Clinical Trials

NCT04494412 | COMPLETED | PHASE2

8 participants

An Intravenous (IV) Zanamivir Pharmacokinetics (PK) Study in Hospitalized Neonates and Infants With Influenza Infection

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2022-11-21
Completion:: 2026-01-14

Conditions

Influenza, Human
Arthralgia

Interventions

DRUG

No Results Yet

NCT04484818 | ACTIVE_NOT_RECRUITING | PHASE3

27 participants

Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-03-01
Completion:: 2026-06-09

Conditions

Prostate Carcinoma

Interventions

DRUG
OTHER

No Results Yet

NCT04463407 | COMPLETED | NA

36 participants

Effect of a Single Nutritional Intervention Previous to a Critical Period of Fat Gain in University Students With Overweight and Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2017-08-28
Completion:: 2017-09-27

Conditions

Obesity

Interventions

OTHER

No Results Yet

NCT04436731 | COMPLETED | EARLY_PHASE1

73 participants

Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-12-09
Completion:: 2026-07-02

Conditions

Obesity
Healthy
Vasoconstriction
Vasodilation

Interventions

OTHER

No Results Yet

NCT04432584 | ACTIVE_NOT_RECRUITING | PHASE3

190 participants

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-09-30
Completion:: 2027-04-18

Conditions

Paroxysmal Nocturnal Hemoglobinuria

Interventions

DRUG

No Results Yet

NCT04392622 | RECRUITING | PHASE1

40 participants

d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-02-15
Completion:: 2027-08-15

Conditions

Xerostomia

Interventions

DRUG
RADIATION
OTHER

No Results Yet

NCT04318886 | ACTIVE_NOT_RECRUITING | PHASE3

387 participants

Lay Coach-Led Early Palliative Care for Underserved Advanced Cancer Caregivers: The Project ENABLE Cornerstone RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-01-07
Completion:: 2025-12-31

Conditions

Cancer Metastatic
Family Members

Interventions

BEHAVIORAL

No Results Yet

NCT04298255 | RECRUITING | NA

50 participants

Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-08-24
Completion:: 2028-07-31

Conditions

Infertility, Male

Interventions

OTHER

No Results Yet

NCT04237545 | COMPLETED | NA

106 participants

A Clinical Study of the T3 Short Dental Implant System

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-01
Completion:: 2026-01-01

Conditions

Edentulous Jaw

Interventions

DEVICE

No Results Yet

NCT04171999 | COMPLETED | NA

660 participants

CommunityRx-Hunger

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-01-06
Completion:: 2023-09-30

Conditions

Food Insecurity

Interventions

OTHER

Results Available

NCT04167514 | COMPLETED | PHASE3

136 participants

Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-01-09
Completion:: 2023-09-11

Conditions

Graft Versus Host Disease (GVHD)

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04162938 | RECRUITING | NA

308 participants

Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2022-03-24
Completion:: 2026-09-30

Conditions

Hepatitis C

Interventions

OTHER

No Results Yet

NCT04160390 | ACTIVE_NOT_RECRUITING

72 participants

Blood Samples to Identify Biomarkers in Patients Treated With Cyclophosphamide After Donor Stem Cell Transplant

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-28
Start Date:: 2018-11-13
Completion:: 2027-04-24

Conditions

Allogeneic Hematopoietic Stem Cell Transplant Recipient
Donor
Malignant Neoplasm

Interventions

OTHER

No Results Yet

NCT04140162 | ACTIVE_NOT_RECRUITING | PHASE2

57 participants

Phase 2 Study With Minimal Residual Disease (MRD) Driven Adaptive Strategy in Treatment for Newly Diagnosed Multiple Myeloma (MM) With Upfront Daratumumab-based Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-10-05
Completion:: 2024-05-02

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT04098471 | RECRUITING | NA

168 participants

Total Meso-rectal Excision Versus Transanal Local Excision Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2021-10-01
Completion:: 2027-06-01

Conditions

Rectal Cancer

Interventions

PROCEDURE

No Results Yet

NCT04093570 | ENROLLING_BY_INVITATION | PHASE2

332 participants

A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-09-30
Completion:: 2027-12-31

