Clinical Trials Updated in 2025

NCT07272213 | RECRUITING

180 participants

Thyroid-Stimulating Hormone Levels in Pregnancy and Their Association With Depression, Anxiety, and Sexual Function

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-11-01
Completion:: 2025-12-01

Conditions

Thyroid Disorders Complicating Pregnancy
Maternal Depression in Pregnancy, Unspecified Trimester
Anxiety Disorder, Unspecified
Sexual Dysfunction, Unspecified

No Results Yet

NCT07272200 | RECRUITING | NA

1000 participants

Understanding Gene ENvironment Interaction in ALcohol-related Hepatocellular Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2023-12-01
Completion:: 2026-12-31

Conditions

HCC
Genetic Predisposition

Interventions

OTHER

No Results Yet

NCT07272187 | RECRUITING

138 participants

Endoscopic Ultrasound-guided Radiofrequency Ablation for Upper Gastrointestinal Tract Lesions

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-11-01
Completion:: 2040-12-31

Conditions

Insulinoma; Pancreas
MEN1
NETs
Radiofrequency Ablation
Endoscopic Ultrasound (EUS)
Conn Syndrome

Interventions

OTHER

No Results Yet

NCT07272148 | ACTIVE_NOT_RECRUITING

125 participants

The Pilot of the Turku Outpatient Clinic for Functional and Fatigue Disorders

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2023-08-01
Completion:: 2026-05-31

Conditions

Persistent Physical Symptoms (PPS)
Functional Disorder
Fatigue Syndrome, Chronic

Interventions

BEHAVIORAL

No Results Yet

NCT07272135 | COMPLETED | PHASE1

12 participants

Selective β2-AR Antagonism in Asthma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2018-02-28
Completion:: 2022-08-16

Conditions

Asthma

Interventions

OTHER
DRUG

No Results Yet

NCT07272083 | NOT_YET_RECRUITING

200 participants

New Diagnostic Criteria in the Evaluation Response to Ablation Treatment of Hepatocellular Carcinoma Nodules

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-01
Completion:: 2028-12-01

Conditions

Hepatocellular Carcinoma

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT07272057 | NOT_YET_RECRUITING | NA

200 participants

SGLT2 Inhibitors and Survival in Lung Cancer Patients With Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-07
Completion:: 2026-10-07

Conditions

Lung Cancer

Interventions

DRUG
OTHER

No Results Yet

NCT07272044 | RECRUITING

500 participants

Research on Anesthesia Depth Control Strategy Based on Continuous and Non-invasive Monitoring of Exhaled Breath

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2024-03-16
Completion:: 2027-03-15

Conditions

Anesthesia

No Results Yet

NCT07272018 | NOT_YET_RECRUITING

480 participants

Maternal and Fetal Clinical Significance of Hypotension Following Labor Epidural Analgesia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-31
Completion:: 2026-02-28

Conditions

Maternal Hypotension
Labor Epidural Analgesia
Fetal Heart Rate Abnormalities

Interventions

OTHER

No Results Yet

NCT07271992 | NOT_YET_RECRUITING | PHASE2

30 participants

TREND-02 - a Phase II Exploratory De-escalation Trial of Neoadjuvant Sacituzumab Govitecan Plus Tislelizumab (SG/I) in Early Triple-negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-15
Completion:: 2030-12-14

Conditions

TNBC, Triple Negative Breast Cancer

Interventions

DRUG

No Results Yet

NCT07271953 | RECRUITING | NA

72 participants

The Effect of Motivational Interviewing and Digital Game-Supported Counseling on Postpartum Relapse

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-10-01
Completion:: 2026-06-30

Conditions

Postpartum Period
Smoking Relapse Behavior

Interventions

BEHAVIORAL

No Results Yet

NCT07271927 | RECRUITING | NA

15 participants

Whole-Body Photobiomodulation for Motor and Cognitive Changes in Parkinson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-02-12
Completion:: 2025-11-30

Conditions

PARKINSON DISEASE (Disorder)

Interventions

DEVICE

No Results Yet

NCT07271914 | NOT_YET_RECRUITING | NA

390 participants

PONDER: Pelvic Peritonectomy in Early Stage Ovarian Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2026-02-28
Completion:: 2030-02-28

