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The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.

NCT05097274 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-12-16

No results posted yet for this study

Summary

The aim of the study is to determine if PET-CT imaging (using contrast recommended in clinical guidelines) is superior to combined bone scan and MRI/CT of the abdomen \& pelvis in detecting the increased incidence of metastasis (nodal/distant outside the pelvis) in men with prostatic carcinoma with mutations in any of the following germline DNA repair genes BRCA1, BRCA2, MSH2, MSH6, MLH1, PMS2, CHEK2, PALB2, ATM.

Conditions

  • Prostate Cancer
  • BRCA Mutation
  • Mismatch Repair Gene Mutation
  • ATM Gene Mutation
  • HOXB13 Germline Mutation
  • CHEK2 Gene Mutation
  • PALB2 Gene Mutation

Interventions

OTHER

MRI pelvis or CT imaging under clinical management for Pr Ca

Individuals to undergo a clinical MRI or CT scan of Pelvis and the study reviews the images.

OTHER

Whole body bone scan imaging

bone scan of the whole body (under clinical diagnosis).

OTHER

PET-CT imaging

Pt will undergo a PET-CT for their clinical treatment and we will review the images of this scan.

Sponsors & Collaborators

  • Cancer Research UK

    collaborator OTHER

  • National Institute for Health Research, United Kingdom

    collaborator OTHER_GOV

  • Institute of Cancer Research, United Kingdom

    lead OTHER

Principal Investigators

  • Rosalind A Eeles, FRCP FRCR · Institute of Cancer Research and Royal Marsden Hospital

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-15
Primary Completion
2027-12-31
Completion
2032-12-31

Countries

  • United Kingdom

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05097274 on ClinicalTrials.gov