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Pain Reprocessing Therapy in Post-Operative Knee Pain

NCT06800209 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 110

Last updated 2026-03-31

No results posted yet for this study

Summary

The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain.

The main questions the study aims to answer are:

1. Does PRT help lower pain in people who have chronic knee pain after knee surgery?
2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, and sleep?
3. How does PRT impact the brain?

Participants will:

1. Be randomly assigned to receive either PRT or usual care.
2. Complete questionnaires about their pain and health.
3. If in the PRT group, have eight weekly therapy sessions over video calls with a therapist.
4. If interested, may also take part in an optional EEG test to measure brain activity related to pain.

Conditions

  • Pain, Chronic
  • Knee Pain Chronic

Interventions

BEHAVIORAL

Pain reprocessing therapy (PRT)

A promising new psychotherapy for chronic pain.

OTHER

Usual care

Participants will be asked to continue to do whatever they are currently doing to manage their pain.

Sponsors & Collaborators

  • Hospital for Special Surgery, New York

    collaborator OTHER

  • Weill Medical College of Cornell University

    collaborator OTHER

  • University of Colorado, Denver

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-13
Primary Completion
2027-09-30
Completion
2028-09-29

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06800209 on ClinicalTrials.gov