Conditions

Acute Myeloid Leukemia
Chronic Myelomonocytic Leukemia
Myelodysplastic Syndromes

Interventions

DRUG

No Results Yet

NCT04069273 | ACTIVE_NOT_RECRUITING | PHASE2

58 participants

Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-12-01
Completion:: 2026-08-11

Conditions

Gastric Cancer
GastroEsophageal Cancer
Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT04058756 | ACTIVE_NOT_RECRUITING | PHASE1

120 participants

Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-30
Completion:: 2030-04-30

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT04055428 | RECRUITING | PHASE2

200 participants

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-08-15
Completion:: 2026-12-31

Conditions

Diabetes Mellitus
Cardiovascular Diseases
Insulin Sensitivity/Resistance
Metabolic Disease
Natriuretic Peptides
Metabolism
Energy Expenditure

Interventions

DRUG
OTHER
DIETARY_SUPPLEMENT

No Results Yet

NCT04040205 | RECRUITING | PHASE2

44 participants

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-07
Completion:: 2027-06-01

Conditions

Chondrosarcoma
Osteosarcoma
Soft Tissue Sarcoma

Interventions

DRUG

No Results Yet

NCT03963375 | COMPLETED | PHASE4

47 participants

Cladribine Tablets: Collaborative Study to Evaluate Impact On Central Nervous System Biomarkers in Multiple Sclerosis

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-28
Completion:: 2025-05-27

Conditions

Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting

Interventions

DRUG

Results Available

NCT03953300 | ACTIVE_NOT_RECRUITING | PHASE4

75 participants

Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-10-08
Completion:: 2026-10-19

Conditions

Asthma

Interventions

BIOLOGICAL

No Results Yet

NCT03945305 | RECRUITING | NA

500 participants

Safety and Efficacy of Remote Ischemic Conditioning Treatment for Community-based Essential Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2023-11-25
Completion:: 2026-07-31

Conditions

Essential Hypertension

Interventions

DEVICE
OTHER

No Results Yet

NCT03899883 | COMPLETED | PHASE2

11 participants

Uric Acid Lowering Trial in Youth Onset T2D

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-01-01
Completion:: 2023-04-13

Conditions

Diabetic Kidney Disease
Hyperuricemia
Diabetes
Diabetes Mellitus, Type 2
Type2 Diabetes
Type 2 Diabetes Mellitus
Diabetic Nephropathies
Diabetes Complications

Interventions

DRUG

Results Available

NCT03893500 | COMPLETED | NA

63 participants

Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2020-07-01
Completion:: 2024-06-01

Conditions

Pulmonary Arterial Hypertension

Interventions

DEVICE

Results Available

NCT03872778 | COMPLETED | PHASE1/PHASE2

35 participants

[177Lu]-NeoB in Patients With Advanced Solid Tumors and With [68Ga]-neoB Lesion Uptake

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-07-24
Completion:: 2025-01-07

Conditions

Neoplasms

Interventions

DRUG

No Results Yet

NCT03814304 | COMPLETED | NA

99 participants

tDCS in Elderly Fallers Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-07-08
Completion:: 2025-01-24

Conditions

Accidental Falls
Aging

Interventions

OTHER

Results Available

NCT03784326 | ACTIVE_NOT_RECRUITING | PHASE2

43 participants

Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-02-19
Completion:: 2026-12-31

Conditions

Clinical Stage II Esophageal Adenocarcinoma AJCC v8
Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8
Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8
Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8
Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8
Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8
Clinical Stage III Esophageal Adenocarcinoma AJCC v8
Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8
Pathologic Stage IB Gastroesophageal Junction Adenocarcinoma AJCC v8
Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8
Pathologic Stage IC Gastroesophageal Junction Adenocarcinoma AJCC v8
Pathologic Stage II Esophageal Adenocarcinoma AJCC v8
Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8
Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8
Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8
Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8
Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8
Pathologic Stage III Esophageal Adenocarcinoma AJCC v8
Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8
Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8
Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8
Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03744715 | TERMINATED | PHASE2

