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Clinical Trials

Showing trials with last updates posted in 2026.

NCT04284774 | ACTIVE_NOT_RECRUITING | PHASE2
5 participants

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-27
Start Date:
2020-10-13
Completion:
2024-03-31
Conditions
  • Malignant Solid Neoplasm
  • Recurrent Adrenal Gland Pheochromocytoma
  • Recurrent Ectomesenchymoma
  • Recurrent Ependymoma
  • Recurrent Ewing Sarcoma
  • Recurrent Hepatoblastoma
  • Recurrent Kidney Wilms Tumor
  • Recurrent Langerhans Cell Histiocytosis
  • Recurrent Malignant Germ Cell Tumor
  • Recurrent Malignant Glioma
  • Recurrent Medulloblastoma
  • Recurrent Melanoma
  • Recurrent Neuroblastoma
  • Recurrent Non-Hodgkin Lymphoma
  • Recurrent Osteosarcoma
  • Recurrent Peripheral Primitive Neuroectodermal Tumor
  • Recurrent Rhabdoid Tumor
  • Recurrent Rhabdoid Tumor of the Kidney
  • Recurrent Rhabdomyosarcoma
  • Recurrent Soft Tissue Sarcoma
  • Recurrent Thyroid Gland Carcinoma
  • Recurrent WHO Grade 2 Glioma
  • Refractory Adrenal Gland Pheochromocytoma
  • Refractory Ependymoma
  • Refractory Ewing Sarcoma
  • Refractory Hepatoblastoma
  • Refractory Langerhans Cell Histiocytosis
  • Refractory Malignant Germ Cell Tumor
  • Refractory Malignant Glioma
  • Refractory Medulloblastoma
  • Refractory Melanoma
  • Refractory Neuroblastoma
  • Refractory Non-Hodgkin Lymphoma
  • Refractory Osteosarcoma
  • Refractory Peripheral Primitive Neuroectodermal Tumor
  • Refractory Rhabdoid Tumor
  • Refractory Rhabdoid Tumor of the Kidney
  • Refractory Rhabdomyosarcoma
  • Refractory Soft Tissue Sarcoma
  • Refractory Thyroid Gland Carcinoma
  • Refractory WHO Grade 2 Glioma
Interventions
  • DRUG
Results Available
NCT04267848 | RECRUITING | PHASE3
1210 participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-27
Start Date:
2020-06-16
Completion:
2027-01-31
Conditions
  • Lung Non-Small Cell Carcinoma
  • Lung Non-Small Cell Squamous Carcinoma
  • Lung Non-Squamous Non-Small Cell Carcinoma
  • Stage II Lung Cancer AJCC v8
  • Stage IIIA Lung Cancer AJCC v8
  • Stage IIIB Lung Cancer AJCC v8
Interventions
  • PROCEDURE
  • DRUG
  • OTHER
  • BIOLOGICAL
No Results Yet
NCT04183218 | COMPLETED
24 participants

Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes

Study Type:
OBSERVATIONAL
Last Updated:
2026-05-27
Start Date:
2019-09-23
Completion:
2024-01-06
Conditions
  • Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8
  • Clinical Stage I Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8
  • Clinical Stage II Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8
  • Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage III Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8
  • Localized Esophageal Carcinoma
  • Localized Lung Carcinoma
  • Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage I Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage I Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IA Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IA Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IB Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage II Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage II Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IIA Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IIB Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage III Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8
  • Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8
  • Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage I Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage II Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8
  • Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8
  • Stage 0 Lung Cancer AJCC v8
  • Stage I Lung Cancer AJCC v8
  • Stage IA1 Lung Cancer AJCC v8
  • Stage IA2 Lung Cancer AJCC v8
  • Stage IA3 Lung Cancer AJCC v8
  • Stage IB Lung Cancer AJCC v8
  • Stage II Lung Cancer AJCC v8
  • Stage IIA Lung Cancer AJCC v8
  • Stage IIB Lung Cancer AJCC v8
  • Stage III Lung Cancer AJCC v8
  • Stage IIIA Lung Cancer AJCC v8
  • Stage IIIB Lung Cancer AJCC v8
  • Stage IIIC Lung Cancer AJCC v8
Interventions
  • PROCEDURE
  • DEVICE
  • OTHER
  • RADIATION
Results Available
NCT03919071 | ACTIVE_NOT_RECRUITING | PHASE2
58 participants

