Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers

Summary

The purpose of this study is to compare two approaches for monitoring pancreatic cysts as well as to identify associated biomarkers. The study doctors want to compare more frequent monitoring versus less frequent monitoring as well as identify biomarkers which may improve risk detection of transformation to pancreatic cancer. The study doctors want to learn which monitoring method and which biomarkers lead to better outcomes for patients.

Conditions

• Pancreatic Neoplasm

Interventions

PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT

PROCEDURE

Endoscopic Ultrasound

Undergo EUS

PROCEDURE

Endoscopic Ultrasound-Guided Fine-Needle Aspiration

Undergo EUS-FNA

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

OTHER

Quality-of-Life Assessment

Ancillary studies (PRIOR TO ADDENDUM #5 08/13/2024)

OTHER

Questionnaire Administration

Ancillary studies (PRIOR TO ADDENDUM #5 08/13/2024)

PROCEDURE

Surgical Procedure

Undergo surgery

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• ECOG-ACRIN Cancer Research Group

  lead NETWORK

Principal Investigators

• David S Weinberg · ECOG-ACRIN Cancer Research Group

Eligibility

Min Age

50 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-06-16

Primary Completion

2030-12-31

Completion

2031-12-31

Countries

• United States
• Canada
• Puerto Rico
• South Korea

Study Locations