Clinical Trials

NCT04617925 | COMPLETED | PHASE2

35 participants

A Study of Belantamab Mafodotin in Patients With Relapsed or Refractory AL Amyloidosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-02-26

Completion:

2025-07-17

Conditions

• AL Amyloidosis

Interventions

• DRUG

No Results Yet

NCT04616534 | ACTIVE_NOT_RECRUITING | PHASE1

14 participants

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-06-01

Completion:

2025-04-01

Conditions

• Advanced Fallopian Tube Carcinoma
• Advanced Malignant Solid Neoplasm
• Advanced Ovarian Carcinoma
• Advanced Pancreatic Adenocarcinoma
• Advanced Primary Peritoneal Carcinoma
• Fallopian Tube High Grade Serous Adenocarcinoma
• Metastatic Pancreatic Adenocarcinoma
• Ovarian High Grade Serous Adenocarcinoma
• Platinum-Resistant Fallopian Tube Carcinoma
• Platinum-Resistant Ovarian Carcinoma
• Platinum-Resistant Primary Peritoneal Carcinoma
• Primary Peritoneal High Grade Serous Adenocarcinoma
• Stage II Pancreatic Cancer AJCC v8
• Stage III Fallopian Tube Cancer AJCC v8
• Stage III Ovarian Cancer AJCC v8
• Stage III Pancreatic Cancer AJCC v8
• Stage III Primary Peritoneal Cancer AJCC v8
• Stage IV Fallopian Tube Cancer AJCC v8
• Stage IV Ovarian Cancer AJCC v8
• Stage IV Pancreatic Cancer AJCC v8
• Stage IV Primary Peritoneal Cancer AJCC v8
• Unresectable Pancreatic Adenocarcinoma

Interventions

• PROCEDURE
• DRUG

Results Available

NCT04595747 | ACTIVE_NOT_RECRUITING | PHASE2

48 participants

Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-05-03

Completion:

2027-07-31

Conditions

• Locally Advanced Gastrointestinal Stromal Tumor
• Locally Advanced Sarcoma
• Metastatic Gastrointestinal Stromal Tumor
• Metastatic Sarcoma
• Stage III Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8
• Stage III Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8
• Stage IV Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8
• Stage IV Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8

Interventions

• PROCEDURE
• DRUG

No Results Yet

NCT04557098 | ACTIVE_NOT_RECRUITING | PHASE2

194 participants

A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-09-17

Completion:

2021-11-09

Conditions

• Hematological Malignancies

Interventions

• DRUG

No Results Yet

NCT04554914 | ACTIVE_NOT_RECRUITING | PHASE2

190 participants

A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-07-14

Completion:

2027-06-30

Conditions

• Epstein-Barr Virus (EBV)-Associated Diseases
• EBV+ Lymphoproliferative Disease With Primary Immunodeficiency (EBV+ PID LPD)
• EBV+ Lymphoproliferative Disease With Acquired (Non-congenital) Immunodeficiency (EBV+ AID LPD)
• EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD)
• EBV+ Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
• Solid Organ Transplant Complications
• Lymphoproliferative Disorders
• Allogeneic Hematopoietic Cell Transplant
• Stem Cell Transplant Complications
• EBV+ Sarcomas
• Leiomyosarcoma

Interventions

• BIOLOGICAL

No Results Yet

NCT04521764 | RECRUITING | PHASE1

54 participants

A Vaccine (MV-s-NAP) for the Treatment of Patients With Invasive Metastatic Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-09-23

Completion:

2027-08-15

Conditions

• Anatomic Stage IV Breast Cancer AJCC v8
• Invasive Breast Carcinoma
• Metastatic Breast Adenocarcinoma
• Recurrent Breast Carcinoma
• Stage IV Breast Cancer AJCC v6 and v7

Interventions

• BIOLOGICAL
• PROCEDURE

No Results Yet

NCT04518748 | ACTIVE_NOT_RECRUITING | PHASE1

70 participants

Combined Y-90 Selective Internal Radiation Therapy (Y-90 SIRT) and Stereotactic Body Radiation Therapy (SBRT) in Hepatic Malignancy.

