Clinical Trials Updated in 2025

NCT05209984 | WITHDRAWN | PHASE3

0 participants

A Phase 3, Double-blind/Double-dummy, Safety/Efficacy/Superiority of Sibutramine/Topiramate XR in Adults With Overweight

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2026-04-30
Completion:: 2028-03-31

Conditions

Overweight
Obesity

Interventions

DRUG

No Results Yet

NCT05192122 | RECRUITING | PHASE1

50 participants

Free From Maintenance Drug Therapy in Multiple Myeloma (The FREEDMM Trial) for Minimal Residual Disease (MRD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-12-31
Completion:: 2029-01-31

Conditions

Multiple Myeloma

Interventions

OTHER

No Results Yet

NCT05187650 | RECRUITING | NA

34 participants

Effectiveness of a Powered Exoskeleton Combined With FES for Patients With Chronic SCI: a RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-03-18
Completion:: 2027-12-31

Conditions

Spinal Cord Injuries
Gait Disorders, Neurologic

Interventions

DEVICE

No Results Yet

NCT05183204 | SUSPENDED | PHASE2

33 participants

Paxalisib With a High Fat, Low Carb Diet and Metformin for Glioblastoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-02-14
Completion:: 2026-06-30

Conditions

Glioblastoma

Interventions

DRUG
OTHER

No Results Yet

NCT05171166 | TERMINATED | PHASE2/PHASE3

18 participants

Neoadjuvant HAIC of TACE Plus Donafenib in BCLC B Stage HCC: a Multi-center Randomized Controlled Trial.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-12-24
Completion:: 2025-10-31

Conditions

Hepatocellular Carcinoma

Interventions

PROCEDURE
DRUG

No Results Yet

NCT05152134 | COMPLETED | PHASE3

234 participants

Mobile & Online-Based Interventions to Lessen Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2023-08-23
Completion:: 2025-08-15

Conditions

Chronic Pain
Opioid Misuse
Opioid Use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT05145946 | WITHDRAWN | NA

0 participants

Tracking Biomarkers of Speech Intelligibility

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-01-31
Completion:: 2022-12-31

Conditions

High-Frequency Hearing Loss

Interventions

BEHAVIORAL

No Results Yet

NCT05145075 | ACTIVE_NOT_RECRUITING | NA

200 participants

Surveying the Receptivity for Telemedicine Pre-operative Consultation in UZ Brussel.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2023-03-15
Completion:: 2023-08-31

Conditions

Remote Consultation

Interventions

OTHER

No Results Yet

NCT05134779 | RECRUITING

400 participants

De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-01-12
Completion:: 2027-12-31

Conditions

Breast Cancer

Interventions

PROCEDURE

No Results Yet

NCT05127187 | COMPLETED | NA

350 participants

Estimation of the Prevalence of HIV, Hepatitis C and Hepatitis B Infection Among Detainees in the Nîmes Administrative Detention Center

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-02-08
Completion:: 2022-12-07

Conditions

HIV Infections
Hepatitis C
Hepatitis B

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05120752 | RECRUITING | PHASE3

60 participants

Efficacy of a Low FODMAP Diet in the Absence of Lactose Malabsorption in Moderate to Severe ROME IV IBS.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-11-02
Completion:: 2028-01-31

Conditions

Irritable Bowel Syndrome

Interventions

OTHER

No Results Yet

NCT05096091 | COMPLETED

5399 participants

International Study on COVID-19 Vaccine to Assess Immunogenicity, Reactogenicity and Efficacy (InVITE)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-08-16
Completion:: 2025-08-19

Conditions

COVID-19

No Results Yet

NCT05044676 | TERMINATED

4 participants

Immune Cells as a New Biomarker of Response in Patients Treated by Immunotherapy for Advanced Hepatocellular Carcinoma

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2023-09-08
Completion:: 2025-09-22

