Clinical Trials Updated in 2025

NCT07274384 | NOT_YET_RECRUITING | PHASE2

74 participants

Hyperprogression in PD-L1 ≥ 50% NSCLC: a Biomarker Guided Phase 2 Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-01-01
Completion:: 2029-12-31

Conditions

NSCLC (Non-small Cell Lung Cancer)
Hyperprogression

Interventions

COMBINATION_PRODUCT
DRUG

No Results Yet

NCT07274358 | COMPLETED | NA

15 participants

HopeMove App in Pediatric Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-08-01
Completion:: 2025-11-15

Conditions

Physical Activity
Mobile Application

Interventions

OTHER

No Results Yet

NCT07274345 | NOT_YET_RECRUITING

2000 participants

Prevalence and Risk Factors of Antiviral Resistance in Egyptian HBV Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-12-01
Completion:: 2026-06-01

Conditions

Chronic Hepatitis B - Antiviral Drug Resistance - Hepatitis B Virus (HBV) Infection

No Results Yet

NCT07274332 | NOT_YET_RECRUITING | NA

36 participants

Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-12-22
Completion:: 2026-01-31

Conditions

Vagus Nerve Stimulation
Autonomic Nervous System
Heart Rate
Blood Pressure
Respiration
Healthy Volunteers

Interventions

DEVICE

No Results Yet

NCT07274319 | NOT_YET_RECRUITING | NA

40 participants

EFFICACY OF TRANSMUCOSAL MINIPLEITE STABILIZATION TECHNIQUE VERSUS INTRA-ARCH WIRE STABILIZATION TECHNIQUE FOR FIXATION OF SAGITTAL & PARA-SAGITTAL TYPES OF PALATAL FRACTURES IN TERMS OF INTRA-ARCH MOLAR DISTANCE & MAXILLO-MANDIBULAR MOLAR RELATION

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-09-01
Completion:: 2027-02-28

Conditions

Sagittal and Parasagittal Palatal Fracture

Interventions

PROCEDURE

No Results Yet

NCT07274306 | ACTIVE_NOT_RECRUITING

2446 participants

Incidence, Treatment and Outcome After Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-02-24
Completion:: 2025-12-31

Conditions

Mesenteric Artery Ischemia

No Results Yet

NCT07274293 | COMPLETED | NA

50 participants

EVALUATION OF THE TOLERABILITY AND BIOMEDICAL POTENTIAL OF A GARMENT CONTAINING PRINTED CERAMICS IN MUSCULAR PAIN

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-05-06
Completion:: 2025-06-12

Conditions

Cervical Pain
Lumbar Pain
Muscular
Chronic Pain (Back / Neck)
Pain Management

Interventions

DEVICE

No Results Yet

NCT07274202 | NOT_YET_RECRUITING | NA

84 participants

The Physical and Mental Impact of ART: IVM vs Conventional Ovarian Stimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-01-31
Completion:: 2028-01-31

Conditions

PCOS (Polycystic Ovary Syndrome)

Interventions

OTHER

No Results Yet

NCT07274150 | NOT_YET_RECRUITING

50 participants

Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage in the Prehospital and Emergency Room Setting

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-02-01
Completion:: 2028-02-01

Conditions

Exanguination
Polytrauma
NCTH

No Results Yet

NCT07274124 | NOT_YET_RECRUITING | NA

36 participants

Pain Neuroscience Education and Vagus Nerve Stimulation on Recovery in Individuals With Rheumatoid Arthritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-01-31
Completion:: 2027-05-31

Conditions

Rheumatic Diseases
Rheumatoid Arthritis (RA)

Interventions

OTHER

No Results Yet

NCT07274111 | COMPLETED | NA

66 participants

Virtual Reality as a Nursing Intervention for Anxiety and Pain in Pediatric Endoscopy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-06-03
Completion:: 2025-09-30

Conditions

Gastrointestinal Endoscopy
Procedural Anxiety
Pain

Interventions

BEHAVIORAL

No Results Yet

NCT07274098 | COMPLETED | NA

10 participants

To Test Effectiveness of Virtual Reality on Post Operative Patients 'VR-RAP@

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-04-16
Completion:: 2025-06-09

Conditions

Colo-rectal Surgery

Interventions

DEVICE

No Results Yet

NCT07274085 | RECRUITING | PHASE1

96 participants

A Phase 1 Study of HDM2017 in Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-11-18
Completion:: 2026-12-31

