Clinical Trials Updated in 2025

NCT04522167 | COMPLETED | PHASE3

434 participants

Efficacy and Safety of the Aflibercept FYB203 Biosimilar in Comparison to Eylea® in Patients With Neovascular Age-Related Macular Degeneration

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2020-07-21
Completion:: 2022-06-23

Conditions

Neovascular Age-related Macular Degeneration

Interventions

DRUG

Results Available

NCT04515784 | COMPLETED | NA

45 participants

Safety Aid Reduction Treatment for PTSD Among Veterans

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2024-09-23
Completion:: 2025-09-29

Conditions

Stress Disorders, Post-Traumatic

Interventions

BEHAVIORAL

No Results Yet

NCT04453033 | ACTIVE_NOT_RECRUITING | NA

350 participants

DB RCT for Specialized Phototherapy in Parkinson's Disease.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2024-02-26
Completion:: 2026-06-30

Conditions

Parkinson Disease

Interventions

DEVICE

No Results Yet

NCT04419779 | SUSPENDED | NA

320 participants

Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2021-03-08
Completion:: 2026-01-31

Conditions

Type 2 Diabetes

Interventions

DEVICE

No Results Yet

NCT04417257 | TERMINATED | PHASE2/PHASE3

351 participants

Study of LAU-7b for the Treatment of Coronavirus Disease 2019 (COVID-19) Disease in Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2020-08-18
Completion:: 2024-02-15

Conditions

COVID-19 Disease

Interventions

DRUG

Results Available

NCT04312932 | COMPLETED | PHASE2

98 participants

Fatty Acid Supplementation in Children With ASD (Study 2)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2021-12-01
Completion:: 2023-11-28

Conditions

Autism Spectrum Disorder

Interventions

DRUG
DIETARY_SUPPLEMENT

Results Available

NCT04188509 | TERMINATED | PHASE3

162 participants

Open-Label Extension of Voxelotor

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2019-11-18
Completion:: 2024-11-01

Conditions

Sickle Cell Disease

Interventions

DRUG

Results Available

NCT04139499 | COMPLETED

18 participants

Use of High-resolution Manometry to Detect Upper Airway Obstruction During Sleep

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-13
Start Date:: 2019-01-16
Completion:: 2021-05-05

Conditions

Obstructive Sleep Apnea

Interventions

PROCEDURE

No Results Yet

NCT04116671 | ACTIVE_NOT_RECRUITING | NA

5 participants

Stimulation Combined With Powered Motorized Orthoses for Walking After Stroke

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2020-04-01
Completion:: 2026-11-01

Conditions

Stroke
Hemiparesis

Interventions

DEVICE

No Results Yet

NCT04115254 | RECRUITING | NA

397 participants

Stereotactic Magnetic Resonance Guided Radiation Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2019-10-22
Completion:: 2028-06-30

Conditions

Pancreas Cancer
Lung Cancer
Renal Cancer
Adrenal Metastases
Prostate Cancer
Liver Metastases
Oligoprogressive Nodal Metastases
Metachronous Nodal Metastases
Synchronous Nodal Metastases
Mesothelioma
Spine Metastases
Brain Metastases
Borderline Resectable Pancreatic Carcinoma

Interventions

RADIATION

No Results Yet

NCT04105868 | COMPLETED | NA

15 participants

Adolescent Attention to Emotion Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2019-10-16
Completion:: 2024-09-23

Conditions

Depression

Interventions

OTHER

Results Available

NCT04024436 | TERMINATED | PHASE2

64 participants

A Study of TAS-120 in Patients With Metastatic Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2020-01-28
Completion:: 2023-05-31

Conditions

Metastatic Breast Cancer
FGFR 1 High Amplification
FGFR2 Amplification

Interventions

DRUG

Results Available

NCT03797183 | RECRUITING

90 participants

Genesis Electrical Impedance Tomography (EIT): A Preliminary Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-13
Start Date:: 2019-05-03
Completion:: 2026-11-30

Conditions

Premature Infant
Chronic Respiratory Disease
Neuromuscular Diseases
Healthy
Bronchopulmonary Dysplasia
Pulmonary Vein Stenoses

