Clinical Trials

NCT04439357 | ACTIVE_NOT_RECRUITING | PHASE2

4 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With GNAQ or GNA11 Genetic Changes (MATCH-Subprotocol S2)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2016-02-25

Completion:

2020-09-01

Conditions

• Advanced Lymphoma
• Advanced Malignant Solid Neoplasm
• Hematopoietic and Lymphoid Cell Neoplasm
• Refractory Lymphoma
• Refractory Malignant Solid Neoplasm
• Refractory Multiple Myeloma

Interventions

• DRUG

Results Available

NCT04439318 | ACTIVE_NOT_RECRUITING | PHASE2

50 participants

Testing Trametinib as a Potential Targeted Treatment in Cancers With NF1 Genetic Changes (MATCH-Subprotocol S1)

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2016-02-25

Completion:

2020-06-30

Conditions

• Advanced Lymphoma
• Advanced Malignant Solid Neoplasm
• Hematopoietic and Lymphoid Cell Neoplasm
• Refractory Lymphoma
• Refractory Malignant Solid Neoplasm
• Refractory Multiple Myeloma

Interventions

• DRUG

Results Available

NCT04430218 | RECRUITING | NA

15 participants

Peripheral Interfaces in Amputees for Sensorimotor Integration

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2020-08-18

Completion:

2032-06-30

Conditions

• Upper Extremity Amputee

Interventions

• DEVICE

No Results Yet

NCT04395079 | ACTIVE_NOT_RECRUITING | PHASE2

9 participants

Brachytherapy With Durvalumab or Tremelimumab for the Treatment of Patients With Platinum-Resistant, Refractory, Recurrent, or Metastatic Gynecological Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2020-08-07

Completion:

2024-10-11

Conditions

• Metastatic Malignant Female Reproductive System Neoplasm
• Platinum-Resistant Malignant Female Reproductive System Neoplasm
• Recurrent Malignant Female Reproductive System Neoplasm
• Refractory Malignant Female Reproductive System Neoplasm

Interventions

• BIOLOGICAL
• RADIATION

No Results Yet

NCT04375384 | RECRUITING | PHASE2

38 participants

Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2020-07-01

Completion:

2026-12-31

Conditions

• Head and Neck Squamous Cell Carcinoma
• Recurrent Head and Neck Squamous Cell Carcinoma
• Metastatic Head-and-neck Squamous-cell Carcinoma

Interventions

• DRUG
• OTHER

No Results Yet

NCT04363164 | RECRUITING | PHASE2

150 participants

Sequential Testosterone and Enzalutamide Prevents Unfavorable Progression

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2020-08-19

Completion:

2027-07-31

Conditions

• Castration Resistant Metastatic Prostate Cancer

Interventions

• DRUG

No Results Yet

NCT04360265 | ENROLLING_BY_INVITATION | PHASE3

41 participants

Follow-up Study of AAV-Mediated Gene Transfer (UX111; Previously Known as ABO-102) for MPS Type IIIA

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2020-09-28

Completion:

2027-08-31

Conditions

• Mucopolysaccharidosis IIIA
• MPS IIIA
• Sanfilippo Syndrome
• Sanfilippo A

Interventions

• OTHER
• DRUG

No Results Yet

NCT04330599 | RECRUITING

13000 participants

Longitudinal Population-based Observational Study of COVID-19 in the UK Population

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-17

Start Date:

2020-04-27

Completion:

2026-07-27

Conditions

• COVID-19

No Results Yet

NCT04316546 | ACTIVE_NOT_RECRUITING | PHASE2

38 participants

MK-7075 (Miransertib) in Proteus Syndrome

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2022-05-20

Completion:

2026-06-25

Conditions

• Proteus Syndrome

Interventions

• DRUG

No Results Yet

NCT04303182 | COMPLETED | NA

200 participants

LESS TEP vs. Three Port TEP for Inguinal Hernia Repair

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2020-01-02

Completion:

2021-01-01

Conditions

• Inguinal Hernia

Interventions

• PROCEDURE

Results Available

NCT04299113 | ACTIVE_NOT_RECRUITING | PHASE1

14 participants

Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2020-05-14

Completion:

2026-12-30

Conditions

• Rhabdomyosarcoma

Interventions

• DRUG

No Results Yet

NCT04285671 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

30 participants

Necitumumab and Trastuzumab in Combination With Osimertinib for the Treatment of Refractory Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2021-01-29

Completion:

2026-12-02

Conditions

• Metastatic Lung Non-Small Cell Carcinoma
• Refractory Lung Non-Small Cell Carcinoma
• Stage IV Lung Cancer American Joint Committee on Cancer (AJCC) v8
• Stage IVA Lung Cancer AJCC v8
• Stage IVB Lung Cancer AJCC v8

