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Clinical Trials

NCT03210714 | ACTIVE_NOT_RECRUITING | PHASE2
20 participants

Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2018-06-05
Completion:
2023-09-30
Conditions
  • Advanced Malignant Solid Neoplasm
  • Recurrent Childhood Ependymoma
  • Recurrent Childhood Malignant Germ Cell Tumor
  • Recurrent Childhood Medulloblastoma
  • Recurrent Childhood Non-Hodgkin Lymphoma
  • Recurrent Childhood Osteosarcoma
  • Recurrent Childhood Rhabdomyosarcoma
  • Recurrent Childhood Soft Tissue Sarcoma
  • Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
  • Recurrent Hepatoblastoma
  • Recurrent Langerhans Cell Histiocytosis
  • Recurrent Malignant Glioma
  • Recurrent Malignant Solid Neoplasm
  • Recurrent Neuroblastoma
  • Recurrent Primary Central Nervous System Neoplasm
  • Recurrent Rhabdoid Tumor
  • Refractory Childhood Malignant Germ Cell Tumor
  • Refractory Childhood Osteosarcoma
  • Refractory Childhood Rhabdomyosarcoma
  • Refractory Childhood Soft Tissue Sarcoma
  • Refractory Ependymoma
  • Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
  • Refractory Hepatoblastoma
  • Refractory Langerhans Cell Histiocytosis
  • Refractory Malignant Glioma
  • Refractory Malignant Solid Neoplasm
  • Refractory Medulloblastoma
  • Refractory Neuroblastoma
  • Refractory Non-Hodgkin Lymphoma
  • Refractory Primary Central Nervous System Neoplasm
  • Refractory Rhabdoid Tumor
  • Wilms Tumor
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
Results Available
NCT03050268 | RECRUITING
1500 participants

Familial Investigations of Childhood Cancer Predisposition

Study Type:
OBSERVATIONAL
Last Updated:
2026-06-17
Start Date:
2017-04-06
Completion:
2037-03-31
Conditions
  • Acute Leukemia
  • Adenomatous Polyposis
  • Adrenocortical Carcinoma
  • AML
  • BAP1 Tumor Predisposition Syndrome
  • Carney Complex
  • Choroid Plexus Carcinoma
  • Constitutional Mismatch Repair Deficiency Syndrome
  • Diamond-Blackfan Anemia
  • DICER1 Syndrome
  • Dyskeratosis Congenita
  • Emberger Syndrome
  • Familial Acute Myeloid Leukemia
  • Familial Adenomatous Polyposis
  • Fanconi Anemia
  • Familial Cancer
  • Familial Wilms Tumor
  • Familial Neuroblastoma
  • GIST
  • Hereditary Breast and Ovarian Cancer
  • Hereditary Paraganglioma-Pheochromocytoma Syndrome
  • Hodgkin Lymphoma
  • Juvenile Polyposis
  • Li-Fraumeni Syndrome
  • Lynch Syndrome
  • MDS
  • Melanoma Syndrome
  • Multiple Endocrine Neoplasia Type 1
  • Multiple Endocrine Neoplasia Type 2
  • Neuroblastoma
  • Neurofibromatosis Type 1
  • Neurofibromatosis Type II
  • Nevoid Basal Cell Carcinoma Syndrome
  • Non Hodgkin Lymphoma
  • Noonan Syndrome and Other Rasopathy
  • Overgrowth Syndromes
  • Pancreatic Cancer
  • Peutz-Jeghers Syndrome
  • Pheochromocytoma/Paraganglioma
  • PTEN Hamartoma Tumor Syndrome
  • Retinoblastoma
  • Rhabdoid Tumor Predisposition Syndrome
  • Rhabdomyosarcoma
  • Rothmund-Thomson Syndrome
  • Tuberous Sclerosis
  • Von Hippel-Lindau Disease
No Results Yet
NCT02996396 | COMPLETED
48 participants

Nellix Registry Study: EVAS-Global

Study Type:
OBSERVATIONAL
Last Updated:
2026-06-17
Start Date:
2016-11-30
Completion:
2023-04-25
Conditions
  • Abdominal Aortic Aneurysm
Interventions
  • DEVICE
No Results Yet
NCT02834013 | ACTIVE_NOT_RECRUITING | PHASE2
798 participants

