Clinical Trials

NCT06982521 | RECRUITING | PHASE3

540 participants

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-08-26
Completion:: 2028-04-30

Conditions

PIK3CA Mutation
HER2- Negative Breast Cancer
Hormone Receptor Positive Tumor
Breast Cancer
Metastatic Breast Cancer
Advanced Breast Cancer

Interventions

DRUG

No Results Yet

NCT06982131 | RECRUITING | PHASE1

40 participants

A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-06-04
Completion:: 2026-12-04

Conditions

Overweight
Obesity

Interventions

DRUG

No Results Yet

NCT06979362 | RECRUITING | PHASE2

200 participants

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-06-27
Completion:: 2027-11-16

Conditions

Heart Failure

Interventions

DRUG

No Results Yet

NCT06957509 | RECRUITING

100 participants

Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-04-04
Completion:: 2026-12-31

Conditions

Early Childhood Caries (ECC)

No Results Yet

NCT06952504 | RECRUITING | PHASE3

1123 participants

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-05-22
Completion:: 2032-05-24

Conditions

Endometrial Cancer

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT06940791 | RECRUITING | PHASE2

92 participants

Tirabrutinib Maintenance Versus Placebo in Patients With Primary CNS Lymphoma in Complete Remission (JCOG2104)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2023-10-06
Completion:: 2030-02-28

Conditions

Primary Central Nervous System Lymphoma

Interventions

DRUG

No Results Yet

NCT06937944 | RECRUITING | PHASE3

669 participants

Efficacy and Safety of Recombinant Botulinum Toxin Type A (Eveotox) for Injection to Treat Moderate to Severe Glabellar Lines

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-04-30
Completion:: 2026-02-09

Conditions

Moderate to Severe Glabellar Lines

Interventions

BIOLOGICAL

No Results Yet

NCT06935357 | RECRUITING | PHASE3

454 participants

A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-05-08
Completion:: 2027-05-31

Conditions

Immunoglobulin A Nephropathy (IgAN)

Interventions

DRUG

No Results Yet

NCT06931340 | RECRUITING | PHASE3

1260 participants

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-12-01
Completion:: 2031-11-11

Conditions

Castration-Sensitive Prostate Carcinoma
Metastatic Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8

Interventions

DRUG
PROCEDURE
OTHER

No Results Yet

NCT06910657 | RECRUITING | PHASE1

78 participants

IDOV-Immune for Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-08-25
Completion:: 2027-01-31

Conditions

Colorectal Cancer
Pancreatic Cancer
Melanoma
Ovarian Cancer
Gastric Cancer
Esophageal Cancer
Hepatocellular Carcinoma
Renal Cell Carcinoma
Breast Cancer
Sarcoma
Bladder Cancer
Lung Cancer
Prostate Cancer
Cervical Cancers
Head and Neck Cancers
Adrenal Gland Tumors

Interventions

BIOLOGICAL

No Results Yet

NCT06903702 | WITHDRAWN | PHASE2

0 participants

A Study of Azacitidine and Venetoclax Versus a Stem Cell Transplant in People 65 Years and Older With Acute Myeloid Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2026-08-04
Completion:: 2027-06-30

Conditions

Acute Myeloid Leukemia

Interventions

DRUG
PROCEDURE

No Results Yet

NCT06902558 | RECRUITING | PHASE2

240 participants

ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-06-09
Completion:: 2029-08-31

Conditions

Autosomal Dominant Polycystic Kidney Disease

Interventions

DRUG

No Results Yet

NCT06895538 | RECRUITING | PHASE2/PHASE3

24 participants

Comparison of ATLG and ATG for Immune Reconstitution After Allo-HSCT for Hematologic Malignancy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-05-03
Completion:: 2027-02-28

Conditions

Leukemia
MDS
Lymphoma

Interventions

DRUG

No Results Yet

NCT06892496 | RECRUITING | NA

56 participants

Patient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-03-07
Completion:: 2027-01-31

Conditions

Mucosal Erosion
Gingival Recession

Interventions

OTHER

No Results Yet

NCT06876714 | RECRUITING | PHASE3

1524 participants

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-09-17
Completion:: 2028-03-13

Conditions

Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Early Stage HER2+ Breast Cancer

Interventions

BIOLOGICAL
PROCEDURE
OTHER

No Results Yet

NCT06876246 | RECRUITING | NA

1270 participants

SBIR/ STTR Family Check-up Online

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-01-20
Completion:: 2026-08-31

Conditions

Mental Health
Parenting Stress
Academic Achievement
Parenting Skills
Behavior Problems

Interventions

BEHAVIORAL

No Results Yet

NCT06872125 | RECRUITING | PHASE3

170 participants

A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-06-04
Completion:: 2027-03-31

Conditions

Dravet Syndrome

Interventions

DRUG
OTHER

No Results Yet

NCT06869967 | RECRUITING | NA

56 participants

Evaluation of Postoperative Pain Control in Ear Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-10-20
Completion:: 2026-11-25

Conditions

Post Operative Pain
Analgesia

Interventions

PROCEDURE

No Results Yet

NCT06862128 | ACTIVE_NOT_RECRUITING | NA

70 participants

OGTT at Home Using CGM vs at the Clinic

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-06-11
Completion:: 2026-05-21

Conditions

Pre-diabetes
Diabetes

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06862115 | RECRUITING | PHASE3

156 participants

The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-03-01
Completion:: 2026-11-01

Conditions

Myocardium; Injury
Perioperative/Postoperative Complications
Angiotensin-Converting-Enzyme Inhibitor

