Clinical Trials Updated in 2025

NCT04618692 | COMPLETED | NA

52 participants

Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-12-02
Completion:: 2023-03-30

Conditions

Liver Failure
Liver Diseases
Liver Cancer
Liver Neoplasms
Liver Dysfunction

Interventions

OTHER

No Results Yet

NCT04603820 | ACTIVE_NOT_RECRUITING

866 participants

Registry Study of Pregnancy and Breast Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-11-18
Completion:: 2030-01-31

Conditions

Breast Cancer and Pregnancy

No Results Yet

NCT04566185 | COMPLETED | NA

14 participants

Evaluation of the Predictive Value of 18F-fluorodeoxyglucose Positron Emission Tomography and Brain Perfusion Computed Tomography for the Efficacy of Anti-angiogenic Therapy (Bevacizumab) in Recurrent Glioblastoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-12-16
Completion:: 2023-06-27

Conditions

Glioblastoma

Interventions

OTHER

No Results Yet

NCT04550728 | RECRUITING | PHASE1/PHASE2

60 participants

Hybrid Robot+FES Stroke Rehabilitation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-08-01
Completion:: 2026-10-01

Conditions

Stroke

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT04548661 | COMPLETED | NA

2701 participants

Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2023-08-02
Completion:: 2025-09-30

Conditions

Surgical Site Infection

Interventions

PROCEDURE

No Results Yet

NCT04543201 | RECRUITING | NA

50 participants

Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-10-08
Completion:: 2026-07-31

Conditions

Glioma

Interventions

BEHAVIORAL

No Results Yet

NCT04541082 | RECRUITING | PHASE1

102 participants

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-10-26
Completion:: 2026-07-31

Conditions

Central Nervous System Neoplasms
Glioblastoma
Gliosarcoma, Adult
Anaplastic Oligodendroglioma
Anaplastic Astrocytoma
Pilocytic Astrocytoma
Oligodendroglioma
Gliomatosis Cerebri
Pleomorphic Xanthoastrocytoma
Anaplastic Pleomorphic Xanthoastrocytoma
Diffuse Midline Glioma, H3 K27M-Mutant
Ependymoma
Ependymoma, Anaplastic
Medulloblastoma
Teratoid Rhabdoid Tumor
Neuroectodermal Tumors, Primitive
Neuroectodermal Tumors
Anaplastic Meningioma
Atypical Meningioma
Choroid Plexus Neoplasms
Pineal Tumor
Diffuse Astrocytoma
Glial Tumor

Interventions

DRUG

No Results Yet

NCT04529070 | TERMINATED | NA

68 participants

Nightmare Rescripting and Rehearsal

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-01-21
Completion:: 2025-12-09

Conditions

Nightmare
Sleep

Interventions

BEHAVIORAL

No Results Yet

NCT04496960 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

23 participants

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren's Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-05-18
Completion:: 2025-01-14

Conditions

Sjogren's Syndrome

Interventions

DRUG
OTHER

Results Available

NCT04489433 | NO_LONGER_AVAILABLE

Compassionate Use Program to Access Trametinib and Dabrafenib for Patients With BRAF Mutation-positive Metastatic Melanoma

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-12-18

Conditions

Melanoma

Interventions

DRUG

No Results Yet

NCT04458402 | COMPLETED | NA

8 participants

Adjuvant Hypofractionated Whole Pelvis Radiation Therapy in Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-02-04
Completion:: 2025-01-30

Conditions

Endometrial Cancer

Interventions

RADIATION

No Results Yet

NCT04446117 | ACTIVE_NOT_RECRUITING | PHASE3

575 participants

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-10-19
Completion:: 2024-04-19

Conditions

Metastatic Prostate Cancer
Prostate Adenocarcinoma

Interventions

DRUG

Results Available

NCT04431700 | TERMINATED | NA

28 participants

Study of Dietary Composition in Crohn's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-10-05
Completion:: 2025-03-31

Conditions

Inflammatory Bowel Diseases
Crohn Disease

Interventions

OTHER

No Results Yet

NCT04400357 | COMPLETED | NA

268 participants

Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-09-28
Completion:: 2024-11-28