Interventions

• BIOLOGICAL
• DRUG
• OTHER

No Results Yet

NCT04230109 | RECRUITING | PHASE2

239 participants

Sacituzumab Govitecan In TNBC

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2020-07-14

Completion:

2028-10-31

Conditions

• Invasive Breast Cancer
• Triple Negative Breast Cancer
• ER-Negative Breast Cancer
• PR-Negative Breast Cancer
• HER2-negative Breast Cancer

Interventions

• DRUG

No Results Yet

NCT04190251 | COMPLETED | NA

73 participants

PANDIA IRIS: Patients With Diabetes and Kidney Failure, an Interdisciplinary Medication Adherence Support Program

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2016-04-14

Completion:

2022-12-20

Conditions

• Diabetes Mellitus, Type 2
• Renal Insufficiency, Chronic

Interventions

• OTHER

No Results Yet

NCT04188899 | NOT_YET_RECRUITING

150 participants

Point-of-care Ultrasound in the Assessment of Snake Bite

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-17

Start Date:

2026-08-31

Completion:

2029-08-31

Conditions

• Rattlesnake Bite (Diagnosis)

No Results Yet

NCT04122456 | RECRUITING | NA

48 participants

DNA Repair Activity in the Skin of Day and Night Shift Workers

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2022-12-07

Completion:

2027-12-31

Conditions

• Skin Cancer

Interventions

• RADIATION
• OTHER

No Results Yet

NCT04115631 | ACTIVE_NOT_RECRUITING | PHASE2

360 participants

A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2019-12-13

Completion:

2026-12-31

Conditions

• Liver Lymphoma
• Mantle Cell Lymphoma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04090411 | COMPLETED | PHASE2

246 participants

A Study to Evaluate the Efficacy and Safety of PF-06480605 in Adults With Moderate to Severe Ulcerative Colitis

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2019-12-19

Completion:

2022-10-25

Conditions

• Moderate to Severe Ulcerative Colitis

Interventions

• DRUG
• OTHER

Results Available

NCT04047342 | COMPLETED

824 participants

Assessing the Impact of myHealth Rewards New Hire Enrollment Emails

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-17

Start Date:

2019-07-16

Completion:

2019-12-20

Conditions

• Health Promotion
• Wellness Programs

Interventions

• BEHAVIORAL

Results Available

NCT03950427 | COMPLETED | PHASE4

108 participants

PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2019-07-08

Completion:

2025-07-30

Conditions

• Smoking Cessation
• Smoking, Tobacco
• Mental Illness
• Tobacco Use Disorder

Interventions

• BEHAVIORAL
• DRUG

Results Available

NCT03938324 | COMPLETED | NA

222 participants

Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2019-10-29

Completion:

2024-06-19

Conditions

• Sickle Cell Disease
• Chronic Kidney Diseases
• Systemic Lupus Erythematosus
• Childhood Cancer
• Inflammatory Bowel Diseases
• Stem Cell Transplant
• Organ Transplant
• Diabetes Mellitus, Type 1
• Cystic Fibrosis

Interventions

• BEHAVIORAL

Results Available

NCT03935906 | COMPLETED | NA

1410 participants

Reaching mEthadone Users Attending Community pHarmacies With HCV

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2019-10-08

Completion:

2021-01-14

Conditions

• Hepatitis C

Interventions

• OTHER

Results Available

NCT03906253 | RECRUITING | NA

72 participants

Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2018-01-10

Completion:

2028-12-31

Conditions

• Actinic Keratoses
• Aging
• Non-Melanoma Skin Cancer

Interventions

• DEVICE

No Results Yet

NCT03841097 | ACTIVE_NOT_RECRUITING | PHASE4

60 participants

Pulse Wave Velocity, Tacrolimus Time in Therapeutic Range and CV in African American Kidney Transplants

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2019-11-11

Completion:

2026-12-31

Conditions

• Kidney Transplant; Complications

Interventions

• DRUG

No Results Yet

NCT03827941 | RECRUITING | NA

40 participants

Auricular Transcutaneous Electrical Nerve Stimulation Treatment of Autism

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2022-11-01

Completion:

2027-09-28

Conditions

• Autism Spectrum Disorder

Interventions

• OTHER

No Results Yet

NCT03804255 | WITHDRAWN

0 participants

Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-17

Start Date:

2019-01-08

Completion:

2020-05-29

Conditions

• Breast Carcinoma
• Colorectal Carcinoma
• Community Practice
• Lung Carcinoma
• Melanoma
• Solid Neoplasm

