Clinical Trials Updated in 2025

NCT05686798 | RECRUITING | PHASE1

18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-11-29
Completion:: 2027-01-31

Conditions

Malignant Glioma of Brain
Astrocytoma
Malignant Astrocytoma
Brain Tumor
Glioma
Brain Cancer
Glioblastoma
Glioblastoma Multiforme
GBM

Interventions

BIOLOGICAL

No Results Yet

NCT05673759 | TERMINATED

148 participants

Event-Related Potential (ERP) Components in Clinical Diagnosis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2023-03-06
Completion:: 2025-05-01

Conditions

Alzheimer Disease
Dementia, Mild
Mild Cognitive Impairment

Interventions

DEVICE
BEHAVIORAL

No Results Yet

NCT05660850 | COMPLETED | PHASE2

49 participants

A Study To Evaluate The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamic Effects Of GDC-6599 In Patients With Chronic Cough

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2023-03-22
Completion:: 2024-10-20

Conditions

Chronic Refractory Cough (CRC) With Non-atopic Asthma
CRC With Atopic Asthma
Unexplained Chronic Cough
CRC With Chronic Obstructive Pulmonary Disease
CRC With Chronic Obstructive Pulmonary Disease With Chronic Bronchitis

Interventions

DRUG
OTHER
DIAGNOSTIC_TEST

Results Available

NCT05652868 | TERMINATED | PHASE1

227 participants

Clinical Study of Antibody-Drug Conjugate MYTX-011 in Subjects With Non-Small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2023-03-23
Completion:: 2025-10-31

Conditions

NSCLC
NSCLC Stage IV
NSCLC Stage IIIB
Non-Small Cell Lung Cancer
Advanced Non-Small Cell Squamous Lung Cancer
Advanced Non-Small Cell Lung Cancer
Advanced Non-Small Cell Non-Squamous Lung Cancer

Interventions

DRUG

No Results Yet

NCT05651594 | RECRUITING | PHASE2

40 participants

Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2023-03-07
Completion:: 2029-03-30

Conditions

Clinical Stage II Esophageal Adenocarcinoma AJCC v8
Clinical Stage III Esophageal Adenocarcinoma AJCC v8
Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
Locally Advanced Esophageal Adenocarcinoma
Locally Advanced Gastroesophageal Junction Adenocarcinoma
Metastatic Esophageal Adenocarcinoma
Metastatic Gastroesophageal Junction Adenocarcinoma
Unresectable Esophageal Adenocarcinoma
Unresectable Gastroesophageal Junction Adenocarcinoma

Interventions

PROCEDURE
DRUG
BIOLOGICAL
OTHER

No Results Yet

NCT05651438 | COMPLETED

86 participants

Pain, Fatigue and Sleep Quality of E-Athletes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2023-08-01
Completion:: 2023-11-01

Conditions

E-Athletes

Interventions

OTHER

No Results Yet

NCT05628974 | RECRUITING

400 participants

Normal Donor Blood Draws for Platelet Studies and Biomarker Evaluation (ND-PLT)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2020-05-01
Completion:: 2030-12-31

Conditions

Healthy

No Results Yet

NCT05617599 | RECRUITING

508 participants

SUPRAFLEX CRUZ PMCF Study ( rEpic05 )

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2023-05-10
Completion:: 2026-12-01

Conditions

Coronary Artery Disease (CAD)
Ischemic Heart Disease

Interventions

DEVICE

No Results Yet

NCT05592223 | COMPLETED | PHASE1

20 participants

Phase I Open Label BCG Clinical Trial Assessing TB Drugs and Vaccines

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-12-06
Completion:: 2023-08-23

Conditions

Tuberculosis

Interventions

DRUG

Results Available

NCT05556772 | ACTIVE_NOT_RECRUITING | NA

619 participants

Optimizing Screening for Cervical Cancer Among Women Living With HIV in the Dominican Republic

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-11-14
Completion:: 2025-10-31

Conditions

Malignant Female Reproductive System Neoplasm

Interventions

PROCEDURE
OTHER

No Results Yet

NCT05547984 | RECRUITING | NA

100 participants

Ceramic Modular Dual Mobility in Primary Total Hip Arthroplasty (THA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-11-21
Completion:: 2027-09-30