No Results Yet

NCT03787290 | SUSPENDED | PHASE2

35 participants

Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2026-12-01
Completion:: 2028-12-01

Conditions

Major Depressive Disorder

Interventions

DRUG
DEVICE

No Results Yet

NCT03718325 | TERMINATED | NA

12 participants

Burst Spinal Cord Stimulation (Burst-SCS) Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2019-03-12
Completion:: 2020-03-10

Conditions

Pain, Chronic
Failed Back Surgery Syndrome

Interventions

DEVICE

Results Available

NCT03670355 | COMPLETED | PHASE1

49 participants

Pharmacokinetic and Safety Study of a 90 Day Intravaginal Ring Containing Tenofovir

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2019-01-02
Completion:: 2019-09-25

Conditions

HIV Infections

Interventions

DRUG

Results Available

NCT03623958 | RECRUITING | NA

200 participants

Image Guided VATS vs. VATS Resection

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2018-09-11
Completion:: 2027-07-31

Conditions

Lung Cancer

Interventions

DEVICE
PROCEDURE

No Results Yet

NCT03525951 | COMPLETED | NA

156 participants

Parent-Level Predictors of Early Language Interaction Quality and Intervention Outcomes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2021-03-22
Completion:: 2025-09-18

Conditions

Language Development Disorders
Autism Spectrum Disorder

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT03517436 | ACTIVE_NOT_RECRUITING | NA

101 participants

ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2018-09-18
Completion:: 2020-10-02

Conditions

Aortic Valve Stenosis

Interventions

DEVICE

Results Available

NCT03107780 | TERMINATED | PHASE1

32 participants

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2018-07-09
Completion:: 2025-08-15

Conditions

Glioblastoma
Gliosarcoma
MGMT-Unmethylated Glioblastoma
Recurrent Glioblastoma

Interventions

PROCEDURE
DRUG
RADIATION

No Results Yet

NCT02661997 | COMPLETED | NA

114 participants

Novel Interventions for GWVI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2017-06-01
Completion:: 2023-09-29

Conditions

Gulf War Veteran's Illness

Interventions

BEHAVIORAL

Results Available

NCT02270567 | ENROLLING_BY_INVITATION

400 participants

RegisterNET - A Registry for Neuroendocrine Tumors in the USA and Worldwide

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-13
Start Date:: 2015-02-28
Completion:: 2018-03-31

Conditions

Neuroendocrine Tumor
Carcinoid
Neuroendocrine Carcinoma

Interventions

DEVICE

No Results Yet

NCT01969344 | ACTIVE_NOT_RECRUITING

2981 participants

Study of COPD Subgroups and Biomarkers

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-13
Start Date:: 2010-11-30
Completion:: 2031-06-17

Conditions

COPD
Chronic Obstructive Pulmonary Disease
Chronic Bronchitis
Emphysema

No Results Yet

NCT01878617 | ACTIVE_NOT_RECRUITING | PHASE2

660 participants

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-13
Start Date:: 2013-06-23
Completion:: 2028-10-13

Conditions

Medulloblastoma

Interventions

RADIATION
DRUG
OTHER

No Results Yet

NCT01018537 | RECRUITING

50000 participants

NARCOMS Registry: A Multiple Sclerosis Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-13
Start Date:: 1996-01-31
Completion:: 2050-12-31

Conditions

Multiple Sclerosis

No Results Yet

NCT07227545 | NOT_YET_RECRUITING | NA

18 participants

High Intensity Alternating Current Stimulation as a Neuromodulation Therapy for Alcohol Use Disorder: A Pilot Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-12-01
Completion:: 2026-11-30

Conditions

Alcohol Use Disorder (AUD)

Interventions

DEVICE

No Results Yet

NCT07227493 | RECRUITING

45 participants

Open Pilon With FIBERGRAFT AERIDYAN Matrix Bioactive Glass

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-10-24
Completion:: 2027-01-31