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-09-16

Completion:

2028-05-31

Conditions

• Liver Malignancy

Interventions

• DRUG
• DEVICE
• RADIATION
• DIAGNOSTIC_TEST

No Results Yet

NCT04514497 | ACTIVE_NOT_RECRUITING | PHASE1

29 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-10-20

Completion:

2025-02-15

Conditions

• Metastatic Lung Small Cell Carcinoma
• Metastatic Malignant Solid Neoplasm
• Metastatic Neuroendocrine Carcinoma
• Metastatic Pancreatic Adenocarcinoma
• Stage III Lung Cancer AJCC v8
• Stage III Pancreatic Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8
• Stage IV Pancreatic Cancer AJCC v8
• Unresectable Lung Small Cell Carcinoma
• Unresectable Malignant Solid Neoplasm
• Unresectable Neuroendocrine Carcinoma
• Unresectable Pancreatic Adenocarcinoma

Interventions

• PROCEDURE
• DRUG

Results Available

NCT04491942 | ACTIVE_NOT_RECRUITING | PHASE1

74 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-08-25

Completion:

2027-06-30

Conditions

• Advanced Bile Duct Carcinoma
• Advanced Breast Carcinoma
• Advanced Cervical Carcinoma
• Advanced Endometrial Carcinoma
• Advanced Esophageal Carcinoma
• Advanced Gastric Carcinoma
• Advanced Head and Neck Carcinoma
• Advanced Lung Non-Small Cell Carcinoma
• Advanced Lung Small Cell Carcinoma
• Advanced Malignant Solid Neoplasm
• Advanced Ovarian Carcinoma
• Advanced Penile Carcinoma
• Advanced Pleural Malignant Mesothelioma
• Advanced Urothelial Carcinoma
• Anatomic Stage III Breast Cancer AJCC v8
• Anatomic Stage IV Breast Cancer AJCC v8
• Clinical Stage III Gastric Cancer AJCC v8
• Clinical Stage IV Gastric Cancer AJCC v8
• Stage III Cervical Cancer AJCC v8
• Stage III Distal Bile Duct Cancer AJCC v8
• Stage III Intrahepatic Bile Duct Cancer AJCC v8
• Stage III Lung Cancer AJCC v8
• Stage III Ovarian Cancer AJCC v8
• Stage III Penile Cancer AJCC v8
• Stage III Pleural Diffuse Malignant Mesothelioma AJCC v8
• Stage IV Cervical Cancer AJCC v8
• Stage IV Distal Bile Duct Cancer AJCC v8
• Stage IV Intrahepatic Bile Duct Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8
• Stage IV Ovarian Cancer AJCC v8
• Stage IV Penile Cancer AJCC v8
• Stage IV Pleural Diffuse Malignant Mesothelioma AJCC v8
• Triple-Negative Breast Carcinoma
• Unresectable Urothelial Carcinoma

Interventions

• DRUG

No Results Yet

NCT04460937 | ACTIVE_NOT_RECRUITING | PHASE1

4 participants

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-04-09

Completion:

