Clinical Trials Updated in 2025

NCT06194929 | RECRUITING | PHASE1/PHASE2

33 participants

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-03-20
Completion:: 2028-01-15

Conditions

Cutaneous Melanoma
Brain Metastases

Interventions

DRUG

No Results Yet

NCT06193967 | COMPLETED | NA

19 participants

Enhancing Child Dietary Self-monitoring

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-04-04
Completion:: 2024-12-04

Conditions

Nutrition, Healthy

Interventions

BEHAVIORAL

Results Available

NCT06191276 | COMPLETED | NA

40 participants

Combating Hospital-related Function Decline Among Prefrail Older Adults: A Pilot Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-12-01
Completion:: 2023-09-30

Conditions

Frailty
Geriatrics

Interventions

BEHAVIORAL

No Results Yet

NCT06173687 | COMPLETED | NA

51 participants

Multi-center Study to Examine Changes to the Environment Surrounding the Electrodes in the Cochlea and to Capture the Most Challenging Listening Environments Experienced by Persons With a Cochlear Implant

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-01-29
Completion:: 2024-10-24

Conditions

Hearing Loss

Interventions

DEVICE

Results Available

NCT06172205 | RECRUITING | PHASE3

262 participants

Infusional FOLFOX Plus Camrelizumab and Apatinib vs HAIC-FOLFOX Plus Camrelizumab and Apatinib for Advanced HCC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-07-01
Completion:: 2028-07-31

Conditions

BCLC Stage C Hepatocellular Carcinoma
Chemotherapy Effect

Interventions

DRUG

No Results Yet

NCT06170905 | COMPLETED | NA

21 participants

Whey Protein Pre-load and Postprandial Glycemia in Pregnancy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-02-01
Completion:: 2025-04-17

Conditions

Pregnancy
Postprandial Glycemia

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT06159621 | ACTIVE_NOT_RECRUITING | PHASE1

27 participants

CD40 Agonist and PD-1 Inhibitor in HNSCC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-07-02
Completion:: 2028-03-01

Conditions

Head and Neck Squamous Cell Carcinoma

Interventions

DRUG

No Results Yet

NCT06126757 | ACTIVE_NOT_RECRUITING | NA

132 participants

PelviSense, an Innovative, Non-invasive, Biofeedback Device for the Treatment of Stress Urinary Incontinence in Women

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-09-01
Completion:: 2025-12-31

Conditions

Stress Urinary Incontinence

Interventions

DEVICE
OTHER

No Results Yet

NCT06123208 | COMPLETED | NA

36 participants

Impact of Eating Beans on Metabolism

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-10-30
Completion:: 2025-08-15

Conditions

Overweight

Interventions

OTHER

No Results Yet

NCT06090097 | RECRUITING | NA

60 participants

Knee Biofeedback Rehabilitation Through Game Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-09-04
Completion:: 2026-11-01

Conditions

Knee Osteoarthritis

Interventions

DEVICE
OTHER

No Results Yet

NCT06089473 | RECRUITING | NA

30 participants

Virtual Home-based Physical Pre-habilitation in Kidney Transplant Candidates

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-11-02
Completion:: 2026-08-31

Conditions

Kidney Disease, End-Stage
Frailty
Transplant;Failure,Kidney

Interventions

OTHER

No Results Yet

NCT06029244 | COMPLETED | NA

160 participants

Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-02-25
Completion:: 2025-10-20

Conditions

Delirium
Delirium in Old Age
Critical Illness
Intensive Care Unit Delirium

Interventions

DEVICE
OTHER

No Results Yet

NCT06001658 | RECRUITING | PHASE2

27 participants

Perioperative Gemcitabine, Cisplatin, and Pembrolizumab in Potentially Resectable Biliary Tract Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-07-08
Completion:: 2028-06-30

Conditions

Billiary Track Cancer

Interventions

DRUG

No Results Yet

NCT05968066 | COMPLETED

2508 participants

Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-12-01
Completion:: 2025-09-23