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2017-01-30
Completion:
2026-05-01
Conditions
  • Acinar Cell Carcinoma
  • Adenoid Cystic Carcinoma
  • Adrenal Cortical Carcinoma
  • Adrenal Gland Pheochromocytoma
  • Anal Canal Neuroendocrine Carcinoma
  • Anal Canal Undifferentiated Carcinoma
  • Angiosarcoma
  • Apocrine Neoplasm
  • Appendix Mucinous Adenocarcinoma
  • Bartholin Gland Transitional Cell Carcinoma
  • Basal Cell Carcinoma
  • Bladder Adenocarcinoma
  • Breast Metaplastic Carcinoma
  • Cervical Adenocarcinoma
  • Cholangiocarcinoma
  • Chordoma
  • Colorectal Squamous Cell Carcinoma
  • Desmoid Fibromatosis
  • Endometrial Transitional Cell Carcinoma
  • Endometrioid Adenocarcinoma
  • Esophageal Neuroendocrine Carcinoma
  • Esophageal Undifferentiated Carcinoma
  • Extrahepatic Bile Duct Carcinoma
  • Extramammary Paget Disease
  • Fallopian Tube Adenocarcinoma
  • Fallopian Tube Transitional Cell Carcinoma
  • Fibromyxoid Tumor
  • Gallbladder Carcinoma
  • Gastric Neuroendocrine Carcinoma
  • Gastric Squamous Cell Carcinoma
  • Gastric Undifferentiated Carcinoma
  • Gastrointestinal Stromal Tumor
  • Gestational Trophoblastic Tumor
  • Giant Cell Carcinoma
  • Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type
  • Intestinal Neuroendocrine Carcinoma
  • Intrahepatic Cholangiocarcinoma
  • Lung Neuroendocrine Tumor
  • Lung Sarcomatoid Carcinoma
  • Major Salivary Gland Carcinoma
  • Malignant Neoplasm of Unknown Primary
  • Malignant Odontogenic Neoplasm
  • Malignant Peripheral Nerve Sheath Tumor
  • Malignant Solid Neoplasm
  • Malignant Testicular Sex Cord-Stromal Tumor
  • Metastatic Pituitary Neuroendocrine Tumor
  • Minimally Invasive Lung Adenocarcinoma
  • Mixed Mesodermal (Mullerian) Tumor
  • Mucinous Adenocarcinoma
  • Mucinous Cystadenocarcinoma
  • Nasal Cavity Adenocarcinoma
  • Nasal Cavity Carcinoma
  • Nasopharyngeal Carcinoma
  • Nasopharyngeal Low Grade Papillary Adenocarcinoma
  • Nasopharyngeal Undifferentiated Carcinoma
  • Oral Cavity Carcinoma
  • Oropharyngeal Undifferentiated Carcinoma
  • Ovarian Adenocarcinoma
  • Ovarian Germ Cell Tumor
  • Ovarian Mucinous Adenocarcinoma
  • Ovarian Squamous Cell Carcinoma
  • Ovarian Transitional Cell Carcinoma
  • Pancreatic Acinar Cell Carcinoma
  • Pancreatic Neuroendocrine Carcinoma
  • Paraganglioma
  • Paranasal Sinus Adenocarcinoma
  • Paranasal Sinus Carcinoma
  • Parathyroid Gland Carcinoma
  • PEComa
  • Penile Squamous Cell Carcinoma
  • Peritoneal Mesothelial Neoplasm
  • Placental Choriocarcinoma
  • Primary Peritoneal High Grade Serous Adenocarcinoma
  • Pseudomyxoma Peritonei
  • Rare Disorder
  • Scrotal Squamous Cell Carcinoma
  • Seminal Vesicle Adenocarcinoma
  • Seminoma
  • Serous Cystadenocarcinoma
  • Small Intestinal Adenocarcinoma
  • Small Intestinal Squamous Cell Carcinoma
  • Spindle Cell Neoplasm
  • Teratoma With Somatic-Type Malignancy
  • Testicular Non-Seminomatous Germ Cell Tumor
  • Thyroid Gland Carcinoma
  • Tracheal Carcinoma
  • Transitional Cell Carcinoma
  • Ureter Adenocarcinoma
  • Ureter Squamous Cell Carcinoma
  • Urethral Adenocarcinoma
  • Urethral Squamous Cell Carcinoma
  • Vaginal Adenocarcinoma
  • Vaginal Squamous Cell Carcinoma, Not Otherwise Specified
  • Vulvar Carcinoma
Interventions
  • PROCEDURE
  • BIOLOGICAL
No Results Yet
NCT02600949 | ENROLLING_BY_INVITATION | PHASE1
300 participants

Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2016-05-11
Completion:
2027-05-31
Conditions
  • Metastatic Colorectal Adenocarcinoma
  • Metastatic Pancreatic Ductal Adenocarcinoma
  • Stage IV Colorectal Cancer AJCC v7
  • Stage IV Pancreatic Cancer AJCC v6 and v7
  • Stage IVA Colorectal Cancer AJCC v7
  • Stage IVB Colorectal Cancer AJCC v7
Interventions
  • DRUG
  • BIOLOGICAL
  • PROCEDURE
No Results Yet
NCT02498613 | ACTIVE_NOT_RECRUITING | PHASE2
122 participants