Interventions

DRUG

No Results Yet

NCT06861608 | RECRUITING | NA

160 participants

A Single-session Intervention Adaptation of the Habit Framework for the Prevention of Eating Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-01-15
Completion:: 2026-12-31

Conditions

Eating Disorder Not Otherwise Specified

Interventions

BEHAVIORAL

No Results Yet

NCT06854718 | RECRUITING | NA

60 participants

Pain With Dementia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-08-13
Completion:: 2026-12-01

Conditions

Pain
Dementia, Mild
Dementia, Moderate

Interventions

BEHAVIORAL

No Results Yet

NCT06853470 | COMPLETED | NA

222 participants

Prospective Evaluation for Receiving SynFlow 3.0 Interventional Circulatory Support in High-risk PCI: A Randomized Controlled Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2024-09-10
Completion:: 2025-05-27

Conditions

High Risk PCI
Coronary Arterial Disease (CAD)

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT06851754 | RECRUITING | PHASE3

185 participants

Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-07-17
Completion:: 2031-12-01

Conditions

Premature Ovarian Insufficiency

Interventions

DRUG

No Results Yet

NCT06848023 | ENROLLING_BY_INVITATION

74 participants

Reverse Shoulder Arthroplasty vs Rotator Cuff Repair for 60+

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-06-10
Completion:: 2027-12-31

Conditions

Shoulder Injuries
Shoulder Pain

Interventions

PROCEDURE

No Results Yet

NCT06828328 | RECRUITING | EARLY_PHASE1

10 participants

A Study of GC203 TIL in PDCA (RJ)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-02-10
Completion:: 2028-01-31

Conditions

Pancreatic Cancer
Pancratic Ductal Adenocarcinoma
Treatment Side Effects
Tumor Infiltrating Lymphocytes

Interventions

BIOLOGICAL

No Results Yet

NCT06822426 | RECRUITING | PHASE3

200 participants

Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-05-14
Completion:: 2028-01-31

Conditions

Central Line Associated Blood Stream Infections (CLABSI)

Interventions

DRUG

No Results Yet

NCT06820658 | RECRUITING

80 participants

A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-02-26
Completion:: 2028-09-01

Conditions

Healthy
Insulin Resistance

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06816108 | ACTIVE_NOT_RECRUITING | PHASE1

35 participants

A Study of ONO-7428 in Participants With Unresectable Advanced or Recurrent Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-04-21
Completion:: 2029-07-31

Conditions

Solid Tumor
NSCLC

Interventions

DRUG

No Results Yet

NCT06809140 | RECRUITING | PHASE2

75 participants

Enfortumab Vedotin Plus Pembrolizumab With Selective Bladder Sparing for Treatment of Muscle-invasive Bladder Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-04-07
Completion:: 2027-11-30

Conditions

Muscle Invasive Bladder Urothelial Carcinoma

Interventions

DRUG

No Results Yet

NCT06805630 | ACTIVE_NOT_RECRUITING | NA

50 participants

Urine Methylation Markers in UTUC

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-05-07
Completion:: 2026-12-30

Conditions

Upper Tract Urothelial Cancer

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06800209 | RECRUITING | PHASE2

110 participants

Pain Reprocessing Therapy in Post-Operative Knee Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-08-13
Completion:: 2027-09-30

Conditions

Pain, Chronic
Knee Pain Chronic

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT06800196 | RECRUITING | PHASE1

151 participants

A Study of KNT-0916 in Treatment of Unresectable or Metastatic Solid Tumors With FGFR2 Alterations

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-04-10
Completion:: 2027-09-30

Conditions

Solid Tumors With FGFR2 Alterations, Adult

Interventions

DRUG

No Results Yet

NCT06796504 | RECRUITING | NA

60 participants

The SetPoint System as a Pro-Remyelination Therapy for Relapsing-Remitting Multiple Sclerosis: A Pilot Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2026-04-17
Completion:: 2027-12-31

Conditions

Relapsing Remitting Multiple Sclerosis

Interventions

PROCEDURE
DRUG
DEVICE

No Results Yet

NCT06790693 | RECRUITING | PHASE3

450 participants

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-04-09
Completion:: 2032-05-30

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT06788756 | RECRUITING | PHASE2/PHASE3

312 participants

L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-03-12
Completion:: 2029-08-31

Conditions

Acute Myeloid Leukaemia (AML)

Interventions

DRUG

No Results Yet

NCT06786039 | RECRUITING

80 participants

Clinical Impact of Non-invasive Neurally Adjusted Ventilatory Assist in Very Preterm Infants

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-01-20
Completion:: 2029-12-20

Conditions

Preterm Infant

Interventions

PROCEDURE

No Results Yet

NCT06775132 | ACTIVE_NOT_RECRUITING

240 participants

Associations Between Dietary Intake and Cardiometabolic and Gut Microbiota Outcomes

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-02-03
Completion:: 2026-06-30

Conditions

Cardiometabolic Risk Factors
Skin Condition
Cognitive Ability, General
Sleep Quality
Gut-Microbiota

No Results Yet

NCT06771037 | TERMINATED | NA

12 participants

Use of tAN® in Alcohol Withdrawal Management

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-04-21
Completion:: 2025-10-07

Conditions

Alcohol Withdrawal

Interventions

DEVICE

No Results Yet

NCT06770660 | RECRUITING | NA

122 participants

Effect of Tele-exercise on Cardiorespiratory Fitness in Paediatrics

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-05
Start Date:: 2025-05-02
Completion:: 2027-06-30

Conditions

Cardiorespiratory Fitness
Insulin Resistance

Interventions

BEHAVIORAL

No Results Yet