Clinical Trials

NCT05416372 | SUSPENDED | NA

16046 participants

Engaging Religious Leaders to Reduce Blood Pressures in Tanzanian Communities

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-06-22

Completion:

2025-07-18

Conditions

• Hypertension

Interventions

• BEHAVIORAL

Results Available

NCT05405114 | COMPLETED | PHASE2

96 participants

Research Study Investigating How Well NDec Works in People With Sickle Cell Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-07-07

Completion:

2025-07-24

Conditions

• Sickle Cell Disease

Interventions

• DRUG

No Results Yet

NCT05396248 | RECRUITING | NA

120 participants

Improve New Learning and Memory in Individuals With Mild Cognitive Impairment

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2023-06-28

Completion:

2027-03-31

Conditions

• Mild Cognitive Impairment

Interventions

• BEHAVIORAL

No Results Yet

NCT05359562 | RECRUITING | NA

120 participants

How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-06-15

Completion:

2028-06-30

Conditions

• OCD

Interventions

• BEHAVIORAL

No Results Yet

NCT05351905 | COMPLETED | NA

51 participants

Improving Pain Disability With the Use of Oral Cannabinoids

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-11-22

Completion:

2025-12-31

Conditions

• Chronic Pain
• Opioid Use
• Cannabis

Interventions

• DRUG

No Results Yet

NCT05349682 | ACTIVE_NOT_RECRUITING | NA

12 participants

Bayer OA Knee Pain Pilot

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-10-01

Completion:

2026-12-31

Conditions

• Osteoarthritis, Knee

Interventions

• DIAGNOSTIC_TEST
• PROCEDURE

No Results Yet

NCT05277571 | COMPLETED | PHASE1/PHASE2

109 participants

A Single-ascending Dose (Part A) and Repeat-dose (Part B) Study to Investigate the Safety, Pharmacokinetics and Efficacy (Part B Only) of UCB1381 in Healthy Study Participants (Part A) and in Study Participants With Moderate to Severe Atopic Dermatitis (Part B)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-03-07

Completion:

2025-07-17

Conditions

• Atopic Dermatitis

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT05266417 | RECRUITING | PHASE2

56 participants

Intranasal Insulin and Glutathione as an Add-On Therapy in Parkinson's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-02-07

Completion:

2027-09-01

Conditions

• Parkinson Disease

Interventions

• DRUG

No Results Yet

NCT05256290 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

200 participants

Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-03-31

Completion:

2025-11-03

Conditions

• Non-Small Cell Lung Cancer
• Advanced Non-Small Cell Squamous Lung Cancer
• Metastatic Lung Non-Small Cell Carcinoma
• Metastatic Lung Cancer
• NSCLC
• Advanced Lung Carcinoma
• Epidermal Growth Factor Receptor C797S
• Epidermal Growth Factor Receptor G719X
• EGF-R Positive Non-Small Cell Lung Cancer
• EGFR-TKI Resistant Mutation

Interventions

• DRUG

No Results Yet

NCT05253651 | RECRUITING | PHASE3

400 participants

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-10-24

Completion:

2027-12-31

Conditions

• Colorectal Neoplasms

Interventions

• DRUG

No Results Yet

NCT05245643 | ACTIVE_NOT_RECRUITING | NA

12 participants

Deep Brain Stimulation for Severe Anorexia Nervosa

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-04-14

Completion:

2027-12-10

Conditions

• Anorexia Nervosa

Interventions

• DEVICE

No Results Yet

NCT05227053 | RECRUITING

200 participants

STOP AF First Post-Approval Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2022-04-28

Completion:

2028-04-30

Conditions

• Paroxysmal Atrial Fibrillation

Interventions

• DEVICE

No Results Yet

NCT05208762 | RECRUITING | PHASE1

714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-10-25

Completion:

2028-01-05

Conditions

• Carcinoma, Non-Small-Cell Lung
• Squamous Cell Carcinoma of the Head and Neck
• Esophageal Squamous Cell Carcinoma
• Triple Negative Breast Neoplasms
• Gastric Cancer
• Endometrial Cancer
• Pancreatic Adenocarcinoma
• Hepatocellular Carcinoma

Interventions

• DRUG

No Results Yet

NCT05198934 | COMPLETED | PHASE3

160 participants

Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C Mutation

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-04-19

Completion:

2025-07-16

Conditions

• Colorectal Cancer (CRC)

Interventions

• DRUG

Results Available

NCT05188508 | RECRUITING | PHASE2

57 participants

Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-01-14

Completion:

2027-01-31

Conditions

• Glioma

Interventions

• DRUG
• COMBINATION_PRODUCT

No Results Yet

NCT05186636 | COMPLETED

9348 participants

Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2023-01-12

Completion:

2026-05-31

Conditions

• Acute Renal Injury

Interventions

• OTHER

No Results Yet

NCT05184361 | COMPLETED | NA

75 participants

Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-01-13

Completion:

2024-06-30

Conditions

• Obesity
• Weight Loss

Interventions

• BEHAVIORAL

No Results Yet

NCT05177393 | RECRUITING

2476 participants

Treatment Outcomes of Esophageal Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2019-02-28

Completion:

2027-06-30

Conditions

• Esophageal Cancer

Interventions

• OTHER

No Results Yet

NCT05167409 | TERMINATED | PHASE2

19 participants

Study of Evorpacept (ALX148) With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-07-28

Completion:

2024-10-30

Conditions

• Microsatellite Stable Metastatic Colorectal Cancer

Interventions

• DRUG

Results Available

NCT05143840 | ACTIVE_NOT_RECRUITING | PHASE2

100 participants

Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-04-22

Completion:

2032-02-29

Conditions

• Chronic Myeloid Leukemia, Chronic Phase
• Adult CML
• Leukemia, Myeloid
• Leukemia,Myeloid, Chronic

Interventions

• DRUG
• COMBINATION_PRODUCT
• OTHER

No Results Yet

NCT05142189 | RECRUITING | PHASE1

320 participants

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-06-17

Completion:

2030-02-28

Conditions

• Non-Small Cell Lung Cancer

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT05139797 | RECRUITING

300 participants

Artificial Intelligence Guided Echocardiographic Screening of Rare Diseases (EchoNet-Screening)

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2021-11-18

Completion:

2027-01-01

Conditions

• Cardiac Amyloidosis

Interventions

• OTHER

No Results Yet

NCT05132582 | ACTIVE_NOT_RECRUITING | PHASE3

654 participants

A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-03-07

Completion:

2025-09-05

Conditions

• HER2 Positive Breast Cancer

Interventions

• DRUG

No Results Yet

NCT05098210 | RECRUITING | PHASE1

28 participants

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-06-09

Completion:

2027-11-01

Conditions

• Anatomic Stage IV Breast Cancer AJCC v8
• Clinical Stage IV Cutaneous Melanoma AJCC v8
• Locally Advanced Cutaneous Melanoma
• Locally Advanced Mucosal Melanoma
• Metastatic Acral Melanoma
• Metastatic Conjunctival Melanoma
• Metastatic Cutaneous Melanoma
• Metastatic HER2-Negative Breast Carcinoma
• Metastatic Hormone Receptor-Positive Breast Carcinoma
• Metastatic Lung Non-Small Cell Carcinoma
• Metastatic Malignant Solid Neoplasm
• Metastatic Mucosal Melanoma
• Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
• Pathologic Stage IIID Cutaneous Melanoma AJCC v8
• Recurrent Cutaneous Melanoma
• Recurrent HER2-Negative Breast Carcinoma
• Recurrent Hormone Receptor-Positive Breast Carcinoma
• Recurrent Lung Non-Small Cell Carcinoma
• Recurrent Mucosal Melanoma
• Stage III Lung Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8
• Unresectable Acral Melanoma
• Unresectable Cutaneous Melanoma
• Unresectable Lung Non-Small Cell Carcinoma
• Unresectable Mucosal Melanoma

Interventions

• BIOLOGICAL
• DRUG
• PROCEDURE

No Results Yet

NCT05086978 | ENROLLING_BY_INVITATION

250 participants

Novel Clinical Utility of Retinal Imaging in Patients With Heart Failure

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2022-02-01

Completion:

2027-12-31

Conditions

• Heart Failure

No Results Yet

NCT05079984 | COMPLETED | NA

108 participants

Agile Development of a Digital Exposure Treatment for Youth With Chronic Musculoskeletal Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-05-02

Completion:

2025-05-13

Conditions

• Chronic Pain
• Exposure
• Adolescent Behavior
• Child Behavior

Interventions

• BEHAVIORAL

Results Available

NCT05060341 | ACTIVE_NOT_RECRUITING

22 participants

Long-Term Follow-Up Study of AAV2hAQP1 for Radiation Induced Xerostomia

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2020-11-12

Completion:

2027-03-31

Conditions

• Radiation-induced Xerostomia

No Results Yet

NCT05060016 | ACTIVE_NOT_RECRUITING | PHASE2

222 participants

A Phase 2 Study of Tarlatamab in Patients With Small Cell Lung Cancer (SCLC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-12-01

Completion:

2027-12-30

Conditions

• Relapsed/Refractory Small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT05058508 | RECRUITING | NA

60 participants

LCI-PED-NOS-EXER-001: Exercise in Pediatric Oncology Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2024-03-11

Completion:

2027-11-30

Conditions

• Pediatric Cancer

Interventions

• OTHER

No Results Yet

NCT05045794 | COMPLETED | NA

228 participants

Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-12-16

Completion:

2023-05-19

Conditions

• End Stage Liver DIsease
• Liver Failure

Interventions

• DEVICE
• OTHER

Results Available

NCT05032105 | ACTIVE_NOT_RECRUITING | PHASE1

2 participants

The Impact of Focused Ultrasound Thalamotomy of the Anterior Nucleus for Focal-Onset Epilepsy on Anxiety

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2024-06-04

Completion:

2027-12-31

Conditions

• Anxiety
• Medication-refractory Focal-onset Epilepsy

Interventions

• DEVICE

No Results Yet

NCT05024760 | COMPLETED | EARLY_PHASE1

97 participants

Antiseptic Effects on the Dental Implant Internal Surface Microbiome

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-07-28

Completion:

2025-12-31

Conditions

• Peri-Implantitis
• Peri-implant Mucositis
• Implant Infection
• Dental Implant Failed

Interventions

• DRUG

No Results Yet

NCT05013905 | COMPLETED | PHASE2

55 participants

A Phase 2a Safety and Efficacy Open-Label Study of Tulisokibart (MK-7240/PRA023) in Participants With Moderately to Severely Active Crohn's Disease (MK-7240-006)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-07-28

Completion:

2022-09-23

Conditions

• Crohn Disease

Interventions

• BIOLOGICAL
• DIAGNOSTIC_TEST

Results Available

NCT05005949 | ACTIVE_NOT_RECRUITING

400 participants

STOP Persistent AF PAS

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2021-08-19

Completion:

2028-07-31

Conditions

• Persistent Atrial Fibrillation

Interventions

• DEVICE

No Results Yet

NCT04989725 | RECRUITING | PHASE2

46 participants

Stereotactic Ablative Radiotherapy for Oligo-Progressive Disease REfractory to Systemic Therapy in Metastatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-10-01

Completion:

2027-03-01

Conditions

• Metastatic Cancer
• Oligoprogressive

Interventions

• OTHER
• RADIATION

No Results Yet

NCT04975308 | ACTIVE_NOT_RECRUITING | PHASE3

874 participants

A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-10-04

Completion:

2024-06-24

Conditions

• Breast Neoplasms
• Neoplasm Metastasis

Interventions

• DRUG

Results Available

NCT04970056 | RECRUITING

20000 participants

Pancreatic Cancer Early Detection Consortium

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-22

Start Date:

2020-09-18

Completion:

2030-12-31

Conditions

• Pancreas Cancer
• Pancreas Cyst
• Pancreatic Ductal Adenocarcinoma
• Genetic Predisposition

No Results Yet

NCT04967170 | COMPLETED | PHASE1/PHASE2

30 participants

A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen Sclerosus

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-01-19

Completion:

2025-12-12

Conditions

• Vulvar Lichen Sclerosus

Interventions

• BIOLOGICAL
• OTHER

No Results Yet

NCT04957095 | RECRUITING | NA

120 participants

Motor Network Physiology

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2022-02-18

Completion:

2027-12-01

Conditions

• Parkinson Disease
• Essential Tremor

Interventions

• DRUG
• OTHER

No Results Yet

NCT04950127 | COMPLETED | PHASE3

238 participants

Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-22

Start Date:

2021-08-27

Completion:

2024-10-28

Conditions

• Pruritus

Interventions

• DRUG

Results Available