Clinical Trials Updated in 2025

NCT04507126 | COMPLETED | PHASE2

20 participants

A Pilot Study of the Effects of BCG Immunization on CSF and Blood-based Biomarkers in Older Adults.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-03-01
Completion:: 2022-12-09

Conditions

Healthy

Interventions

BIOLOGICAL

Results Available

NCT04481451 | WITHDRAWN | PHASE4

0 participants

Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-12-01
Completion:: 2025-12-01

Conditions

Pain, Postoperative
Regional Anesthesia
Hip Dysplasia

Interventions

PROCEDURE
DRUG

No Results Yet

NCT04325529 | ACTIVE_NOT_RECRUITING

148 participants

Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.2 (Stress Manipulation)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-01-19
Completion:: 2026-06-30

Conditions

Major Depression in Remission

Interventions

DEVICE

No Results Yet

NCT04278521 | ACTIVE_NOT_RECRUITING | NA

54 participants

Mechanism of Action of Transcranial Magnetic Stimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2011-11-30
Completion:: 2026-06-30

Conditions

Major Depressive Disorder
Depression

Interventions

DEVICE

No Results Yet

NCT04270409 | ACTIVE_NOT_RECRUITING | PHASE3

337 participants

Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-06-16
Completion:: 2030-10-14

Conditions

Plasma Cell Myeloma

Interventions

DRUG

No Results Yet

NCT04266041 | COMPLETED | NA

122 participants

High-density EEG in Neurological Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-02-09
Completion:: 2024-05-31

Conditions

Epilepsy
Tumor
Healthy

Interventions

DIAGNOSTIC_TEST

Results Available

NCT04230096 | COMPLETED | NA

108 participants

Effects Of Low Level Laser Therapy On Tooth Movement,Treatment Related Complications Of Gingivitis,Periodontitis And Pain In Fixed Orthodontic Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2023-12-01
Completion:: 2024-02-28

Conditions

Gingivitis
Pain
Periodontitis
Tooth Migration

Interventions

DEVICE

No Results Yet

NCT04175041 | ACTIVE_NOT_RECRUITING | NA

104 participants

A Dose-Response Study of the Cognitive and Physiological Effects of tDCS to the DLPFC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-07-09
Completion:: 2026-05-31

Conditions

Attention Deficit Hyperactivity Disorder

Interventions

DEVICE

No Results Yet

NCT04175028 | COMPLETED | NA

83 participants

Neuromodulation of Executive Function in the ADHD Brain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2014-09-30
Completion:: 2018-06-01

Conditions

Attention Deficit Hyperactivity Disorder

Interventions

DEVICE

No Results Yet

NCT04166526 | RECRUITING

8 participants

A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-10-25
Completion:: 2027-05-01

Conditions

Sickle Cell Disease

Interventions

DEVICE

No Results Yet

NCT04145518 | COMPLETED | PHASE4

183 participants

Mechanistic Characterization of Uterine Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-10-25
Completion:: 2025-07-23

Conditions

Dysmenorrhea (Disorder)
Dysmenorrhea Primary
Dysmenorrhea Secondary
Endometrial Diseases
Leiomyoma
Fibroid Uterus

Interventions

DRUG

No Results Yet

NCT04122079 | COMPLETED

1120 participants

Validation of the Spanish Version of the Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) in Chile

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-01-09
Completion:: 2021-09-30

Conditions

Psychological Distress

No Results Yet

NCT04121091 | COMPLETED | PHASE2

13 participants

Pramipexole to Target "Anhedonic Depression"

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-10-04
Completion:: 2021-03-18

Conditions

Depression, Bipolar
Depression, Unipolar
Dysthymia
Anhedonia

Interventions

DRUG

Results Available

NCT04075890 | COMPLETED | NA

66 participants

Arbitration Between Habitual and Goal-directed Behavior in Obsessive-compulsive Disorder: Circuit Dynamics and Effects of Noninvasive Neurostimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-07-15
Completion:: 2024-01-31

