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Tromsø Birch Rust Allergy Study. Allergy to Birch Rust, a Possible Explanation to Seasonal Airway Allergy During Autumn?

NCT04322838 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2021-04-28

No results posted yet for this study

Summary

In this project we study if spores from birch rust fungi (Melampsoridium Betulinum = MB) may be the eliciting allergen in patients with seasonal airway allergy during autumn in North Norway. Patients with suspected allergy to MB are compared with non-allergic controls using data about allergic disease and daily allergic symptoms during autumn. Daily spread of MB spores are compared with daily variations in allergic symptoms. Sensitization to MB and MB allergy are tested with skin prick test, specific immunoglobulin E (IgE) in serum, nasal provocation test and basophil activation test (BAT).

Conditions

  • Hypersensitivity, Immediate
  • Allergy

Interventions

DIAGNOSTIC_TEST

MeDALL questionnaire for allergic diseases

Questionnaire about allergic symptoms and disease

DIAGNOSTIC_TEST

Registration of allergic symptoms

Daily registration of allergic symptoms from eyes, nose and lungs on scale from 0-10 and daily registration of use of anti allergic medication from 1st of August to 15th of October.

DIAGNOSTIC_TEST

Skin Prick Test

Diagnostic skin test for sensitization to allergens

DIAGNOSTIC_TEST

Specific IgE in serum

Diagnostic test for sensitization to allergens in serum

DIAGNOSTIC_TEST

Nasal provocation test

Diagnostic test for allergic rhinitis. Patients and controls are exposed to an allergen with a nasal spray. Allergic reactions are measured with Linder score and Pean Nasal Inspiratory Flow (PNIF)

DIAGNOSTIC_TEST

Basophil Activation Test

Basophil leukocytes are extracted from full blood and exposed to 6 different doses of allergen and activation of basophils are measured.

Sponsors & Collaborators

  • Luxembourg Institute of Health

    collaborator OTHER_GOV

  • Oslo University Hospital

    collaborator OTHER

  • University Hospital of North Norway

    lead OTHER

Principal Investigators

  • Martin Sørensen, PhD · University Hospital of North Norway

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-01
Primary Completion
2021-12-01
Completion
2021-12-01

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04322838 on ClinicalTrials.gov