Conditions

Coxarthrosis; Primary

Interventions

DEVICE

No Results Yet

NCT05522972 | RECRUITING | NA

180 participants

Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-09-13
Completion:: 2029-08-31

Conditions

Amblyopia

Interventions

BEHAVIORAL

No Results Yet

NCT05503550 | NO_LONGER_AVAILABLE

Pre-Approval Access Single Patient Request for Talquetamab in Relapsed or Refractory Multiple Myeloma

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-12-16

Conditions

Relapsed or Refractory Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05458648 | COMPLETED

37 participants

Single Center Pilot Study Using the ECGenius System to Collect Electrogram Data to Test an Ablation Impact Algorithm

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-07-28
Completion:: 2023-10-30

Conditions

Persistent Atrial Fibrillation
Cardiac Arrhythmia

Interventions

PROCEDURE

Results Available

NCT05456880 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

15 participants

BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-08-30
Completion:: 2028-02-29

Conditions

Sickle Cell Disease

Interventions

BIOLOGICAL

No Results Yet

NCT05443594 | COMPLETED | NA

669 participants

A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2023-02-28
Completion:: 2025-02-11

Conditions

Persistent Atrial Fibrillation

Interventions

DEVICE

Results Available

NCT05419362 | COMPLETED | PHASE2

42 participants

GEN-001 in Combination With Avelumab for Patients With PD-L1 Positive Gastric Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-04-07
Completion:: 2024-08-26

Conditions

Gastric Cancer
Gastroesophageal Junction Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT05391126 | RECRUITING | NA

178 participants

GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-09-28
Completion:: 2027-05-31

Conditions

Colorectal Cancer
Pancreatic Cancer

Interventions

DRUG

No Results Yet

NCT05389332 | RECRUITING | NA

114 participants

A Mobile Health Intervention Among Hispanics

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2025-04-20
Completion:: 2026-10-31

Conditions

Cancer of Skin

Interventions

BEHAVIORAL

No Results Yet

NCT05381454 | COMPLETED | PHASE1/PHASE2

80 participants

An Open Label Study in Adults to Test the Efficacy of Mitoquinone/Mitoquinol Mesylate to Prevent Severe Viral Illness

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-04-28
Completion:: 2023-05-09

Conditions

Respiratory Viral Infection
Antiviral Treatment
COVID-19

Interventions

DRUG

Results Available

NCT05367063 | COMPLETED | PHASE4

45 participants

Canagliflozin and Myocardial Fibrosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-01-05
Completion:: 2024-12-31

Conditions

Type 2 Diabetes
Cardiovascular Risk

Interventions

DRUG

No Results Yet

NCT05313009 | TERMINATED | PHASE1/PHASE2

5 participants

Tarlox and Sotorasib in Patients With KRAS G12C Mutations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-03-07
Completion:: 2023-07-07

Conditions

Non-Small Cell Lung Cancer

Interventions

DRUG

Results Available

NCT05296512 | ACTIVE_NOT_RECRUITING | PHASE2

30 participants

Pembrolizumab and Lenvatinib in Clear Cell Ovarian Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-09-23
Completion:: 2026-09-23

Conditions

Ovarian Clear Cell Carcinoma
Gynecologic Cancer

Interventions

DRUG

No Results Yet

NCT05271578 | COMPLETED | NA

55 participants

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-06-07
Completion:: 2025-06-06

Conditions

Vascular Reactivity
Serum Biomarkers

Interventions

DEVICE

No Results Yet

NCT05263830 | RECRUITING

240 participants

Glypican-3 as a Prognostic Factor in Patients With Hepatocellular Carcinoma Treated by Immunotherapy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2023-09-08
Completion:: 2029-09-08

Conditions

Hepatocellular Carcinoma

Interventions

OTHER

No Results Yet

NCT05256875 | TERMINATED

90 participants

An Analysis to Assess Non-adherence in People With Type 2 Diabetes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-08-30
Completion:: 2025-06-17

Conditions

Diabetes Mellitus, Type 2
Hypertension
Medication Adherence

Interventions

OTHER

No Results Yet

NCT05253287 | COMPLETED | PHASE2/PHASE3

96 participants

Growth Hormone in Decompensated Liver Cirrhosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-02-01
Completion:: 2024-12-31

Conditions

Liver Cirrhosis
Fibrosis
End Stage Liver Disease
Digestive System Disease
Physiological Effect of Drugs
Growth Hormone Treatment
Sarcopenia

