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BPF Genetics of ILD Study

NCT03747627 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 475

Last updated 2025-04-25

No results posted yet for this study

Summary

The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group.

We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.

Conditions

  • Lung; Disease, Interstitial, With Fibrosis
  • Alveolitis, Extrinsic Allergic
  • Bird Fancier's Lung
  • Idiopathic Interstitial Pneumonias
  • Lung Diseases, Interstitial
  • Idiopathic Pulmonary Fibrosis

Interventions

DIAGNOSTIC_TEST

Genetic profiling

All participating subjects will undergo detailed genetic analysis, with the aim of detecting novel genetic drivers for the development of interstitial lung disease in the context of known sensitising agent (pigeon antigen)

Sponsors & Collaborators

  • University of Leicester

    collaborator OTHER

  • University of Glasgow

    collaborator OTHER

  • Newcastle University

    collaborator OTHER

  • British Lung Foundation

    collaborator OTHER

  • British Pigeon Fanciers Medical Research

    collaborator UNKNOWN

  • University of Dundee

    lead OTHER

Principal Investigators

  • Mark Spears, PhD, FRCP · NHS Tayside & University of Dundee

  • Louise Wain, PhD · University of Leicester

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-01-19
Primary Completion
2025-01-19
Completion
2028-01-01

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03747627 on ClinicalTrials.gov