Conditions

Early Stage Ovarian Tumors
Peritoneal Carcinosis

Interventions

PROCEDURE
DIAGNOSTIC_TEST

No Results Yet

NCT07271901 | COMPLETED | NA

100 participants

Masticatory Performance in Mixed Dentition Children Before and After Dental Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-01-30
Completion:: 2025-01-30

Conditions

Dental Caries

Interventions

OTHER

No Results Yet

NCT07271888 | NOT_YET_RECRUITING | NA

104 participants

Effect of Mendelsohn Maneuver, Effortful Swallow Training, and the Shaker Exercise on Swallowing Ability Among Dysphagic Patients With Cerebrovascular Accident

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-01
Completion:: 2026-02-28

Conditions

Neurogenic Dysphagia

Interventions

OTHER

No Results Yet

NCT07271875 | NOT_YET_RECRUITING | PHASE3

560 participants

Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2026-01-01
Completion:: 2027-11-30

Conditions

Postoperative Gastrointestinal Dysfunction (POGD)
Postoperative Ileus
Colorectal Surgery

Interventions

DRUG

No Results Yet

NCT07271862 | ACTIVE_NOT_RECRUITING | NA

60 participants

A Novel Laparoscopic Apical Promontofixation Technique With Simultaneous Perineal Reconstruction for Patients With Symptomatic Pelvic Organ Prolapse

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2024-08-29
Completion:: 2026-10-04

Conditions

Pelvic Organ Prolapse (POP)
Urinary Incontinence , Stress
Urinary Incontinence (UI)
Female Sexual Dysfunction (FSD)
Quality of Life

Interventions

PROCEDURE

No Results Yet

NCT07271849 | RECRUITING | PHASE4

162 participants

Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-10-28
Completion:: 2026-10-01

Conditions

Postoperative Pain, Acute
Hemodynamics
Total Knee Arthroplasty (TKA)

Interventions

DRUG
OTHER

No Results Yet

NCT07271823 | ACTIVE_NOT_RECRUITING

100 participants

Establishment of a Predictive Model for Immunotherapy Response in Pancreatic Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2024-09-01
Completion:: 2026-12-31

Conditions

Pancreatic Cancer Non-resectable

Interventions

OTHER

No Results Yet

NCT07271810 | COMPLETED

184 participants

Association Between Primary School Children's Speaking Attitudes and Oral Health Indicators

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2024-01-01
Completion:: 2025-01-01

Conditions

Dental Caries

Interventions

OTHER

No Results Yet

NCT07271797 | COMPLETED | NA

125 participants

Comparing Different Electronic Apex Locators and Periapical Radiography on Postoperative Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2023-10-01
Completion:: 2024-01-01

Conditions

Postoperative Acute Pain

Interventions

DEVICE

No Results Yet

NCT07271784 | COMPLETED

151 participants

Establishment of a Prediction Model for Postherpetic Neuralgia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2023-09-01
Completion:: 2024-05-24

Conditions

Pain
Neuropathic Pain
Biomarkers / Blood

No Results Yet

NCT07271745 | NOT_YET_RECRUITING

1740 participants

Multicenter Study on Early Arterial Changes in Prediabetic Patients Evaluated by Ultra-High-Frequency Ultrasound

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-15
Completion:: 2026-12-31

Conditions

Prediabetes

No Results Yet

NCT07271732 | NOT_YET_RECRUITING | NA

90 participants

Songling Xuemaikang Capsules for Cerebral Small Vessel Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-10
Completion:: 2026-12-31

Conditions

Hypertension
Cerebral Small Vessel Diseases

Interventions

DRUG

No Results Yet

NCT07271719 | ACTIVE_NOT_RECRUITING | NA

48 participants

Fovea Sparing ILM Peeling in Diabetic Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-06-05
Completion:: 2025-12-31

Conditions

Diabetes Mellitus

Interventions

PROCEDURE

No Results Yet

NCT07271706 | NOT_YET_RECRUITING | NA

80 participants

The Effect of Laughter Yoga in Type 2 Diabetes Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-15
Completion:: 2025-12-25

Conditions

Diabetic
Laughter Yoga
Comfort

Interventions

BEHAVIORAL

No Results Yet

NCT07271654 | COMPLETED | NA

160 participants

Can Pretreatment With Analgesics Reduce Postendodontic Pain?

