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A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients

NCT03598829 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 219

Last updated 2025-12-18

No results posted yet for this study

Summary

This research is being done to see if the amount of an enzyme in blood (called serum mast cell tryptase) changes before and after surgery. The investigators would like to see if these amounts are related to knee stiffness and pain in subjects that undergo a total knee replacement.

Conditions

Interventions

DIAGNOSTIC_TEST

Tryptase, Serum test

Blood draw lab test which measures concentration of Tryptase in the sample. Tryptase is the one of the primary secretions of active mast cells and is used as a measure of inflammatory activity. Normal Reference Value: \<11.5 ng/mL

Sponsors & Collaborators

Principal Investigators

  • Matthew Abdel, M.D. · Mayo Clinic

Eligibility

Min Age
20 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2023-11-15
Completion
2023-11-15

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03598829 on ClinicalTrials.gov