Conditions

Pancreatic Adenocarcinoma
Pancreatic Cysts
Pancreatic Endocrine Tumors
Chronic Pancreatitis
Cholangiocarcinoma, Extrahepatic
Ampullary Adenocarcinoma
Duodenal Adenocarcinoma

Interventions

PROCEDURE

No Results Yet

NCT04395495 | RECRUITING

1000 participants

RASopathy Biorepository

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2017-06-27
Completion:: 2065-12-31

Conditions

RAS Mutation
Neurofibromatosis 1
Noonan Syndrome
Noonan Syndrome With Multiple Lentigines
Noonan Neurofibromatosis Syndrome
Cardiofaciocutaneous Syndrome
Costello Syndrome
Legius Syndrome
Smith-Kingsmore Syndrome
MTOR Gene Mutation
GATOR-1 Gene Mutation
SYNGAP1-Related Intellectual Disability
DLG4
MAPK1 Gene Mutation

No Results Yet

NCT04382963 | COMPLETED | NA

120 participants

Stroke Prevention in the Wisconsin Native American Population

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-04-14
Completion:: 2025-10-01

Conditions

Stroke
Atherosclerosis

Interventions

OTHER

No Results Yet

NCT04332068 | COMPLETED | PHASE2

240 participants

Ivermectin Safety in Small Children

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2023-11-18
Completion:: 2025-04-04

Conditions

Scabies

Interventions

DRUG
OTHER

No Results Yet

NCT04269590 | COMPLETED | NA

80 participants

Triggering Motor Memory Consolidation in PD: Complex Practice of Fine Motor Tasks and Brain Activity During Learning

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-05-03
Completion:: 2023-05-16

Conditions

Parkinson Disease

Interventions

BEHAVIORAL

No Results Yet

NCT04210336 | COMPLETED | NA

200 participants

Clinical Trial to Evaluate Papilocare® Gel Efficacy Into Repairment of Cervical Lesions Caused by HPV

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2018-08-07
Completion:: 2022-11-30

Conditions

HPV Infection
Lesion Cervix

Interventions

DEVICE

No Results Yet

NCT04209946 | COMPLETED | NA

180 participants

Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-01-22
Completion:: 2023-05-08

Conditions

Premature Lungs
Respiratory Distress Syndrome
Surfactant Deficiency Syndrome Neonatal

Interventions

PROCEDURE

No Results Yet

NCT04146376 | RECRUITING

110 participants

Von Willebrand Factor in Pregnancy (VIP) Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-10-12
Completion:: 2026-12-31

Conditions

Von Willebrand Diseases

Interventions

OTHER
DRUG

No Results Yet

NCT04113863 | TERMINATED | PHASE2

76 participants

Evaluation of ATRA Activity in Combination With Anastrozole in Pre-operative Phase of Operable Early Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-06-18
Completion:: 2025-01-30

Conditions

Breast Neoplasm Female

Interventions

DRUG

No Results Yet

NCT04100148 | ACTIVE_NOT_RECRUITING | NA

1686 participants

SyncAV Post-Market Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-10-03
Completion:: 2026-05-31

Conditions

Congestive Heart Failure

Interventions

DEVICE

No Results Yet

NCT04068909 | COMPLETED

1655 participants

ObseRvation After Acute Coronary Syndrome for deveLopment of trEatment Options

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2014-11-05
Completion:: 2018-02-20

Conditions

Acute Coronary Syndrome

No Results Yet

NCT04049084 | ENROLLING_BY_INVITATION

70 participants

An Observational LTFU Study for Patients Previously Treated With Autologous ex Vivo Gene Therapy for ADA-SCID

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-09-26
Completion:: 2040-08-31

Conditions

Adenosine Deaminase Deficiency
Severe Combined Immunodeficiency (SCID)

Interventions

BIOLOGICAL

No Results Yet

NCT04046536 | COMPLETED | NA

204 participants

rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-10-01
Completion:: 2025-06-30

Conditions

Gulf War Illness
Depression

Interventions

DEVICE

No Results Yet

NCT04037514 | COMPLETED | PHASE3

133 participants

Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2017-07-07
Completion:: 2024-12-18