Conditions

Fluid Therapy
Vasopressor Therapy
Critical Illness
Invasive Ventilation

No Results Yet

NCT05953129 | COMPLETED

60 participants

Novel Predictors of Post Spinal Hypotension in Cesarean Sections: Evaluating Jugular Vein Collapsibility Index and Shock Indices

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-06-15
Completion:: 2023-10-15

Conditions

Cesarean Section Complications
Regional Anesthesia Morbidity
Hemodynamic Instability
Shock

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05938894 | COMPLETED | NA

630 participants

Train Your Brain - Executive Function

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-09-25
Completion:: 2025-08-18

Conditions

Overweight and Obesity

Interventions

OTHER

No Results Yet

NCT05910216 | COMPLETED | NA

40 participants

Online Dance Versus Therapeutic Exercise for Parkinson Disease.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-10-16
Completion:: 2024-05-30

Conditions

Parkinson Disease

Interventions

OTHER

No Results Yet

NCT05893381 | RECRUITING | PHASE2

70 participants

Lu-PSMA and Stereotactic Radiotherapy Versus Radiotherapy Alone for Prostate Cancer (LUST)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-06-27
Completion:: 2027-09-30

Conditions

Prostate Cancer

Interventions

DRUG
RADIATION

No Results Yet

NCT05869058 | RECRUITING

300 participants

DCNN Developed for Detection and Assessing the Perfusion of PTG

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-06-13
Completion:: 2026-04-30

Conditions

Thyroidectomy

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT05867615 | ACTIVE_NOT_RECRUITING | PHASE2

83 participants

Radiometabolic Therapy With 177Lu PSMA in PSMA PET/CT Positive Advanced/Metastatic Tumours:

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-05-25
Completion:: 2026-08-31

Conditions

Cancer

Interventions

DRUG

No Results Yet

NCT05860699 | RECRUITING | PHASE2

210 participants

Cannabidiol as an add-on Treatment During Inpatient Alcohol Cessation : CBD-OH

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-04-08
Completion:: 2026-05-23

Conditions

Severe Alcohol Use Disorder (DSM 5)

Interventions

DRUG

No Results Yet

NCT05804981 | WITHDRAWN

0 participants

Early Detection of Cognitive Decline

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-06-30
Completion:: 2024-01-19

Conditions

Cognitive Impairment

Interventions

OTHER

No Results Yet

NCT05752474 | COMPLETED | NA

30 participants

Multi-Component Prehabilitation for Major Elective Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-03-27
Completion:: 2025-01-16

Conditions

Frailty
Functional Recovery
Prehabilitation

Interventions

BEHAVIORAL

Results Available

NCT05723263 | COMPLETED | NA

1200 participants

Pay-it-forward Gonorrhea and Chlamydia Testing Among Men in China

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-04-01
Completion:: 2024-07-15

Conditions

Gonorrhea
Chlamydia

Interventions

BEHAVIORAL
OTHER

Results Available

NCT05702463 | RECRUITING | PHASE1

30 participants

Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes II

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-06-13
Completion:: 2027-06-01

Conditions

Platelet Aggregation
Type 2 Diabetes
Aspirin
Diabetes Mellitus, Type 2
Platelet Aggregation Inhibitors

Interventions

DRUG

No Results Yet

NCT05687032 | COMPLETED | PHASE4

44 participants

A Study of Inotuzumab Ozogamicin in Chinese Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-02-24
Completion:: 2024-08-07

Conditions

Acute Lymphoblastic Leukemia

Interventions

DRUG

Results Available

NCT05684198 | COMPLETED | NA

50 participants

NPWT vs Primary Closure in SSI Prevention for Emergency Laparotomies for Peritonitis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-01-11
Completion:: 2025-11-01

Conditions

Peritonitis
Surgical Site Infection
Infections
Wound Infection

Interventions

DEVICE

No Results Yet

NCT05678894 | RECRUITING | NA

140 participants

Single-center Comparative Study of Variation in Acetabular Anteversion According to Pelvic Tilt in Patients With Femoro-acetabular Impingement and Healthy Volunteers.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-09-28
Completion:: 2026-09-30

