Clinical Trials Updated in 2025

NCT04944017 | COMPLETED | PHASE2

51 participants

Ketamine for the Treatment of Depression in Parkinson's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-11-23
Completion:: 2025-09-24

Conditions

Parkinson's Disease
Depression

Interventions

DRUG
OTHER

No Results Yet

NCT04936607 | RECRUITING | NA

1158 participants

ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-06-28
Completion:: 2027-01-30

Conditions

Contrast-Induced Acute Kidney Injury

Interventions

PROCEDURE

No Results Yet

NCT04932980 | ACTIVE_NOT_RECRUITING | NA

80 participants

Comparison of Rapid Aflibercept and Brolucizumab T&E in wAMD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2022-05-09
Completion:: 2027-06-30

Conditions

Wet Age-related Macular Degeneration

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04882878 | COMPLETED | PHASE2

228 participants

A Study of Nipocalimab in Adult Participants With Active Systemic Lupus Erythematosus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-08-20
Completion:: 2024-04-30

Conditions

Systemic Lupus Erythematosus

Interventions

OTHER
DRUG

No Results Yet

NCT04877379 | COMPLETED | PHASE1

53 participants

VNRX-7145 Drug-Drug Interaction in Healthy Adult Volunteers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-06-08
Completion:: 2021-11-10

Conditions

Healthy Subjects

Interventions

DRUG

No Results Yet

NCT04794634 | COMPLETED | NA

55 participants

Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-01-13
Completion:: 2023-06-23

Conditions

Optical Coherence Tomography
Optical Coherence Tomography Angiography
Retinal Thickening
Alzheimer Disease
Lewy Body Disease
Retina
Cortical Atrophy
Retinal Nerve Fibres Layer

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04767555 | ACTIVE_NOT_RECRUITING | NA

250 participants

Impact of ILM Peeling in RRD/ I-Peel

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2022-02-23
Completion:: 2026-04-30

Conditions

Retinal Detachment

Interventions

PROCEDURE

No Results Yet

NCT04759885 | COMPLETED | PHASE2/PHASE3

886 participants

Efficacy and Safety of mAnnitol in Bowel Preparation During Elective Colonoscopy and Comparison With Moviprep®

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-06-18
Completion:: 2021-07-16

Conditions

Elective Colonoscopy

Interventions

DRUG

Results Available

NCT04684914 | TERMINATED | PHASE2

87 participants

HepTcell Immunotherapy in Patients With Inactive Chronic Hepatitis B (CHB)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-12-26
Completion:: 2024-03-27

Conditions

Hepatitis B, Chronic

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04670666 | RECRUITING | PHASE3

270 participants

Efficacy and Safety of Madalena Association in the Treatment of Type II Diabetes Mellitus

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2024-11-18
Completion:: 2026-07-31

Conditions

Type 2 Diabetes Mellitus

Interventions

DRUG
OTHER

No Results Yet

NCT04602754 | RECRUITING | PHASE3

228 participants

Efficacy and Safety of Berlim 25/20 Association in the Treatment of Type II Diabetes Mellitus and Dyslipidemia.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2023-12-01
Completion:: 2026-05-31

Conditions

Dyslipidemia Associated With Type II Diabetes Mellitus

Interventions

DRUG
OTHER

No Results Yet

NCT04594018 | RECRUITING | PHASE3

190 participants

Efficacy and Safety of Finlândia Hair Lotion Association on Androgenetic Alopecia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2023-02-02
Completion:: 2026-05-31

Conditions

Androgenetic Alopecia

Interventions

DRUG

No Results Yet

NCT04577456 | COMPLETED | NA

44 participants

Chyme Reinfusion for Type 2 Intestinal Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2022-10-15
Completion:: 2025-11-17

Conditions

Intestinal Failure
Enterocutaneous Fistula
Ileostomy - Stoma
High Output Stoma

Interventions

DEVICE

No Results Yet

NCT04569058 | COMPLETED | NA

38 participants

Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-01-14
Completion:: 2024-10-31

Conditions

Autism
Attention Deficit Hyperactivity Disorder

Interventions

DEVICE

Results Available

NCT04538742 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

245 participants

A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-12-28
Completion:: 2025-01-31