2024-03-29

Conditions

• Clinical Stage III Esophageal Adenocarcinoma AJCC v8
• Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8
• Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
• Clinical Stage IV Esophageal Squamous Cell Carcinoma AJCC v8
• Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8
• Clinical Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8
• Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8
• Clinical Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8
• Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Distal Esophagus Adenocarcinoma
• Gastric Cardia Adenocarcinoma
• Metastatic Esophageal Adenocarcinoma
• Metastatic Esophageal Squamous Cell Carcinoma
• Metastatic Gastroesophageal Junction Adenocarcinoma
• Metastatic Malignant Neoplasm in the Brain
• Metastatic Malignant Neoplasm in the Leptomeninges
• Pathologic Stage III Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8
• Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8
• Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8
• Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IV Esophageal Squamous Cell Carcinoma AJCC v8
• Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8
• Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8
• Pathologic Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8
• Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC v8
• Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8
• Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IV Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IV Esophageal Squamous Cell Carcinoma AJCC v8
• Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IVA Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8
• Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IVB Esophageal Adenocarcinoma AJCC v8
• Postneoadjuvant Therapy Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8
• Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
• Unresectable Esophageal Adenocarcinoma
• Unresectable Esophageal Carcinoma
• Unresectable Esophageal Squamous Cell Carcinoma
• Unresectable Gastroesophageal Junction Adenocarcinoma

Interventions

• DRUG
• RADIATION

Results Available

NCT04458922 | ACTIVE_NOT_RECRUITING | PHASE2

27 participants

Testing Atezolizumab in People 2-17 Years Old With Clear Cell Sarcoma or Advanced Chondrosarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-10-05

Completion:

2022-11-28

Conditions

• Central Chondrosarcoma, Grade 2
• Central Chondrosarcoma, Grade 3
• Dedifferentiated Chondrosarcoma
• Metastatic Clear Cell Sarcoma of Soft Tissue
• Metastatic Primary Central Chondrosarcoma
• Unresectable Primary Central Chondrosarcoma

Interventions

• DRUG
• PROCEDURE

Results Available

NCT04401007 | COMPLETED | NA

12 participants

Erector Spinae Plane (ESP) Block Volunteer Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-07-28

Completion:

2023-11-20

Conditions

• Pain Management

Interventions

• OTHER

No Results Yet

NCT04372108 | RECRUITING

1536 participants

A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-31

Start Date:

2021-06-24

Completion:

2029-08-31

Conditions

• Crohn Disease
• Colitis, Ulcerative

Interventions

• DRUG

No Results Yet

NCT04345913 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

24 participants

Testing the Addition of Copanlisib to Eribulin in Metastatic Triple Negative Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-03-01

Completion:

2024-03-28

Conditions

• Anatomic Stage III Breast Cancer AJCC v8
• Anatomic Stage IV Breast Cancer AJCC v8
• Metastatic Triple-Negative Breast Carcinoma
• Unresectable Triple-Negative Breast Carcinoma

Interventions

• PROCEDURE
• DRUG

Results Available

NCT04340843 | ACTIVE_NOT_RECRUITING | PHASE2

19 participants

Testing the Combination of Belinostat and SGI-110 (Guadecitabine) or ASTX727 for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-09-08

Completion:

2024-02-22

Conditions

• Locally Advanced Unresectable Primary Central Chondrosarcoma
• Metastatic Primary Central Chondrosarcoma
• Unresectable Primary Central Chondrosarcoma

Interventions

• DRUG
• PROCEDURE

Results Available

NCT04339738 | ACTIVE_NOT_RECRUITING | PHASE2

90 participants

Testing the Addition of Nivolumab to Chemotherapy in Treatment of Soft Tissue Sarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-11-04

Completion:

2025-03-30

Conditions

• Skin Angiosarcoma
• Skin Radiation-Related Angiosarcoma
• Visceral Angiosarcoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL
• OTHER

Results Available

NCT04322370 | COMPLETED | NA

11 participants

Prospective Randomized Blinded Trial of VersaWrap Tendon Protector for Zone 2 Flexor Tendon Injuries

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-08-21

Completion:

2026-03-31

Conditions

• Flexor Tendon

Interventions

• PROCEDURE
• DEVICE

No Results Yet

NCT04276259 | COMPLETED | PHASE4

120 participants

Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-10-19

Completion:

2026-03-31

Conditions

• Major Depressive Disorder
• Depression

Interventions

• DRUG
• DEVICE

No Results Yet

NCT04234568 | ACTIVE_NOT_RECRUITING | PHASE1

31 participants

Testing the Addition of an Anti-cancer Drug, Triapine, to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Neuroendocrine Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-07-20

Completion:

2024-09-17

Conditions

• Metastatic Digestive System Neuroendocrine Neoplasm
• Metastatic Neuroendocrine Tumor

Interventions

• PROCEDURE
• DRUG

Results Available

NCT04216316 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

12 participants

Testing the Addition of an Anti-cancer Drug, Berzosertib (M6620, VX-970), to the Usual Treatments (Carboplatin and Gemcitabine) and to Pembrolizumab for Patients With Advanced Squamous Cell Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-04-14

Completion:

2024-03-31

Conditions

• Lung Non-Small Cell Squamous Carcinoma
• Stage IV Lung Cancer AJCC v8

Interventions

• DRUG
• PROCEDURE
• BIOLOGICAL

Results Available

NCT04205799 | COMPLETED | PHASE2

57 participants

Cabozantinib for Advanced or Metastatic Cervical Carcinoma After Platinum Treatment Failure

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-01-15

Completion:

2023-01-15

Conditions

• Advanced/Metastatic Cervical Cancer

Interventions

• DRUG

Results Available

NCT04175912 | ACTIVE_NOT_RECRUITING | PHASE2

40 participants

Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-03-16

Completion:

2023-11-27

Conditions

• Metastatic Cholangiocarcinoma
• Metastatic Hepatocellular Carcinoma
• Stage III Hepatocellular Carcinoma AJCC v8
• Stage III Intrahepatic Cholangiocarcinoma AJCC v8
• Stage IIIA Hepatocellular Carcinoma AJCC v8
• Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8
• Stage IIIB Hepatocellular Carcinoma AJCC v8
• Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8
• Stage IV Hepatocellular Carcinoma AJCC v8
• Stage IV Intrahepatic Cholangiocarcinoma AJCC v8
• Stage IVA Hepatocellular Carcinoma AJCC v8
• Stage IVB Hepatocellular Carcinoma AJCC v8
• Unresectable Cholangiocarcinoma
• Unresectable Hepatocellular Carcinoma
• Unresectable Intrahepatic Cholangiocarcinoma

Interventions

• DRUG

Results Available

NCT04175600 | ACTIVE_NOT_RECRUITING | PHASE3

138 participants

A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-01-16

Completion:

2024-10-11

Conditions

• Hypertension, Pulmonary

Interventions

• DRUG

Results Available

NCT04172532 | RECRUITING | PHASE1/PHASE2

92 participants

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-01-11

Completion:

2027-08-01

Conditions

• Locally Advanced Pancreatic Adenocarcinoma
• Stage III Pancreatic Cancer AJCC v8

Interventions

• PROCEDURE
• RADIATION
• DRUG
• OTHER

No Results Yet

NCT04144972 | RECRUITING | NA

12 participants

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2019-10-24

Completion:

2029-10-24

Conditions

• Spinal Cord Injuries
• Nerve Injury
• Pain, Postoperative
• Post Herpetic Neuralgia
• Complex Regional Pain Syndromes
• Post-Stroke Pain
• Post Radiation Brain Injury
• Post Radiation Plexopathy
• Nerve Root Avulsion

Interventions

• DEVICE

No Results Yet

NCT04119050 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

118 participants

Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2019-08-15

Completion:

2025-02-02

Conditions

• Warm Autoimmune Hemolytic Anemia

Interventions

• DRUG

No Results Yet

NCT04093167 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

53 participants

Study of CTDNA Response Adaptive Immuno-Chemotherapy in Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-05-26

Completion:

2026-12-31

Conditions

• Lung Cancer

Interventions

• DRUG

No Results Yet

NCT04090398 | ACTIVE_NOT_RECRUITING | PHASE2

70 participants

Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-08-04

Completion:

2027-06-30

Conditions

• Anatomic Stage IV Breast Cancer AJCC v8
• Metastatic HER2-Negative Breast Carcinoma
• Metastatic Malignant Neoplasm in the Bone

Interventions

• PROCEDURE
• OTHER
• DRUG
• RADIATION

No Results Yet

NCT04079712 | ACTIVE_NOT_RECRUITING | PHASE2

17 participants

Testing the Combination of XL184 (Cabozantinib), Nivolumab, and Ipilimumab for Poorly Differentiated Neuroendocrine Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-08-06

Completion:

2025-01-10

Conditions

• Metastatic Large Cell Neuroendocrine Carcinoma
• Metastatic Neuroendocrine Carcinoma
• Metastatic Neuroendocrine Neoplasm
• Metastatic Small Cell Neuroendocrine Carcinoma

Interventions

• BIOLOGICAL
• DRUG

Results Available

NCT04071223 | ACTIVE_NOT_RECRUITING | PHASE2

134 participants

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-07-29

Completion:

2026-10-01

Conditions

• Advanced Renal Cell Carcinoma
• Chromophobe Renal Cell Carcinoma
• Clear Cell Renal Cell Carcinoma
• Collecting Duct Carcinoma
• Kidney Medullary Carcinoma
• Metastatic Malignant Neoplasm in the Bone
• Papillary Renal Cell Carcinoma
• Stage IV Renal Cell Cancer AJCC v8
• Unclassified Renal Cell Carcinoma

Interventions

• PROCEDURE
• DRUG
• OTHER
• RADIATION

No Results Yet

NCT04052555 | ACTIVE_NOT_RECRUITING | PHASE1

42 participants

Testing the Addition of an Anti-cancer Drug, Berzosertib, to the Usual Treatment (Radiation Therapy) for Chemotherapy-Resistant Triple-Negative and Estrogen and/or Progesterone Receptor Positive, HER2 Negative Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-09-24

Completion:

2027-02-24

Conditions

• Bilateral Breast Carcinoma
• HER2-Negative Breast Carcinoma
• Localized Breast Carcinoma
• Recurrent Breast Carcinoma
• Triple-Negative Breast Carcinoma

Interventions

• DRUG
• PROCEDURE
• OTHER
• RADIATION

No Results Yet

NCT04034927 | ACTIVE_NOT_RECRUITING | PHASE2

61 participants

Testing the Addition of an Immunotherapy Drug, Tremelimumab, to the PARP Inhibition Drug, Olaparib, for Recurrent Ovarian, Fallopian Tube or Peritoneal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2019-12-04

Completion:

2021-07-31

Conditions

• Fallopian Tube Endometrioid Tumor
• Fallopian Tube High Grade Serous Adenocarcinoma
• Malignant Ovarian Endometrioid Tumor
• Ovarian High Grade Serous Adenocarcinoma
• Platinum-Sensitive Fallopian Tube Carcinoma
• Platinum-Sensitive Ovarian Carcinoma
• Platinum-Sensitive Primary Peritoneal Carcinoma
• Primary Peritoneal High Grade Serous Adenocarcinoma
• Recurrent Fallopian Tube Carcinoma
• Recurrent Fallopian Tube Endometrioid Adenocarcinoma
• Recurrent Ovarian Endometrioid Adenocarcinoma
• Recurrent Ovarian Serous Adenocarcinoma
• Recurrent Primary Peritoneal Carcinoma
• Recurrent Primary Peritoneal Endometrioid Adenocarcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

Results Available

NCT03968900 | COMPLETED | NA

29 participants

Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2021-01-01

Completion:

2025-04-01

Conditions

• Smoking
• Sleep Disturbance
• Nicotine Dependence

Interventions

• BEHAVIORAL

Results Available

NCT03945773 | COMPLETED | PHASE2

127 participants

Study of Cabozantinib as 2nd Line Treatment in Subjects With Locally Advanced or Metastatic Renal Cell Carcinoma (RCC) With a Clear-Cell Component Who Progressed After 1st Line Treatment With Checkpoint Inhibitors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-01-08

