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Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic

NCT07274046 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 209

Last updated 2025-12-10

No results posted yet for this study

Summary

This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic. The aim is to better understand how individuals recover from TBE, which symptoms may persist after the infection, and which patients may require additional support during their recovery. Participants are examined several times after hospital discharge (at 2-4 weeks, 3 months, 6 months, and 12 months) to observe changes in symptoms, functional status, and daily activities. Follow-up assessments include evaluation of common post-infection problems such as tiredness, headaches, memory or concentration difficulties, sleep issues, or limb weakness. Symptoms lasting for several months are categorized as post-encephalitic syndrome (PES).

The study also assesses how TBE affects daily functioning, school and work performance, and overall quality of life using questionnaires and short functional assessments. In addition, the study includes a public-health component that estimates the broader impact of TBE in the population and evaluates the potential benefits of vaccination in preventing long-term health complications.

The findings aim to support improved patient care, follow-up planning, and evidence-based public-health decision-making in the Czech Republic.

Conditions

  • Tick Borne Encephalitis (TBE)

Interventions

OTHER

No intervention

Observational study only. Participants receive standard clinical care; no experimental or study-specific interventions are administered.

Sponsors & Collaborators

  • České Budějovice Hospital

    collaborator OTHER

  • University Hospital Ostrava

    collaborator OTHER

  • Hospital Pardubice

    collaborator UNKNOWN

  • Bulovka Hospital

    collaborator OTHER

  • Charles University, Czech Republic

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-01
Primary Completion
2025-12-31
Completion
2026-12-31

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07274046 on ClinicalTrials.gov