Interventions

• OTHER

No Results Yet

NCT03732677 | ACTIVE_NOT_RECRUITING | PHASE3

1063 participants

Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2018-11-16

Completion:

2024-04-29

Conditions

• Muscle Invasive Bladder Cancer

Interventions

• DRUG

Results Available

NCT03718260 | COMPLETED | NA

9684 participants

PSMA-PET Registry for Recurrent Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2018-09-27

Completion:

2026-06-15

Conditions

• Recurrent Prostate Cancer

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT03697148 | ACTIVE_NOT_RECRUITING | NA

852 participants

Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2019-02-11

Completion:

2026-12-31

Conditions

• Prostate Carcinoma

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT03516279 | ACTIVE_NOT_RECRUITING | PHASE2

40 participants

Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2019-06-26

Completion:

2028-08-31

Conditions

• Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
• Minimal Residual Disease

Interventions

• DRUG
• OTHER
• BIOLOGICAL

No Results Yet

NCT03510442 | RECRUITING

2000 participants

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions

Study Type:

OBSERVATIONAL

Last Updated:

2026-07-17

Start Date:

2018-05-21

Completion:

2050-01-01

Conditions

• Still's Disease, Adult-Onset
• Systemic Inflammation
• Arthritis
• Autoinflammatory Syndrome

No Results Yet

NCT03504163 | ACTIVE_NOT_RECRUITING | PHASE2

45 participants

Pembrolizumab (MK-3475) and Bacillus Calmette-Guérin (BCG) as First-Line Treatment for High-Risk T1 Non-Muscle-Invasive Bladder Cancer (NMIBC) and High-Grade Non-Muscle-Invasive Upper Tract Urothelial Carcinoma (NMI-UTUC)]

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2018-06-27

Completion:

2027-04-30

Conditions

• Bladder Cancer

Interventions

• DRUG

No Results Yet

NCT03480360 | COMPLETED | PHASE3

21 participants

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2018-03-28

Completion:

2025-02-14

Conditions

• Acute Myeloid Leukemia
• Chronic Lymphocytic Leukemia
• Chronic Myeloid Leukemia
• Myelodysplasia
• Myeloproliferative Disorder
• Myelofibrosis
• Lymphoma
• Lymphoma, Non-Hodgkin
• Plasma Cell Disorder

Interventions

• DRUG
• RADIATION
• PROCEDURE

Results Available

NCT03427138 | TERMINATED | NA

89 participants

Training Early Social Language in Autism

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2016-07-01

Completion:

2022-08-31

Conditions

• Autism Spectrum Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT03423628 | ACTIVE_NOT_RECRUITING | PHASE1

159 participants

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2018-04-02

Completion:

2026-09-03

Conditions

• Recurrent Glioblastoma Multiforme
• Primary Glioblastoma Multiforme
• Brain Neoplasms, Malignant
• Leptomeningeal Disease (LMD)

Interventions

• RADIATION
• DRUG

No Results Yet

NCT03383302 | COMPLETED | PHASE1/PHASE2

36 participants

SBRT With Immunotherapy in Early Stage Non-small Cell Lung Cancer: Tolerability and Lung Effects

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2018-02-08

Completion:

2024-08-12

Conditions

• Non-small Cell Lung Cancer Stage II
• Non-small Cell Lung Cancer Stage I

Interventions

• RADIATION
• DRUG

Results Available

NCT03314688 | COMPLETED | NA

173 participants

Lifestyle, Exercise, and Nutrition Study Early After Diagnosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2018-01-02

Completion:

2023-03-24

Conditions

• Breast Neoplasms

Interventions

• BEHAVIORAL

Results Available

NCT03267433 | ACTIVE_NOT_RECRUITING | PHASE3

689 participants

Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual Disease-Negative Mantle Cell Lymphoma in First Complete Remission

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2017-11-27

Completion:

2027-01-31

Conditions

• Mantle Cell Lymphoma

Interventions

• PROCEDURE
• BIOLOGICAL

No Results Yet

NCT03230747 | ACTIVE_NOT_RECRUITING | NA

72 participants

SAPIEN M3 EFS: Early Feasibility Study of the Edwards SAPIEN M3 System for the Treatment of Mitral Regurgitation

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2017-09-14

Completion:

2021-06-16

Conditions

• Mitral Regurgitation
• Mitral Disease

Interventions

• DEVICE

No Results Yet

NCT03115333 | ACTIVE_NOT_RECRUITING | NA

146 participants

DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-07-17

Start Date:

2017-07-25

Completion:

2025-12-31

Conditions

• Gliosarcoma
• Recurrent Glioblastoma

Interventions

• DIAGNOSTIC_TEST

No Results Yet