Interventions

DRUG

No Results Yet

NCT05234372 | COMPLETED | NA

468 participants

MiVacunaLA: an Intervention to Improve COVID-19 Vaccination Behaviors Among Latinos

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-06-01
Completion:: 2022-11-30

Conditions

COVID-19 Pandemic

Interventions

BEHAVIORAL

No Results Yet

NCT05220631 | ACTIVE_NOT_RECRUITING | NA

369 participants

Digital Nutrition Intervention for Older Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-06-01
Completion:: 2024-09-30

Conditions

Nutrition Poor
Physical Inactivity
Social Isolation

Interventions

BEHAVIORAL

No Results Yet

NCT05217927 | COMPLETED | PHASE4

1415 participants

Efficacy and Safety Study of Rimegepant in Episodic Migraine Prevention With Multiple Dosing Regimens

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-03-04
Completion:: 2024-10-22

Conditions

Migraine

Interventions

DRUG

Results Available

NCT05211830 | COMPLETED | PHASE1/PHASE2

9 participants

A Study to Evaluate Topically Applied SXR1096 Cream in Patients With Netherton Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2021-12-07
Completion:: 2025-06-10

Conditions

Netherton Syndrome

Interventions

DRUG

No Results Yet

NCT05195060 | COMPLETED

1178 participants

TURN-COVID Biobank: The Dutch Cohort Study for the Evaluation of the Use of Neutralizing Monoclonal Antibodies and Other Antiviral Agents Against SARS-CoV-2

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2021-12-14
Completion:: 2025-09-01

Conditions

COVID-19

Interventions

DRUG

No Results Yet

NCT05165433 | COMPLETED | PHASE1

14 participants

Study of NG-350A Plus Pembrolizumab in Metastatic or Advanced Epithelial Tumours (FORTIFY)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-04-13
Completion:: 2025-08-29

Conditions

Epithelial Tumor
Metastatic Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT05161598 | NO_LONGER_AVAILABLE

Pre-approval Access Single Patient Request for Teclistamab (JNJ-64007957)

Study Type:: EXPANDED_ACCESS
Last Updated:: 2025-12-16

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05133492 | ACTIVE_NOT_RECRUITING | NA

46 participants

First In Human Study for Small to Medium-sized Abdominal Aortic Aneurysm (AAA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2019-06-24
Completion:: 2026-12-31

Conditions

Abdominal Aortic Aneurysm
AAA
Dilation Aorta

Interventions

DEVICE

No Results Yet

NCT05117515 | COMPLETED

200 participants

Retrospective Study of the Uni-Graft® K DV Patch in the Clinical Routine

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2022-04-27
Completion:: 2024-11-27

Conditions

Femoral Artery Stenosis
Iliac Artery Stenosis
Carotid Artery Stenosis

Interventions

DEVICE

No Results Yet

NCT05116943 | RECRUITING

100 participants

Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2013-08-19
Completion:: 2030-01-31

Conditions

Amyotrophic Lateral Sclerosis

No Results Yet

NCT05097274 | RECRUITING

50 participants

The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-16
Start Date:: 2015-10-15
Completion:: 2027-12-31

Conditions

Prostate Cancer
BRCA Mutation
Mismatch Repair Gene Mutation
ATM Gene Mutation
HOXB13 Germline Mutation
CHEK2 Gene Mutation
PALB2 Gene Mutation

Interventions

OTHER

No Results Yet

NCT05077332 | COMPLETED | PHASE2

4 participants

LEAP-CT for Treatment of COVID-19 Patients (Master Protocol)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2021-12-29
Completion:: 2025-11-10

Conditions

2019 Novel Coronavirus Disease
2019 Novel Coronavirus Infection
2019-nCoV Disease
2019-nCoV Infection
COVID-19 Pandemic
COVID-19 Virus Disease
COVID-19 Virus Infection
Covid19
Coronavirus Disease 2019
SARS-CoV-2 Infection
SARS-CoV-2 Acute Respiratory Disease
COVID-19

Interventions

DRUG
OTHER

No Results Yet

NCT05065580 | COMPLETED | NA

25 participants

OMT as an Adjunctive Treatment in MDD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-16
Start Date:: 2021-03-12
Completion:: 2023-03-23

Conditions

Major Depressive Disorder

Interventions

PROCEDURE

No Results Yet