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-27
Start Date:
2020-02-20
Completion:
2027-09-30
Conditions
  • Anaplastic Astrocytoma
  • Anaplastic Astrocytoma, Not Otherwise Specified
  • Anaplastic Ganglioglioma
  • Anaplastic Pleomorphic Xanthoastrocytoma
  • Glioblastoma
  • Malignant Glioma
  • WHO Grade 3 Glioma
  • WHO Grade 4 Glioma
Interventions
  • PROCEDURE
  • DRUG
  • RADIATION
No Results Yet
NCT03899155 | RECRUITING | PHASE2
1500 participants

Pan Tumor Rollover Study

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-27
Start Date:
2019-08-09
Completion:
2029-08-25
Conditions
  • Cancer
Interventions
  • DRUG
No Results Yet
NCT03747627 | COMPLETED
475 participants

BPF Genetics of ILD Study

Study Type:
OBSERVATIONAL
Last Updated:
2026-05-27
Start Date:
2019-01-19
Completion:
2025-01-19
Conditions
  • Lung; Disease, Interstitial, With Fibrosis
  • Alveolitis, Extrinsic Allergic
  • Bird Fancier's Lung
  • Idiopathic Interstitial Pneumonias
  • Lung Diseases, Interstitial
  • Idiopathic Pulmonary Fibrosis
Interventions
  • DIAGNOSTIC_TEST
No Results Yet
NCT03698994 | ACTIVE_NOT_RECRUITING | PHASE2
20 participants

Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

Study Type:
INTERVENTIONAL
Last Updated:
2026-05-27
Start Date:
2018-11-14
Completion:
2022-03-31
Conditions
  • Advanced Malignant Solid Neoplasm
  • Recurrent Ependymal Tumor
  • Recurrent Ewing Sarcoma
  • Recurrent Glioma
  • Recurrent Hepatoblastoma
  • Recurrent Histiocytic and Dendritic Cell Neoplasm
  • Recurrent Langerhans Cell Histiocytosis
  • Recurrent Malignant Germ Cell Tumor
  • Recurrent Malignant Solid Neoplasm
  • Recurrent Medulloblastoma
  • Recurrent Neuroblastoma
  • Recurrent Non-Hodgkin Lymphoma
  • Recurrent Osteosarcoma
  • Recurrent Peripheral Primitive Neuroectodermal Tumor
  • Recurrent Primary Malignant Central Nervous System Neoplasm
  • Recurrent Rhabdoid Tumor
  • Recurrent Rhabdomyosarcoma
  • Recurrent Soft Tissue Sarcoma
  • Refractory Ependymoma
  • Refractory Ewing Sarcoma
  • Refractory Glioma
  • Refractory Hepatoblastoma
  • Refractory Histiocytic and Dendritic Cell Neoplasm
  • Refractory Langerhans Cell Histiocytosis
  • Refractory Malignant Germ Cell Tumor
  • Refractory Malignant Solid Neoplasm
  • Refractory Medulloblastoma
  • Refractory Neuroblastoma
  • Refractory Non-Hodgkin Lymphoma
  • Refractory Osteosarcoma
  • Refractory Peripheral Primitive Neuroectodermal Tumor
  • Refractory Primary Malignant Central Nervous System Neoplasm
  • Refractory Rhabdoid Tumor
  • Refractory Rhabdomyosarcoma
  • Refractory Soft Tissue Sarcoma
  • Wilms Tumor
Interventions
  • OTHER
  • DRUG
Results Available
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