Conditions

Solid Tumors

Interventions

DRUG

No Results Yet

NCT07274072 | RECRUITING

200 participants

Hospital at Home Versus Inpatient Care: Costs and Effectiveness

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-09-01
Completion:: 2026-08-31

Conditions

Costs and Cost Analysis
Effectiveness
Patient Satisfaction

No Results Yet

NCT07274059 | RECRUITING | EARLY_PHASE1

48 participants

Allogeneic UCB-derived CAR-T for SLE

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-03-26
Completion:: 2035-12-31

Conditions

SLE - Systemic Lupus Erythematosus

Interventions

DRUG

No Results Yet

NCT07274046 | RECRUITING

209 participants

Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-10
Start Date:: 2023-04-01
Completion:: 2025-12-31

Conditions

Tick Borne Encephalitis (TBE)

Interventions

OTHER

No Results Yet

NCT07274020 | NOT_YET_RECRUITING | PHASE3

140 participants

Long-Term Safety and Efficacy of Moxifloxacin in Bronchiectasis Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-12-01
Completion:: 2026-12-01

Conditions

Bronchiectasis, Non-Cystic Fibrosis

Interventions

DRUG
OTHER

No Results Yet

NCT07274007 | ACTIVE_NOT_RECRUITING | NA

24 participants

Traumatic Injury of Spleen:Laparoscopic Splenectomy Vs Splenic Artery Embolization

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2024-12-01
Completion:: 2025-05-31

Conditions

Grade III Traumatic Splenic Injury in Hemodynamically Stable Patients

Interventions

PROCEDURE

No Results Yet

NCT07273994 | RECRUITING | PHASE4

312 participants

Evaluation of Two Different Regimens of the Antiarrhythmic Drug Amiodarone to Maintain Normal Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-11-01
Completion:: 2027-12-31

Conditions

Persistent Atrial Fibrillation

Interventions

DRUG

No Results Yet

NCT07273981 | NOT_YET_RECRUITING | PHASE2

30 participants

Zanidatamab Combined With Chemotherapy as Neoadjuvant Therapy for HER2-high Expression G/GEJC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-01-01
Completion:: 2028-06-30

Conditions

Gastric/Gastroesophageal Junction Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT07273955 | RECRUITING

20 participants

Alcohol Use Disorder Before and After Bariatric Surgery and the Impact of Considering This Surgery During Addiction Follow-up

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-10
Start Date:: 2023-12-12
Completion:: 2025-12-12

Conditions

Alcohol Use Disorder

No Results Yet

NCT07273916 | NOT_YET_RECRUITING | PHASE2

20 participants

Evaluation of the Efficacy and Onset of Action of a Topical Anesthetic Marker

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-03-31
Completion:: 2026-05-31

Conditions

Pain Management

Interventions

DRUG

No Results Yet

NCT07273890 | NOT_YET_RECRUITING | NA

576 participants

Real-time Feedback of Red-out Within Colonoscopy Intubation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-12-10
Completion:: 2027-08-31

Conditions

Artificial Intelligence
Colonoscopy
Real-time Feedback

Interventions

OTHER

No Results Yet

NCT07273864 | COMPLETED | NA

60 participants

Effect of Median Nerve Electrical Stimulation Combined With Auricular Acupuncture on Consciousness Disturbance in Patients With Craniocerebral Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2022-02-10
Completion:: 2023-11-30

Conditions

Traumatic Brain Injury
Cerebral Hemorrhage

Interventions

OTHER
DEVICE

No Results Yet

NCT07273825 | COMPLETED | NA

90 participants

The Effect of Geranium Essential Oil Aromatherapy on Fatigue and Sleep Quality in Patients Undergoing Hemodialysis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-01-01
Completion:: 2025-09-30

Conditions

Aromatherapy (Geranium Essential Oil)
Chronic Kidney Disease on Hemodialysis
End Stage Renal Disease (ESRD)
Fatigue
Poor Sleep Quality
Aromatherapy

Interventions

OTHER

No Results Yet

NCT07273799 | NOT_YET_RECRUITING | PHASE3

200 participants

Comparison of Outcomes Between Topical Minoxidil Versus Oral Minoxidil for the Treatment of Androgenetic Alopecia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-12-20
Completion:: 2026-05-01

Conditions

Androgenic Alopecia

Interventions

DRUG

No Results Yet

NCT07273786 | ACTIVE_NOT_RECRUITING | NA

38 participants

The Effects of Group Social Work Intervention on Children's Emotional Intelligence, Emotion Regulation Skills and Empathy Tendencies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-03-05
Completion:: 2025-11-06