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-08-01
Completion:: 2025-10-01

Conditions

Pulpitis - Irreversible

Interventions

PROCEDURE

No Results Yet

NCT07271641 | COMPLETED | NA

16 participants

A Study Comparing Two Different Denture Base Materials in Implant Retained Overdentures

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2024-07-15
Completion:: 2025-11-01

Conditions

Edentulous Alveolar Ridge In Mandible
Edentulous Jaw
Edentulous Mouth
Implant Supported Overdenture
Attachments
Dental Implant
Complete Edentulism

Interventions

PROCEDURE

No Results Yet

NCT07271628 | COMPLETED

24 participants

Evaluation of the Moisturizing Effect of Study Product AV0018B and the Persistence of This Effect After Repeated Applications, Compared to an Untreated Control Area.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-10-04
Completion:: 2021-10-28

Conditions

Dry Skin

Interventions

OTHER

No Results Yet

NCT07271602 | NOT_YET_RECRUITING | PHASE2

104 participants

A Phase 2 Randomized, Controlled Trial of QL1706 Plus Chemotherapy and Quad Shot for Driver Gene-negative Advanced Non-small Cell Lung Cancer.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2026-01-30
Completion:: 2026-12-31

Conditions

Non Small Cell Lung Cancer
Immunotherapy
Radiotherapy
Chemotherapy

Interventions

RADIATION
DRUG

No Results Yet

NCT07271576 | RECRUITING | NA

10 participants

Research on the Protective Effects of Phycocyanin Against Liver Fibrosis and Cirrhosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-06-04
Completion:: 2027-06-04

Conditions

Liver Fibrosis
Liver Cirrhosis

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT07271563 | COMPLETED

90 participants

Assessment of Pentraxin Levels in the Gingival Fluid of Abutment Teeth in the Context of the Use of Fixed Dentures

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2023-03-01
Completion:: 2024-08-01

Conditions

Periodontal Disease
Periodontal Diseases
Prosthodontics

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT07271550 | COMPLETED

255 participants

NAFF Arabic Validation Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2021-06-01
Completion:: 2021-11-30

Conditions

Type 2 Diabetes Mellitus (T2DM)
Diabetic Foot Disease
Behavior
Self Care
Questionnaire and Survey

No Results Yet

NCT07271537 | COMPLETED

352 participants

Karydakis Versus Limberg Flap for the Management of Primary Sacrococcygeal Pilonidal Sinus

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2017-07-01
Completion:: 2024-07-01

Conditions

Pilonidal Cyst and Sinus Without Abscess

Interventions

PROCEDURE

No Results Yet

NCT07271524 | NOT_YET_RECRUITING | NA

25 participants

Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-31
Completion:: 2027-12-31

Conditions

Traumatic Brain Injury

Interventions

OTHER

No Results Yet

NCT07271498 | COMPLETED

93 participants

The Oral cGVHD as a Predictive Factor of Graft Versus Leukaemia Effect in Patients Who Received an Allograft

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2023-10-01
Completion:: 2025-05-01

Conditions

Allografts
Oral cGVHD

Interventions

OTHER

No Results Yet

NCT07271485 | RECRUITING | EARLY_PHASE1

20 participants

Propranolol for Misophonia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2025-12-19
Completion:: 2026-12-19

Conditions

Misophonia
Propanolol
Misophonia Treatment

Interventions

DRUG

No Results Yet

NCT07271446 | COMPLETED | PHASE1

8 participants

An Autologous NK/CIK Cell Product (PB101) in Combination With EGFR-TKI for Treating Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2018-09-01
Completion:: 2019-08-01

Conditions

Non-small Cell Lung Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT07271420 | RECRUITING | PHASE4

40 participants

Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-09
Start Date:: 2020-01-01
Completion:: 2026-12-31

Conditions

Hypertension
Peritoneal Dialysis
End Stage Kidney Disease (ESRD)

Interventions

DRUG

No Results Yet

NCT07271394 | COMPLETED

25800 participants

The Impact of Methylprednisolone Sodium Succinate on Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgery: A Target Trial Emulation Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-09
Start Date:: 2018-10-01
Completion:: 2020-09-30

Conditions

Postoperative Delirium (POD)

Interventions

DRUG

No Results Yet