05226507 | TERMINATED | PHASE1

45 participants

A Phase 1 Clinical Study of NXP800 in Subjects With Advanced Cancers and Expansion in Subjects With Ovarian Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-12-31

Completion:

2025-01-01

Conditions

• Advanced Solid Tumor
• Ovarian Cancer
• Ovarian Clear Cell Carcinoma
• Ovarian Clear Cell Tumor
• Ovarian Clear Cell Adenocarcinoma
• Ovarian Endometrioid Adenocarcinoma
• Ovarian Endometrioid Tumor
• ARID1A Gene Mutation

Interventions

• DRUG

No Results Yet

NCT05210374 | RECRUITING | PHASE1

24 participants

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2023-03-09

Completion:

2026-09-01

Conditions

• Relapsed Sarcomas

Interventions

• DRUG

No Results Yet

NCT05207059 | ACTIVE_NOT_RECRUITING | NA

500 participants

Healthy Early Life Moments in Singapore

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-03-18

Completion:

2027-12-31

Conditions

• Metabolic Disease
• Mental Health Wellness 1
• Lifestyle Risk Reduction
• Maternal Obesity

Interventions

• BEHAVIORAL

No Results Yet

NCT05176808 | COMPLETED | NA

117 participants

Telehealth Parent-Implemented Intervention for Young Children With Autism Spectrum Disorder (ASD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-02-07

Completion:

2026-04-10

Conditions

• Autism Spectrum Disorder
• Autistic Disorder
• Active Autistic Disorder
• Autism
• Asperger Syndrome
• PDD-NOS
• Social Communication Delay
• Mixed Expressive Receptive Language Disorder
• Other Symbolic Dysfunctions

Interventions

• BEHAVIORAL

No Results Yet

NCT05172934 | COMPLETED | PHASE2

20 participants

Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2022-04-11

Completion:

2023-09-12

Conditions

• Ischemic Stroke

Interventions

• DRUG

Results Available

NCT05107115 | COMPLETED | PHASE2

160 participants

Rilzabrutinib for the Treatment of Chronic Spontaneous Urticaria in Patients Who Remain Symptomatic Despite the Use of H1 Antihistamine

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-11-24

Completion:

2023-07-19

Conditions

• Chronic Spontaneous Urticaria

Interventions

• DRUG

Results Available

NCT05093634 | COMPLETED | PHASE3

296 participants

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

Study Type:

INTERVENTIONAL

Last Updated:

2026-08-06

Start Date:

2021-12-10

Completion:

2025-12-22

Conditions

• Obesity
• Genetic Obesity

Interventions

• DRUG

No Results Yet