Conditions

Metastatic Breast Cancer

Interventions

DRUG

No Results Yet

NCT04515446 | ACTIVE_NOT_RECRUITING | NA

18 participants

Quantification of Viral Load in the Upper Respiratory Tract in Patients Treated With Olsetamivir for Influenza

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-02-04
Completion:: 2023-03-10

Conditions

Flu

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04471792 | COMPLETED | PHASE2

13 participants

Creatine Use and Muscle Stretching in Peripheral Artery Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-05-12
Completion:: 2022-12-15

Conditions

Peripheral Arterial Disease

Interventions

DRUG
DIETARY_SUPPLEMENT

Results Available

NCT04430452 | RECRUITING | PHASE2

21 participants

Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2022-02-04
Completion:: 2028-07-31

Conditions

Advanced Hepatocellular Carcinoma
Stage III Hepatocellular Carcinoma AJCC v8
Stage IIIA Hepatocellular Carcinoma AJCC v8
Stage IIIB Hepatocellular Carcinoma AJCC v8
Stage IV Hepatocellular Carcinoma AJCC v8
Stage IVA Hepatocellular Carcinoma AJCC v8
Stage IVB Hepatocellular Carcinoma AJCC v8

Interventions

BIOLOGICAL
RADIATION

No Results Yet

NCT04415593 | COMPLETED | NA

44 participants

High and Low Dose Oral Peanut Immunotherapy - Comparison of Efficacy and Safety

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-09-01
Completion:: 2024-05-30

Conditions

Peanut Allergy

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04350502 | COMPLETED | NA

11 participants

Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2019-07-18
Completion:: 2025-12-01

Conditions

Pleural Infection
Empyema
Community-acquired Pneumonia
Pharmacokinetic
Amoxicillin

Interventions

PROCEDURE
BIOLOGICAL
DRUG

No Results Yet

NCT04259359 | RECRUITING

266 participants

Predominant Sensitizations to Single Bee Venom Allergens as a Risk Factor for Therapy Failure

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2019-05-02
Completion:: 2025-12-31

Conditions

Bee Venom Allergy

Interventions

DRUG

No Results Yet

NCT04235309 | COMPLETED

297 participants

Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME) Collaborative Phase 2

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-02-27
Completion:: 2023-10-30

Conditions

Resilience
Aging

No Results Yet

NCT04225507 | ACTIVE_NOT_RECRUITING | NA

174 participants

Technology-Supported Treatment of Sleep Apnea in Prediabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-04-13
Completion:: 2026-07-31

Conditions

Sleep Apnea
PreDiabetes
Overweight or Obesity

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT04210102 | ACTIVE_NOT_RECRUITING | NA

47 participants

Community-Acquired Pneumonia Diagnosis Using Lung Ultrasound in Emergency Room Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-02-11
Completion:: 2025-01-28

Conditions

Community-acquired Pneumonia

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04188119 | WITHDRAWN | PHASE2

0 participants

A Proof of Concept Window Trial of the IMmunological Effects of AveLumab and Aspirin in Triple-Negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2023-12-01
Completion:: 2024-09-30

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT04185441 | COMPLETED | PHASE3

295 participants

Efficacy and Safety of Tanzânia Association in the Treatment of Erectile Dysfunction Associated With Benign Prostatic Hyperplasia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-03-14
Completion:: 2023-10-10

Conditions

Erectile Dysfunction
Benign Prostatic Hyperplasia

Interventions

DRUG
OTHER

No Results Yet

NCT04178005 | ACTIVE_NOT_RECRUITING | PHASE4

40 participants

Cladribine Tablets After Treatment With Natalizumab (CLADRINA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-02-19
Completion:: 2026-08-30

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT04168385 | COMPLETED | PHASE2

52 participants

MRX-800: A Long-Term Safety Study of Maralixibat in the Treatment of Cholestatic Liver Disease in Subjects Who Previously Participated in a Maralixibat Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2020-01-16
Completion:: 2024-09-04