Conditions

Hepatocellular Carcinoma

Interventions

OTHER

No Results Yet

NCT05030506 | ACTIVE_NOT_RECRUITING | PHASE1

45 participants

A Study of Belzutifan (MK-6482) as Monotherapy and in Combination With Lenvatinib (E7080/MK-7902) With or Without Pembrolizumab (MK-3475) in China Participants With Advanced Renal Cell Carcinoma (MK-6482-010)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-10-13
Completion:: 2027-06-30

Conditions

Renal Cell Carcinoma

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT05026528 | TERMINATED | NA

138 participants

Digital Diabetes Self Management Education and Support for Patients With Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-11-30
Completion:: 2025-04-30

Conditions

Type 2 Diabetes

Interventions

OTHER

No Results Yet

NCT05024513 | COMPLETED | PHASE2

127 participants

Biliary Drainage Plus HAIC in Locally Advanced pCCA

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-11-01
Completion:: 2025-10-20

Conditions

Perihilar Cholangiocarcinoma

Interventions

DRUG
PROCEDURE
OTHER

No Results Yet

NCT05007730 | COMPLETED | NA

10 participants

Enhancing Health and Quality of Life for Individuals With Dementia Through Transitional-State Snacks

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-06-01
Completion:: 2025-11-03

Conditions

Dementia
Nutrition Poor

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04992611 | COMPLETED | NA

190 participants

Sleep Timing, Eating and Activity Measurement Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-07-16
Completion:: 2025-07-26

Conditions

Sleep
Circadian Rhythm Disorders
Dietary Habits

Interventions

BEHAVIORAL

No Results Yet

NCT04974593 | RECRUITING | PHASE3

90 participants

Predictive Value of Hydrogen/Methane Lactose Breath Testing on the Therapeutic Effect of Lactose-free Diet in Moderate to Severe ROME IV IBS.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-10-22
Completion:: 2028-01-01

Conditions

Irritable Bowel Syndrome
Lactose Intolerant

Interventions

OTHER

No Results Yet

NCT04966663 | RECRUITING | PHASE2

66 participants

Using ctDNA to Determine Therapies for Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-03-28
Completion:: 2026-08-01

Conditions

Non Small Cell Lung Cancer
Complete Surgical Resection
Circulating Tumor DNA

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04965090 | COMPLETED | PHASE2

43 participants

A Study of Amivantamab and Lazertinib in People With Non-Small Cell Lung Cancer (NSCLC)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-09-30
Completion:: 2025-12-15

Conditions

Metastatic Non Small Cell Lung Cancer
Recurrent Non Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT04950101 | COMPLETED | NA

304 participants

Prevalence of Anal High-risk Human Papilloma Virus Infection and Abnormal Anal Cytology in Men Who Have Sex With Men Using Pre Exposure Prophylaxis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-10-20
Completion:: 2023-05-04

Conditions

Human Papilloma Virus

Interventions

OTHER

No Results Yet

NCT04939402 | ACTIVE_NOT_RECRUITING | NA

200 participants

SARS-COV-2 Seroprevalence and Seroconversion Among Employees of the UZ Brussel Following COVID-19 Vaccination Using an Adenoviral Vector

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-05-05
Completion:: 2028-05-31

Conditions

SARS-CoV-2
Covid19

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04927377 | COMPLETED | NA

90 participants

Accessible and Inclusive Diabetes Telecoaching Self-Management Program

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-10-31
Completion:: 2025-09-30

Conditions

Diabete Type 2
Disability Physical

Interventions

BEHAVIORAL

No Results Yet

NCT04922411 | COMPLETED | NA

49 participants

Cortical Network Modulation by Subthalamic Nucleus DBS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-04-23
Completion:: 2025-04-01

Conditions

Parkinson Disease
Deep Brain Stimulation

Interventions

DEVICE

No Results Yet

NCT04913493 | TERMINATED | NA

22 participants

Use of Sublingual Microcirculation and FloTrac Monitoring During Major Vascular Surgery and Its Effect on Hospital LOS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-06-08
Completion:: 2023-04-01

Conditions

Carotid Artery Plaque
Aortic Aneurysm
Aneurysm

Interventions

PROCEDURE

No Results Yet

NCT04899102 | RECRUITING | NA

25 participants

Intermittent Fasting for NAFLD in Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2022-02-01
Completion:: 2026-07-31

