Clinical Trials Updated in 2025

NCT04840394 | COMPLETED | PHASE1

1 participants

Clinical Study of BDB018: Monotherapy and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-06-22
Completion:: 2024-03-31

Conditions

Tumor, Solid

Interventions

DRUG

No Results Yet

NCT04819373 | COMPLETED | PHASE2

1 participants

BDB001-201: A Clinical Study of BDB001 in Patients With PD-(L)1 Refractory Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-08-30
Completion:: 2023-04-01

Conditions

Tumor, Solid

Interventions

DRUG

No Results Yet

NCT04779177 | COMPLETED | PHASE1

26 participants

Safety, Tolerability, and Pharmacokinetics of Lumateperone in Pediatric Patients With Schizophrenia or Schizoaffective Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-03-12
Completion:: 2022-07-30

Conditions

Schizophrenia
Pediatric

Interventions

DRUG

Results Available

NCT04657146 | SUSPENDED

40 participants

Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2024-02-05
Completion:: 2027-11-01

Conditions

Glioblastoma

Interventions

OTHER

No Results Yet

NCT04647487 | COMPLETED | PHASE1

87 participants

A Study of LY3484356 in Women With Breast Cancer Before Having Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-04-21
Completion:: 2022-11-11

Conditions

Breast Cancer

Interventions

DRUG

Results Available

NCT04622332 | COMPLETED | PHASE1

45 participants

A Pilot Study to Assess Safety and Efficacy of SIR1-365 in Patients With Severe COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-12-18
Completion:: 2021-11-27

Conditions

Corona Virus Infection

Interventions

DRUG

Results Available

NCT04551430 | ACTIVE_NOT_RECRUITING | PHASE2

105 participants

Cabozantinib Combined With PD-1 and CTLA-4 Inhibition in Metastatic Soft Tissue Sarcoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-01-05
Completion:: 2027-02-01

Conditions

Metastatic Soft-tissue Sarcoma

Interventions

DRUG

No Results Yet

NCT04514861 | ACTIVE_NOT_RECRUITING | NA

53 participants

Monitoring Local Tissue Oxygen Changes Using the Wireless Lumee Oxygen Platform in Correlation to TcPO2

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-12-18
Completion:: 2027-03-30

Conditions

Peripheral Artery Disease

Interventions

DEVICE

No Results Yet

NCT04477512 | COMPLETED | PHASE1

18 participants

Cabozantinib and Abiraterone With Checkpoint Inhibitor Immunotherapy in Metastatic Hormone Sensitive Prostate Cancer (CABIOS Trial)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-02-19
Completion:: 2021-09-09

Conditions

Metastatic Hormone Refractory Prostate Cancer

Interventions

DRUG
PROCEDURE

No Results Yet

NCT04440228 | COMPLETED | NA

90 participants

TeamSTEPPS in School Mental Health

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2022-05-23
Completion:: 2024-04-30

Conditions

Child Behavior Problem
Multidisciplinary Communication
Interprofessional Relations

Interventions

BEHAVIORAL

Results Available

NCT04415515 | TERMINATED | NA

592023 participants

Standard Care Coordination Expansion Pilot

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2015-10-31
Completion:: 2023-12-31

Conditions

Superutilizers, Health Care Utilization

Interventions

BEHAVIORAL

No Results Yet

NCT04384172 | COMPLETED | NA

9 participants

Effect of Peripheral Neuromodulation on Vaginal Blood Flow

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-11-11
Completion:: 2022-03-15

Conditions

Female Sexual Dysfunction
Spinal Cord Injuries

Interventions

DEVICE

Results Available

NCT04375072 | COMPLETED | NA

208 participants

Home-based tDCS and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-08-13
Completion:: 2025-01-30

Conditions

Osteo Arthritis Knee

Interventions

DEVICE

Results Available

NCT04272086 | COMPLETED | PHASE4

140 participants

Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-11-09
Completion:: 2025-10-28