Conditions

Cholestatic Liver Disease

Interventions

DRUG

Results Available

NCT04167683 | ACTIVE_NOT_RECRUITING

144 participants

Muscle Dysfunction in Patients With Hematological Diseases Referred to Stem Cell Transplant

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-08
Start Date:: 2023-10-01
Completion:: 2026-11-01

Conditions

Hematologic Diseases
Chronic Myeloid Leukemia
Acute Myeloid Leukemia
Acute Lymphoid Leukemia
Myelodysplastic Syndromes
Non Hodgkin Lymphoma
Stem Cell Transplant Complications
Chronic Lymphocytic Leukemia

Interventions

OTHER

No Results Yet

NCT04100213 | WITHDRAWN | NA

0 participants

Real-Time Assessment of Stress and Stress Response

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2025-12-01
Completion:: 2025-12-01

Conditions

Psychiatric Disorder
Stress Reaction
Stress, Psychological
Stress, Physiological

Interventions

BEHAVIORAL

No Results Yet

NCT03997851 | COMPLETED | PHASE1/PHASE2

17 participants

Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2019-07-22
Completion:: 2020-03-18

Conditions

Pruritus

Interventions

DRUG

Results Available

NCT03968822 | ACTIVE_NOT_RECRUITING | PHASE4

18 participants

Intralipid® 20% for Reversal of Local Anesthetics

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2019-07-26
Completion:: 2026-10-31

Conditions

Anesthesia, Local

Interventions

DRUG
OTHER

No Results Yet

NCT03942978 | COMPLETED | NA

79 participants

Reducing Structural Inequities in Heart Failure Management: An Approach to Improve the Quality of Heart Failure Care on the General Medicine Service: Longitudinal Equity Action Plan (LEAP)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2019-05-31
Completion:: 2020-05-31

Conditions

Heart Failure

Interventions

OTHER

No Results Yet

NCT03899220 | COMPLETED | NA

50 participants

Project Matter: Intervention to Improve HIV Self-care Among Men Who Have Sex With Men (MSM) With Substance Use Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2019-04-24
Completion:: 2023-05-30

Conditions

Substance Use Disorders
HIV/AIDS
Homosexuality, Male

Interventions

BEHAVIORAL

No Results Yet

NCT03886181 | TERMINATED | NA

2 participants

Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal and Superficial Soft Tissue Neoplasia (DaRT)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-07-08
Completion:: 2024-10-13

Conditions

Skin Cancer
Mucosal Neoplasm of Oral Cavity
Soft Tissue Neoplasm

Interventions

DEVICE

No Results Yet

NCT03610997 | TERMINATED | NA

200 participants

Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2001-01-01
Completion:: 2024-09-01

Conditions

Anisometropia
Hyperopia
High Myopia
Amblyopia Isometropic
Amblyopia Bilateral
High Astigmatism

Interventions

PROCEDURE

No Results Yet

NCT03595683 | TERMINATED | PHASE2

8 participants

Pembrolizumab and EDP1503 in Advanced Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2018-10-02
Completion:: 2025-07-31

Conditions

Melanoma (Skin)
Melanoma

Interventions

DRUG
BIOLOGICAL

Results Available

NCT03567876 | COMPLETED | PHASE2

141 participants

Rituximab, Bendamustine and Cytarabine Followed by Venetoclax in High Risk Elderly Patients With MCL

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2018-09-03
Completion:: 2021-07-26

Conditions

Lymphoma, Mantle-Cell

Interventions

DRUG

No Results Yet

NCT03542175 | COMPLETED | PHASE1

31 participants

A Study of Rucaparib Administered With Radiation in Patients With Triple Negative Breast Cancer With an Incomplete Response Following Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2018-05-23
Completion:: 2024-07-25

Conditions

Breast Cancer

Interventions

DRUG
RADIATION

Results Available

NCT03527069 | COMPLETED | PHASE3

146 participants

Efficacy and Safety of Cipros 10 Association on the Isolated Hypertriglyceridemia and Dyslipidemia Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-08
Start Date:: 2021-01-29
Completion:: 2024-08-30

Conditions

Hypertriglyceridemia
Dyslipidemia

Interventions

DRUG

No Results Yet