Conditions

Fatty Liver
Intermittent Fasting
Fatty Liver, Nonalcoholic
Non-Alcoholic Fatty Liver Disease
Liver Fat

Interventions

BEHAVIORAL

No Results Yet

NCT04868058 | TERMINATED | NA

28 participants

Serratus Anterior or Erector Spinae Block for Hybrid Arrhythmia Ablation Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-10-02
Completion:: 2021-05-11

Conditions

Arrhythmia

Interventions

DRUG

No Results Yet

NCT04863924 | ACTIVE_NOT_RECRUITING

170 participants

Accelerating Lung Cancer Diagnosis Through Liquid Biopsy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-01-14
Completion:: 2023-07-25

Conditions

Non-small Cell Lung Cancer

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04815005 | RECRUITING

1000 participants

HoFH, the International Clinical Collaborators Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2017-01-24
Completion:: 2026-12-31

Conditions

Homozygous Familial Hypercholesterolemia

Interventions

OTHER

No Results Yet

NCT04813328 | ACTIVE_NOT_RECRUITING

1500 participants

The Effect of Helminth Infection Plus COVID-19 Infection on the Immune Response and Intestinal Microorganisms

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-06-01
Completion:: 2026-04-30

Conditions

COVID-19

No Results Yet

NCT04756791 | WITHDRAWN | PHASE4

0 participants

Prospective Comparison of Single-Injection Serratus Anterior Plane Block With Ropivacaine Versus Local Infiltration of Anaesthetic After Breast Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-06-16
Completion:: 2023-12-31

Conditions

Mastectomy; Lymphedema

Interventions

PROCEDURE

No Results Yet

NCT04747587 | COMPLETED | NA

53 participants

Non-use After Stroke: Influence of Applied Force and Precision When Reaching With the Paretic Upper Limb

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-05-11
Completion:: 2023-04-25

Conditions

Stroke

Interventions

OTHER

No Results Yet

NCT04740736 | COMPLETED | NA

106 participants

Cardiovascular Analysis of PEM

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-08-31
Completion:: 2025-07-11

Conditions

Myalgic Encephalomyelitis
Chronic Fatigue Syndrome

Interventions

PROCEDURE

No Results Yet

NCT04729504 | RECRUITING | NA

2000 participants

Cultural Adaptation of a SSI for Youth Anxiety

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-03-08
Completion:: 2026-12-21

Conditions

Anxiety Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT04697368 | ACTIVE_NOT_RECRUITING | NA

70 participants

The Efficacy of Upper Limb Rehabilitation With Exoskeleton in Patients With Subacute Stroke.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-12-28
Completion:: 2025-03-01

Conditions

Stroke
Upper Extremity Paresis

Interventions

DEVICE
OTHER

No Results Yet

NCT04693520 | COMPLETED | PHASE2

84 participants

Biomarker Effects of ALZ-801 in APOE4 Carriers With Early Alzheimer's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-09-30
Completion:: 2023-06-20

Conditions

Early Alzheimer's Disease

Interventions

DRUG

No Results Yet

NCT04686136 | COMPLETED | PHASE3

596 participants

A Long-Term Safety and Tolerability Extension Study Evaluating Atogepant for the Prevention of Chronic or Episodic Migraine

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-02-19
Completion:: 2025-10-20

Conditions

Episodic Migraine
Chronic Migraine

Interventions

DRUG

No Results Yet

NCT04657588 | COMPLETED | NA

73 participants

Controlling Faecal Incontinence With a Novel Anal Device: a Cost-effectiveness Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-06-06
Completion:: 2024-08-01

Conditions

Faecal Incontinence

Interventions

DEVICE
OTHER

No Results Yet

NCT04627766 | RECRUITING | NA

48 participants

Validation of Continuous Monitoring of Vital Signs in Children With a Connected Patch

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2025-02-02
Completion:: 2026-10-01

Conditions

Vital Signs

Interventions

DEVICE

No Results Yet