Conditions

OCD
Decision-Making
tDCS
fMRI

Interventions

DEVICE

Results Available

NCT04027881 | COMPLETED | NA

15 participants

Improving Print Knowledge for Children With Hearing Loss

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-01-10
Completion:: 2021-05-20

Conditions

Hearing Loss

Interventions

BEHAVIORAL

No Results Yet

NCT04027257 | COMPLETED | NA

20 participants

Sit Together and Read (STAR): A Pilot Study of Children and Their Kinship Caregivers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-10-01
Completion:: 2021-05-31

Conditions

Reading

Interventions

BEHAVIORAL

No Results Yet

NCT03999424 | COMPLETED | PHASE1

5 participants

Autologous Human Schwann Cells in Peripheral Nerve Repair

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-09-24
Completion:: 2025-12-04

Conditions

Peripheral Nerve Injuries

Interventions

BIOLOGICAL

No Results Yet

NCT03919162 | TERMINATED | PHASE2

112 participants

A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2021-11-15
Completion:: 2024-07-12

Conditions

Alzheimer Disease

Interventions

DRUG
OTHER

Results Available

NCT03864510 | COMPLETED

317 participants

NAFLD in Diabetes Type 2 in Primary Care

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-04-01
Completion:: 2023-12-01

Conditions

NAFLD

No Results Yet

NCT03851796 | COMPLETED | NA

418 participants

Parent Involvement in Adolescent Obesity Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-05-23
Completion:: 2024-10-26

Conditions

Pediatric Obesity

Interventions

BEHAVIORAL

Results Available

NCT03808467 | ACTIVE_NOT_RECRUITING | NA

100 participants

Cognitive Training for Patients With Eating Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-03-01
Completion:: 2024-06-22

Conditions

Feeding and Eating Disorders
Anorexia Nervosa
Bulimia Nervosa
Binge-Eating Disorder

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT03761121 | RECRUITING | NA

300 participants

Developing Fast Pediatric Imaging

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-04-15
Completion:: 2027-09-01

Conditions

Pediatric Low-grade Gliomas

Interventions

OTHER

No Results Yet

NCT03744975 | COMPLETED | PHASE2

72 participants

PDD in Type 2 Diabetes w/wo Diastolic Dysfunction

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-05-01
Completion:: 2025-08-27

Conditions

Diabetes Mellitus, Type 2
Diastolic Dysfunction

Interventions

DRUG

No Results Yet

NCT03698552 | TERMINATED | PHASE1/PHASE2

37 participants

ADCT-602 in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-08-24
Completion:: 2025-11-06

Conditions

Blasts 5 Percent or More of Bone Marrow Nucleated Cells
CD22 Positive
Philadelphia Chromosome Positive
Recurrent B Acute Lymphoblastic Leukemia
Refractory B Acute Lymphoblastic Leukemia

Interventions

BIOLOGICAL

No Results Yet

NCT03684343 | TERMINATED | NA

48 participants

Comparative Analysis of Filmed Sequences for the Assessment of Discomfort in Atopic Dermatitis of Infants Under 6 Months of Age

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2020-01-13
Completion:: 2021-10-15

Conditions

Atopic Dermatitis

Interventions

OTHER

No Results Yet

NCT03640624 | ACTIVE_NOT_RECRUITING | NA

106 participants

Multidisciplinary Treatment of Chronic Vulvar Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-09-18
Completion:: 2024-11-10

Conditions

Vulvodynia
Chronic Pain

Interventions

COMBINATION_PRODUCT

No Results Yet

NCT03553095 | ACTIVE_NOT_RECRUITING | NA

92 participants

Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-07-12
Completion:: 2019-12-30

Conditions

Chronic Periodontitis
Depression

Interventions

PROCEDURE

No Results Yet

NCT03463317 | COMPLETED | PHASE4

912 participants

Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-02-28
Completion:: 2024-11-30

Conditions

Atrial Fibrillation

Interventions

DEVICE
DRUG

No Results Yet

NCT03422198 | RECRUITING | PHASE3

188 participants

Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-02-02
Completion:: 2026-11-30