Conditions

Open Pilon Fractures

Interventions

DEVICE

No Results Yet

NCT07227324 | RECRUITING

1000 participants

Cannabis Use Registry to Improve Overall Understanding of Symptoms (CURIOUS)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-08-26
Completion:: 2027-04-30

Conditions

Cannabis Use
Cancer

No Results Yet

NCT07227285 | NOT_YET_RECRUITING | PHASE1/PHASE2

16 participants

Long-term Follow-up Study of Patients Who Received EG110A, a Non-replicative Herpes Simplex Virus 1-derived Gene Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2026-04-30
Completion:: 2031-04-30

Conditions

Urinary Bladder, Overactive
Spinal Cord Injury

Interventions

OTHER
DRUG

No Results Yet

NCT07227194 | COMPLETED

53065 participants

Machine Learning Assessment of Next-Day Migraine Likelihood

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-02-07
Completion:: 2025-08-01

Conditions

Migraine

No Results Yet

NCT07227116 | RECRUITING

280 participants

Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-11-01
Completion:: 2026-04-30

Conditions

Complex Aneuploidy
Chaotic Aneuploidy

No Results Yet

NCT07226973 | RECRUITING | NA

48 participants

Gait After THA: Direct Anterior vs Manual Posterior vs Robotic Posterior

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-10-09
Completion:: 2027-11-15

Conditions

Osteoarthritis (OA) of the Hip

Interventions

PROCEDURE

No Results Yet

NCT07226921 | RECRUITING | NA

360 participants

Language Control Across Modalities

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-08-06
Completion:: 2030-05-31

Conditions

Healthy

Interventions

BEHAVIORAL

No Results Yet

NCT07226908 | ENROLLING_BY_INVITATION | NA

100 participants

Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2024-09-01
Completion:: 2029-08-31

Conditions

Epilepsy

Interventions

OTHER

No Results Yet

NCT07226830 | NOT_YET_RECRUITING

25 participants

Quantification of Change in MG Disease Activity in Individuals With Generalized Myasthenia Gravis (gMG) After Administration of VYVGART® or VYVGART Hytrulo® Using BioDigit MG

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2026-01-15
Completion:: 2028-01-31

Conditions

Myasthenia Gravis Generalized

No Results Yet

NCT07205120 | RECRUITING | NA

50 participants

Fluid Guided Heart Failure Treatment at the Cleveland Clinic

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-10-08
Completion:: 2026-03-31

Conditions

Heart Failure

Interventions

DEVICE

No Results Yet

NCT07204444 | COMPLETED | NA

671 participants

The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-06-01
Completion:: 2024-10-25

Conditions

Older Adults
Mental Health
Depression
Loneliness
Social Isolation
Suicide Ideations
Social Functioning
Quality of Life
Thwarted Belongingness
Perceived Burdensomeness
Help-Seeking Behavior
Suicide Risk

Interventions

BEHAVIORAL

Results Available

NCT07197216 | ENROLLING_BY_INVITATION | NA

100 participants

Evaluation of the Tap Trust Intervention on Water Security Experiences and Beverage Intake

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-11-07
Completion:: 2027-07-31

Conditions

Beverage Intake
Child Health and Nutrition

Interventions

BEHAVIORAL

No Results Yet

NCT07158333 | COMPLETED

15 participants

Mobile Cardiac Telemetry (MCT) Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-08-05
Completion:: 2025-09-12

Conditions

Healthy

Interventions

DEVICE

No Results Yet

NCT07155317 | RECRUITING | PHASE2

99 participants

Time-of-Day Specified Immunotherapy for Advanced Melanoma, The TIME Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2025-10-29
Completion:: 2026-12-31

Conditions

Advanced Acral Melanoma
Advanced Cutaneous Melanoma
Advanced Mucosal Melanoma
Clinical Stage IV Cutaneous Melanoma AJCC v8
Metastatic Acral Melanoma
Metastatic Cutaneous Melanoma
Metastatic Mucosal Melanoma
Unresectable Acral Melanoma
Unresectable Cutaneous Melanoma
Unresectable Mucosal Melanoma

Interventions

PROCEDURE
BIOLOGICAL
OTHER

No Results Yet