7 participants

A Study to Allow Continued Dosing and/or Follow-up of Patients Who Have Had Previous Exposure to Poziotinib

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2018-10-11
Completion:: 2023-03-03

Conditions

NSCLC
Breast Cancer

Interventions

DRUG

Results Available

NCT03612531 | ACTIVE_NOT_RECRUITING | NA

26 participants

Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2018-08-06
Completion:: 2022-07-15

Conditions

Cancer Survivor
Dysphagia
Fibrosis
Head and Neck Carcinoma

Interventions

PROCEDURE

Results Available

NCT03602599 | COMPLETED

190 participants

Chronic Graft-versus-Host Disease in the Oral Cavity of Patients Following Allogeneic Hematopoietic Stem Cell Transplant and Including Healthy Controls

Study Type:: OBSERVATIONAL
Last Updated:: 2026-07-28
Start Date:: 2018-11-15
Completion:: 2026-05-22

Conditions

Graft Versus Host Disease

No Results Yet

NCT03598608 | TERMINATED | PHASE1/PHASE2

137 participants

Study to Evaluate the Safety and Efficacy of a Combination of Favezelimab (MK-4280) and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies (MK-4280-003)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2018-10-17
Completion:: 2026-01-28

Conditions

Hodgkin Disease
Lymphoma, Non-Hodgkin
Lymphoma, B-Cell

Interventions

BIOLOGICAL

No Results Yet

NCT03581487 | COMPLETED | PHASE1/PHASE2

40 participants

Durvalumab, Tremelimumab, and Selumetinib in Treating Participants With Recurrent or Stage IV Non-small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2019-04-01
Completion:: 2025-10-30

Conditions

Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8
Stage IVA Lung Cancer AJCC v8
Stage IVB Lung Cancer AJCC v8

Interventions

BIOLOGICAL
DRUG

Results Available

NCT03556384 | COMPLETED | PHASE2

23 participants

Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2018-09-12
Completion:: 2023-06-22

Conditions

Gastrointestinal Stromal Tumors
Sdh
GIST
Cancer

Interventions

DRUG

Results Available

NCT03412045 | COMPLETED | NA

8 participants

Hyperbaric Oxygen Therapy in Sickle Cell Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2022-09-01
Completion:: 2025-06-05

Conditions

Vaso-occlusive Crisis
Sickle Cell Anemia Crisis

Interventions

DEVICE

Results Available

NCT03258658 | RECRUITING | PHASE1

10 participants

Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2027-01-31
Completion:: 2029-06-30

Conditions

Urologic Diseases
Male Urogenital Diseases
Urethral Stricture
Urethral Injury

Interventions

BIOLOGICAL

No Results Yet

NCT03180502 | ACTIVE_NOT_RECRUITING | PHASE2

120 participants

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2018-01-23
Completion:: 2026-07-13

Conditions

Anaplastic Astrocytoma
Anaplastic Oligoastrocytoma
Anaplastic Oligodendroglioma
Diffuse Astrocytoma
Glioma
Oligoastrocytoma
Oligodendroglioma
WHO Grade 3 Glioma

Interventions

PROCEDURE
RADIATION
OTHER
DRUG

No Results Yet

NCT03141359 | ACTIVE_NOT_RECRUITING | PHASE2

61 participants

Use of High Dose Radiation Followed by Chemotherapy and Radiation to Treat Locally Advanced NSCLC

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2017-05-12
Completion:: 2023-07-12

Conditions

Lung Cancer Stage II
Lung Cancer Stage III
Non Small Cell Lung Cancer

Interventions

RADIATION
DRUG

Results Available

NCT03109288 | RECRUITING | PHASE1/PHASE2

250 participants

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2017-08-11
Completion:: 2027-01-01

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT03030066 | COMPLETED | PHASE1

47 participants

Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas

Study Type:: INTERVENTIONAL
Last Updated:: 2026-07-28
Start Date:: 2017-01-19
Completion:: 2021-01-31

Conditions

Glioma

Interventions

DRUG

No Results Yet