Conditions

Endometrial Clear Cell Adenocarcinoma
Endometrial Endometrioid Adenocarcinoma
Endometrial Serous Adenocarcinoma
Stage I Uterine Corpus Cancer
Stage IA Uterine Corpus Cancer
Stage IB Uterine Corpus Cancer
Stage II Uterine Corpus Cancer
Uterine Corpus Carcinosarcoma
Uterine Corpus Sarcoma

Interventions

RADIATION

Results Available

NCT03360539 | ACTIVE_NOT_RECRUITING | NA

5670 participants

Nurse-Family Partnership Impact Evaluation in South Carolina

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2016-04-01
Completion:: 2023-04-01

Conditions

Preterm Birth
Injuries
Maternal Behavior

Interventions

BEHAVIORAL

Results Available

NCT03347838 | ACTIVE_NOT_RECRUITING | PHASE2

19 participants

Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2019-01-30
Completion:: 2025-06-18

Conditions

Bronchial Dysplasia
Tobacco Smoking
History of Non-Small Cell Lung Cancer
History of Head and Neck Cancer

Interventions

DRUG

Results Available

NCT03310957 | COMPLETED | PHASE1/PHASE2

185 participants

Safety and Efficacy of SGN-LIV1A Plus Pembrolizumab for Patients With Locally-Advanced or Metastatic Triple-Negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-02-27
Completion:: 2024-09-30

Conditions

Triple Negative Breast Neoplasms

Interventions

DRUG

Results Available

NCT03244852 | WITHDRAWN

0 participants

Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCD

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-12
Start Date:: 2017-09-15
Completion:: 2022-01-31

Conditions

Obsessive-Compulsive Disorder

No Results Yet

NCT03075306 | COMPLETED | NA

112 participants

Randomized Trial of a Healthy Weight Intervention for Youth With Serious Emotional Disturbance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2018-02-02
Completion:: 2021-02-19

Conditions

Weight Loss

Interventions

BEHAVIORAL

No Results Yet

NCT02926196 | COMPLETED | PHASE3

474 participants

Adjuvant Treatment for High-risk Triple Negative Breast Cancer Patients With the Anti-PD-l1 Antibody Avelumab

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2016-06-17
Completion:: 2024-06-30

Conditions

Triple Negative Breast Neoplasms

Interventions

DRUG

No Results Yet

NCT02885051 | TERMINATED | NA

91 participants

Evaluation of Pain in Preterm Newborn

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2017-01-16
Completion:: 2018-01-24

Conditions

Pain
Preterm Newborn

Interventions

PROCEDURE

No Results Yet

NCT02772562 | TERMINATED | PHASE2

33 participants

Adjuvant PROSTVAC-V/F in Subjects at High Risk for Relapse After Radical Prostatectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2016-07-18
Completion:: 2024-04-29

Conditions

Prostatic Neoplasms

Interventions

BIOLOGICAL

Results Available

NCT02723773 | COMPLETED | PHASE3

7539 participants

A Long-term Follow-up Study (ZOE-LTFU) of Two Studies 110390 (ZOSTER-006) and 113077 (ZOSTER-022) to Assess the Efficacy, Safety, and Immunogenicity Persistence of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine and Assessment of 1 or 2 Additional Doses in Two Subgroups of Older Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2016-04-16
Completion:: 2023-06-28

Conditions

Herpes Zoster
Herpes Zoster Vaccine

Interventions

BIOLOGICAL

Results Available

NCT02649751 | TERMINATED | PHASE2

49 participants

Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2016-02-22
Completion:: 2018-07-26

Conditions

Cystic Fibrosis

Interventions

DRUG

No Results Yet

NCT02344355 | ACTIVE_NOT_RECRUITING | PHASE2

90 participants

A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-12
Start Date:: 2017-03-13
Completion:: 2026-12-31

Conditions

Glioblastoma Multiforme

Interventions

DRUG
RADIATION

No Results Yet