Clinical Trials

NCT04533750 | ACTIVE_NOT_RECRUITING | PHASE1
21 participants

Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2021-12-20
Completion:
2025-12-07
Conditions
  • Advanced Head and Neck Squamous Cell Carcinoma
  • Advanced Hypopharyngeal Squamous Cell Carcinoma
  • Advanced Laryngeal Squamous Cell Carcinoma
  • Advanced Oral Cavity Squamous Cell Carcinoma
  • Advanced Oropharyngeal Squamous Cell Carcinoma
  • Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
  • Stage III Hypopharyngeal Carcinoma AJCC v8
  • Stage III Laryngeal Cancer AJCC v8
  • Stage III Lip and Oral Cavity Cancer AJCC v8
  • Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8
  • Stage IVA Hypopharyngeal Carcinoma AJCC v8
  • Stage IVA Laryngeal Cancer AJCC v8
  • Stage IVA Lip and Oral Cavity Cancer AJCC v8
  • Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8
  • Stage IVB Hypopharyngeal Carcinoma AJCC v8
  • Stage IVB Laryngeal Cancer AJCC v8
  • Stage IVB Lip and Oral Cavity Cancer AJCC v8
  • Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions
  • PROCEDURE
  • OTHER
  • RADIATION
  • DRUG
No Results Yet
NCT04317105 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
54 participants

Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2020-07-17
Completion:
2025-10-01
Conditions
  • Advanced Malignant Solid Neoplasm
  • Metastatic Malignant Solid Neoplasm
  • Unresectable Malignant Solid Neoplasm
Interventions
  • PROCEDURE
  • DRUG
  • BIOLOGICAL
No Results Yet
NCT04197713 | ACTIVE_NOT_RECRUITING | PHASE1
13 participants

Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2020-06-30
Completion:
2023-02-22
Conditions
  • Advanced Malignant Solid Neoplasm
  • Metastatic Malignant Solid Neoplasm
  • Refractory Malignant Solid Neoplasm
  • Unresectable Malignant Solid Neoplasm
Interventions
  • DRUG
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