A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2016-08-31
Completion:
2022-06-22
Conditions
  • Advanced Malignant Solid Neoplasm
  • Metastatic Lung Non-Small Cell Carcinoma
  • Metastatic Lung Small Cell Carcinoma
  • Metastatic Pancreatic Adenocarcinoma
  • Metastatic Triple-Negative Breast Carcinoma
  • Pancreatic Ductal Adenocarcinoma
  • Stage III Breast Cancer AJCC v7
  • Stage III Lung Non-Small Cell Cancer AJCC v7
  • Stage III Lung Small Cell Carcinoma AJCC v7
  • Stage III Pancreatic Cancer AJCC v6 and v7
  • Stage IIIA Breast Cancer AJCC v7
  • Stage IIIA Lung Non-Small Cell Cancer AJCC v7
  • Stage IIIA Lung Small Cell Carcinoma AJCC v7
  • Stage IIIB Breast Cancer AJCC v7
  • Stage IIIB Lung Non-Small Cell Cancer AJCC v7
  • Stage IIIB Lung Small Cell Carcinoma AJCC v7
  • Stage IIIC Breast Cancer AJCC v7
  • Stage IV Breast Cancer AJCC v6 and v7
  • Stage IV Lung Non-Small Cell Cancer AJCC v7
  • Stage IV Lung Small Cell Carcinoma AJCC v7
  • Stage IV Pancreatic Cancer AJCC v6 and v7
  • Triple-Negative Breast Carcinoma
  • Unresectable Lung Small Cell Carcinoma
  • Unresectable Pancreatic Adenocarcinoma
  • Unresectable Pancreatic Carcinoma
  • Unresectable Triple-Negative Breast Carcinoma
Interventions
  • OTHER
  • DRUG
  • PROCEDURE
Results Available
NCT02180867 | COMPLETED | PHASE2/PHASE3
140 participants

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2014-08-12
Completion:
2019-06-30
Conditions
  • Alveolar Soft Part Sarcoma
  • Angiomatoid Fibrous Histiocytoma
  • Atypical Fibroxanthoma
  • Clear Cell Sarcoma of Soft Tissue
  • Epithelioid Malignant Peripheral Nerve Sheath Tumor
  • Epithelioid Sarcoma
  • Extraskeletal Myxoid Chondrosarcoma
  • Extraskeletal Osteosarcoma
  • Fibrohistiocytic Neoplasm
  • Fibrosarcoma
  • Inflammatory Myofibroblastic Tumor
  • Intimal Sarcoma
  • Leiomyosarcoma
  • Liposarcoma
  • Liver Embryonal Sarcoma
  • Low Grade Fibromyxoid Sarcoma
  • Low Grade Myofibroblastic Sarcoma
  • Malignant Peripheral Nerve Sheath Tumor
  • Malignant Skin Granular Cell Tumor
  • Malignant Triton Tumor
  • Mesenchymal Chondrosarcoma
  • Myxofibrosarcoma
  • Myxoid Chondrosarcoma
  • Myxoinflammatory Fibroblastic Sarcoma
  • Nerve Sheath Neoplasm
  • PEComa
  • Pericytic Neoplasm
  • Plexiform Fibrohistiocytic Tumor
  • Sclerosing Epithelioid Fibrosarcoma
  • Skin Glomus Tumor
  • Stage IB Soft Tissue Sarcoma AJCC v7
  • Stage IIB Soft Tissue Sarcoma AJCC v7
  • Stage III Soft Tissue Sarcoma AJCC v7
  • Stage IV Soft Tissue Sarcoma AJCC v7
  • Synovial Sarcoma
  • Undifferentiated High Grade Pleomorphic Sarcoma of Bone
Interventions
  • DRUG
  • RADIATION
  • PROCEDURE
Results Available
NCT01867840 | COMPLETED
20 participants

Role of ASICs in Human Inflammatory Pain

Study Type:
OBSERVATIONAL
Last Updated:
2026-06-17
Start Date:
2018-01-01
Completion:
2022-11-30
Conditions
  • Arthritis
  • Osteoarthritis
  • Chondrocalcinosis
  • Gouty Arthritis
  • Rheumatoid Arthritis
No Results Yet
NCT01841723 | ACTIVE_NOT_RECRUITING | PHASE2
44 participants

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2013-04-30
Completion:
2029-12-31
Conditions
  • Hairy Cell Leukemia
  • Hairy Cell Leukemia Variant
  • Recurrent Hairy Cell Leukemia
  • Recurrent Hairy Cell Leukemia Variant
Interventions
  • PROCEDURE
  • DRUG
No Results Yet
NCT01652092 | ACTIVE_NOT_RECRUITING | NA
57 participants

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

Study Type:
INTERVENTIONAL
Last Updated:
2026-06-17
Start Date:
2012-09-04
Completion:
2025-12-30
Conditions
  • SCID
  • Omenn's Syndrome
  • Reticular Dysgenesis
  • Wiskott-Aldrich Syndrome
  • Bare Lymphocyte Syndrome
  • Common Variable Immunodeficiency
  • Chronic Granulomatous Disease
  • CD40 Ligand Deficiency
  • Hyper IgM Syndrome
  • X-linked Lymphoproliferative Disease
  • Hemophagocytic Lymphohistiocytosis
  • Griscelli Syndrome
  • Chediak-Higashi Syndrome
  • Langerhan's Cell Histiocytosis
Interventions
  • DRUG
  • BIOLOGICAL
No Results Yet
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