Conditions

Patent Ductus Arteriosus After Premature Birth

Interventions

DRUG

No Results Yet

NCT04009109 | ACTIVE_NOT_RECRUITING | PHASE2

79 participants

Study of Lenalidomide/Ixazomib/Dexamethasone/Daratumumab in Transplant-Ineligible Patients With Newly Diagnosed MM

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-10-21
Completion:: 2026-12-31

Conditions

Myeloma, Multiple

Interventions

DRUG

No Results Yet

NCT04008056 | COMPLETED | NA

138 participants

Impact of Patient Reported Outcomes for Pre-chemotherapy Medical Decision in Day Patients With Digestive Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-11-16
Completion:: 2021-11-11

Conditions

Digestive Cancer

Interventions

OTHER

No Results Yet

NCT03979365 | COMPLETED | PHASE4

261 participants

Envarsus XR Compared to Immediate Release Tacrolimus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-07-18
Completion:: 2022-03-29

Conditions

Kidney Transplant Recipients

Interventions

DRUG

Results Available

NCT03945240 | TERMINATED | NA

80 participants

Evaluating Different Low-level Laser Therapies to Treat Neck Pain in Air Force Pilots and Flight Crew

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2020-10-01
Completion:: 2025-12-09

Conditions

Neck Pain

Interventions

PROCEDURE

No Results Yet

NCT03923374 | RECRUITING

600 participants

Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2018-09-15
Completion:: 2026-12-30

Conditions

Opioid-use Disorder
Opioid Use, Unspecified
Buprenorphine Dependence

Interventions

DRUG
DIAGNOSTIC_TEST

No Results Yet

NCT03892980 | ACTIVE_NOT_RECRUITING | NA

145 participants

Robotic-Assisted da Vinci System Prophylactic Nipple-Sparing Mastectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2021-03-26
Completion:: 2027-04-30

Conditions

Nipple Sparing Mastectomy

Interventions

DEVICE

No Results Yet

NCT03793335 | ENROLLING_BY_INVITATION

40000 participants

Individually Tailored Strategies for the Precision Prevention of Gastric Cancer and Colorectal Cancer in the Community

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-04-14
Completion:: 2025-12-31

Conditions

Gastric Cancer
Colorectal Cancer

No Results Yet

NCT03723616 | COMPLETED | NA

2588 participants

Reactions to Warnings on Hookah Ads

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2018-10-05
Completion:: 2021-03-26

Conditions

Reactions to Warnings
Hookah Smoking

Interventions

BEHAVIORAL

Results Available

NCT03654768 | ACTIVE_NOT_RECRUITING | PHASE2

81 participants

Testing the Addition of Ruxolitinib to the Usual Treatment (Tyrosine Kinase Inhibitors) for Chronic Myeloid Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2018-10-24
Completion:: 2024-07-01

Conditions

Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Interventions

DRUG
OTHER

Results Available

NCT03617263 | TERMINATED | PHASE2

60 participants

Saroglitazar Magnesium 4 mg in the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in Women With PCOS (EVIDENCES VII)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2019-02-12
Completion:: 2024-10-28

Conditions

Non-alcoholic Fatty Liver Disease in Women With PCOS

Interventions

DRUG

Results Available

NCT03608956 | WITHDRAWN

0 participants

Renal Oxygen Saturation and Its Association With Acute Renal Injury

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2018-05-01
Completion:: 2019-03-31

Conditions

Acute Kidney Injury
Children
Cardiac Surgery

No Results Yet

NCT03598829 | COMPLETED

219 participants

A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-18
Start Date:: 2018-07-01
Completion:: 2023-11-15

Conditions

Knee Osteoarthritis
Arthropathy of Knee
Arthrofibrosis

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT03573310 | COMPLETED | PHASE1

114 participants

A Study of JNJ-64619178, an Inhibitor of PRMT5 in Participants With Advanced Solid Tumors, NHL, and Lower Risk MDS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-18
Start Date:: 2018-07-13
Completion:: 2025-09-25

Conditions

Neoplasms
Solid Tumor, Adult
Non-Hodgkin Lymphoma
Myelodysplastic Syndromes

Interventions

DRUG

No Results Yet