Completion:

2023-05-11

Conditions

• Locally Advanced or Metastatic Renal Cell Carcinoma

Interventions

• DRUG

Results Available

NCT03914612 | ACTIVE_NOT_RECRUITING | PHASE3

813 participants

Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2019-08-22

Completion:

2022-12-16

Conditions

• Endometrial Clear Cell Adenocarcinoma
• Endometrial Dedifferentiated Carcinoma
• Endometrial Endometrioid Adenocarcinoma
• Endometrial Mixed Cell Adenocarcinoma
• Endometrial Serous Adenocarcinoma
• Endometrial Undifferentiated Carcinoma
• Recurrent Endometrial Adenocarcinoma
• Recurrent Endometrial Carcinoma
• Recurrent Endometrial Clear Cell Adenocarcinoma
• Recurrent Endometrial Dedifferentiated Carcinoma
• Recurrent Endometrial Endometrioid Adenocarcinoma
• Recurrent Endometrial Mixed Cell Adenocarcinoma
• Recurrent Endometrial Serous Adenocarcinoma
• Recurrent Endometrial Undifferentiated Carcinoma
• Stage III Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
• Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

Interventions

• DRUG
• PROCEDURE
• BIOLOGICAL
• OTHER

Results Available

NCT03914300 | ACTIVE_NOT_RECRUITING | PHASE2

11 participants

Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2020-02-10

Completion:

2024-10-17

Conditions

• Differentiated Thyroid Gland Carcinoma
• Follicular Variant Thyroid Gland Papillary Carcinoma
• Poorly Differentiated Thyroid Gland Carcinoma
• Refractory Differentiated Thyroid Gland Carcinoma
• Refractory Thyroid Gland Carcinoma
• Tall Cell Variant Thyroid Gland Papillary Carcinoma
• Thyroid Gland Follicular Carcinoma
• Thyroid Gland Oncocytic Carcinoma
• Thyroid Gland Papillary Carcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

Results Available

NCT03898765 | WITHDRAWN | NA

0 participants

Dry Blood Spot Screening Test for Biliary Atresia（DBS-SCReBA）

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2019-04-01

Completion:

2020-03-31

Conditions

• Hepatobiliary Disease
• Biliary Atresia
• Neonatal Cholestasis

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT03896503 | ACTIVE_NOT_RECRUITING | PHASE2

104 participants

Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2019-12-30

Completion:

2022-12-19

Conditions

• Extensive Stage Lung Small Cell Carcinoma
• Extrapulmonary Small Cell Neuroendocrine Carcinoma
• Limited Stage Lung Small Cell Carcinoma
• Platinum-Resistant Lung Small Cell Carcinoma
• Platinum-Sensitive Lung Small Cell Carcinoma
• Recurrent Lung Small Cell Carcinoma

Interventions

• DRUG
• PROCEDURE

Results Available

NCT03888105 | ACTIVE_NOT_RECRUITING | PHASE2

515 participants

A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2019-11-13

Completion:

2026-06-17

Conditions

• B-cell Non-Hodgkin Lymphoma (B-NHL)

Interventions

• DRUG

No Results Yet

NCT03880019 | ACTIVE_NOT_RECRUITING | PHASE2

23 participants

A Phase II Clinical Trial Evaluating the Combination of Olaparib and Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-31

Start Date:

2019-08-19

Completion:

2020-08-01

Conditions

• Stage III Uterine Corpus Leiomyosarcoma AJCC v8
• Stage IV Uterine Corpus Leiomyosarcoma AJCC v8
• Uterine Corpus Leiomyosarcoma

Interventions

• PROCEDURE
• DRUG

Results Available