Conditions

Femoro-acetabular Impingement

Interventions

OTHER

No Results Yet

NCT05669326 | WITHDRAWN | NA

0 participants

Evaluation of the Contribution of NODDI Protocol Tractography in Brain Tumor Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-09-01
Completion:: 2025-09-01

Conditions

Malignant Brain Tumor

Interventions

OTHER

No Results Yet

NCT05667987 | RECRUITING | NA

1800 participants

Evaluation of the Benefit of Lidocaine on the Prevention of the Risk of Post Endoscopic Retrograde Cholangio-pancreatography Pancreatitis.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2024-01-18
Completion:: 2026-01-18

Conditions

ERCP Surgery

Interventions

DRUG

No Results Yet

NCT05660109 | COMPLETED | PHASE2

28 participants

A Study to Assess the Safety of TPM502 in Adults With Celiac Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-12-12
Completion:: 2024-07-04

Conditions

Celiac Disease

Interventions

DRUG
OTHER

No Results Yet

NCT05644951 | COMPLETED | NA

51 participants

Clinical Trial of EPASS With Hot AXIOS System

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-12-23
Completion:: 2024-12-05

Conditions

Gastric Outlet Obstruction

Interventions

DEVICE

No Results Yet

NCT05628285 | COMPLETED | NA

11 participants

Evaluation of a Hearing Device for Transmitting Sound to the Inner Ear

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-11-15
Completion:: 2023-04-25

Conditions

Conductive Hearing Loss
Mixed Hearing Loss

Interventions

DEVICE

Results Available

NCT05626634 | COMPLETED | PHASE2

41 participants

Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-11-08
Completion:: 2024-12-20

Conditions

Developmental and Epileptic Encephalopathy
Dravet Syndrome
Lennox-Gastaut Syndrome

Interventions

DRUG

No Results Yet

NCT05621148 | COMPLETED

152 participants

REfractorinesS to Ibrutinib BTKi and Systemic Targeted Therapy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-01-25
Completion:: 2023-12-31

Conditions

CLL, Relapsed
CLL, Refractory
Bruton Tyrosine Kinase Inhibitor
Small Lymphocytic Leukemia

No Results Yet

NCT05617677 | ACTIVE_NOT_RECRUITING | PHASE3

516 participants

A Study to Assess Effectiveness and Safety of Deucravacitinib Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-01-12
Completion:: 2026-10-19

Conditions

Systemic Lupus Erythematosus

Interventions

DRUG
OTHER

No Results Yet

NCT05598333 | ACTIVE_NOT_RECRUITING | PHASE2

150 participants

Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-10-20
Completion:: 2026-10-31

Conditions

Congestive Heart Failure

Interventions

DRUG

No Results Yet

NCT05590702 | ACTIVE_NOT_RECRUITING

1000 participants

French Observational Study of Patients With Chronic Lymphocytic Leukemia Or Small Lymphocytic Lymphoma in Real-World Settings

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2022-11-11
Completion:: 2025-04-18

Conditions

CLL/SLL

Interventions

DRUG

No Results Yet

NCT05574855 | COMPLETED

113 participants

Evaluation of Haemodynamic in Neonates Treated With Hypothermia"

Study Type:: OBSERVATIONAL
Last Updated:: 2025-12-03
Start Date:: 2021-08-01
Completion:: 2024-02-16

Conditions

Hypothermia Neonatal
Haemodynamic Instability
Perinatal Asphyxia

No Results Yet

NCT05564637 | COMPLETED | PHASE2

29 participants

A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2025-12-03
Start Date:: 2023-03-13
Completion:: 2024-10-30

Conditions

Pulmonary Arterial Hypertension
Interstitial Lung Disease
Healthy Adults

Interventions

DRUG
DIAGNOSTIC_TEST

Results Available