Conditions

Emotional Intelligence
Emotion Regulation
Empathy Skills

Interventions

BEHAVIORAL

No Results Yet

NCT07273760 | COMPLETED

150 participants

VedAryo® (Vedolizumab) Effectiveness and Safety Evaluation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-10
Start Date:: 2023-07-16
Completion:: 2025-09-30

Conditions

Ulcerative Colitis (UC)
Crohn Disease (CD)
Inflammatory Bowel Disease (IBD)

Interventions

DRUG

No Results Yet

NCT07269587 | ACTIVE_NOT_RECRUITING

275 participants

A Real-world Study on the Treatment of Adult B-cell Acute Lymphoblastic Leukemia With CNCT-19

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-11-07
Completion:: 2027-11-30

Conditions

ALL (Acute B-Lymphoblastic Leukemia)
CAR-T Cell Therapy

Interventions

DRUG

No Results Yet

NCT07264608 | NOT_YET_RECRUITING | NA

76 participants

4-Point TAP Block vs. Combined RSB-OSTAP Block for Recovery After Laparoscopic Cholecystectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-12-30
Completion:: 2026-04-15

Conditions

Postoperative Pain
Quality of Recovery

Interventions

PROCEDURE

No Results Yet

NCT07263646 | NOT_YET_RECRUITING | NA

80 participants

The Effect of Balance-focused Exercise Programme in Enhancing the Solus-muscle Activation During Gait Initiation for People With Parkinson Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-01-22
Completion:: 2027-12-22

Conditions

Parkinson Disease
Gait Disorders
Gait Balance

Interventions

OTHER

No Results Yet

NCT07263321 | RECRUITING | NA

171 participants

Improving Treatment for Depression in General Practice Using a Step-by-Step Care Plan.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-12-31
Completion:: 2027-06-30

Conditions

Depressive Disorder
Depression - Major Depressive Disorder
Depressive Disorder, Major Depressive Disorder
Depressive Disorders
Depression
Depressive Episodes
Depressive Episode

Interventions

OTHER

No Results Yet

NCT07262008 | NOT_YET_RECRUITING | PHASE3

120 participants

Sustained Mood Improvement With Laughing Gas Exposure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-02-01
Completion:: 2027-02-01

Conditions

Major Depressive Disorder
Treatment Resistant Depression

Interventions

DRUG

No Results Yet

NCT07261644 | RECRUITING | PHASE3

500 participants

A Study to Evaluate the Efficacy and Safety of 608 in Adult Subjects With Active Ankylosing Spondylitis(AS)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-11-07
Completion:: 2027-01-14

Conditions

Ankylosing Spondylitis

Interventions

DRUG

No Results Yet

NCT07259798 | COMPLETED | NA

50 participants

Histopathological Findings in En-Bloc vs Conventional Transurethral Resection of Bladder Tumors.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2024-08-01
Completion:: 2025-02-01

Conditions

Urinary Bladder Cancer

Interventions

PROCEDURE

No Results Yet

NCT07259512 | RECRUITING | PHASE4

80 participants

Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-06-30
Completion:: 2025-12-31

Conditions

Chronic Kidney Disease
Heart Failure With Reduced Ejection Fraction (HFrEF)

Interventions

DRUG

No Results Yet

NCT07257640 | RECRUITING | PHASE1

20 participants

IL-5 CAR-T Cell Therapy for Refractory/Relapsed Eosinophilic Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-11-30
Completion:: 2028-11-30

Conditions

Hematologic Diseases
Neoplasms

Interventions

DRUG

No Results Yet

NCT07257601 | NOT_YET_RECRUITING | NA

72 participants

TDCS-RTMS Intervention for Motor Function

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-11-30
Completion:: 2027-06-30

Conditions

Locked in Syndrome

Interventions

DEVICE

No Results Yet

NCT07256340 | RECRUITING | NA

50 participants

Measuring Total Energy Expenditure in Critically Ill Patients Using the Doubly Labelled Water Method

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2025-12-01
Completion:: 2026-07-31

Conditions

Critical Illness

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT07254221 | NOT_YET_RECRUITING | PHASE4

400 participants

Rosuvastatin for Prevention of Anthracycline-induced Cardiac Dysfunction in Breast Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-10
Start Date:: 2026-02-01
Completion:: 2028-04-21

Conditions

Anthracycline-induced Cardiac Toxicity
Breast Cancer
Anthracycline Related Cardiotoxicity in Breast Cancer
Anthracycline-induced Cardiotoxicity

Interventions

DRUG

No Results Yet