Conditions

Fibroid Uterus

Interventions

DRUG

No Results Yet

NCT04228367 | RECRUITING | NA

104 participants

JuggerStitch Post Market Clinical Follow-up Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-09-25
Completion:: 2026-03-31

Conditions

Meniscus Tear, Tibial
Meniscus Lesion

Interventions

DEVICE

No Results Yet

NCT04204616 | ACTIVE_NOT_RECRUITING | PHASE3

500 participants

A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-01-11
Completion:: 2026-10-26

Conditions

Prurigo Nodularis

Interventions

DRUG

No Results Yet

NCT04196530 | COMPLETED | PHASE1

40 participants

BDB001-102: Open Label Dose Escalation of BDB001 in Combination w Atezolizumab

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-11-21
Completion:: 2024-07-31

Conditions

Tumor, Solid

Interventions

DRUG

No Results Yet

NCT04150614 | RECRUITING | PHASE4

90 participants

BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to Ondansetron

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-05-14
Completion:: 2026-07-31

Conditions

Nausea With Vomiting Chemotherapy-Induced

Interventions

DRUG

No Results Yet

NCT04122196 | COMPLETED | PHASE2/PHASE3

118 participants

Perioperative Pregabalin in Ureteroscopy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-06-01
Completion:: 2023-07-01

Conditions

Kidney Stone
Pain, Postoperative
Addiction
Opioid Use

Interventions

DRUG

Results Available

NCT03979508 | TERMINATED | PHASE2

26 participants

Abemaciclib in Treating Patients With Surgically Resectable, Chemotherapy Resistant, Triple Negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2020-01-10
Completion:: 2024-12-26

Conditions

Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage III Breast Cancer AJCC v8
Breast Ductal Carcinoma In Situ
Breast Fibrocystic Change
Breast Lobular Carcinoma In Situ
Invasive Breast Carcinoma
Prognostic Stage I Breast Cancer AJCC v8
Prognostic Stage IA Breast Cancer AJCC v8
Prognostic Stage IB Breast Cancer AJCC v8
Prognostic Stage II Breast Cancer AJCC v8
Prognostic Stage IIA Breast Cancer AJCC v8
Prognostic Stage IIB Breast Cancer AJCC v8
Prognostic Stage III Breast Cancer AJCC v8
Prognostic Stage IIIA Breast Cancer AJCC v8
Prognostic Stage IIIB Breast Cancer AJCC v8
Prognostic Stage IIIC Breast Cancer AJCC v8
Triple-Negative Breast Carcinoma

Interventions

DRUG
PROCEDURE

No Results Yet

NCT03970603 | COMPLETED | NA

40 participants

Syndesmosis Ankle Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-10-15
Completion:: 2023-10-26

Conditions

Syndesmotic Disruption
Weight-bearing Status

Interventions

OTHER

No Results Yet

NCT03950817 | COMPLETED | PHASE4

80 participants

Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-05-13
Completion:: 2024-09-24

Conditions

Pain

Interventions

DRUG

Results Available

NCT03916419 | COMPLETED | PHASE2

26 participants

Magnetic Resonance-Guided Hypofractionated Adaptive Radiation Therapy With Concurrent Chemotherapy and Consolidation Durvalumab for Inoperable Stage IIB, IIIA, and Select IIIB and IIIC Non-small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-06-20
Completion:: 2025-09-28

Conditions

Stage IIB Non-Small Cell Lung Cancer
Stage IIIA Non-small Cell Lung Cancer
Stage IIIB Non-small Cell Lung Cancer
Stage IIIC Non-Small Cell Lung Cancer

Interventions

DEVICE
RADIATION
DRUG
BIOLOGICAL

No Results Yet

NCT03911557 | COMPLETED | PHASE2

14 participants

Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-06-08
Completion:: 2025-10-10

Conditions

Tumor, Solid

Interventions

DRUG

No Results Yet

NCT03893318 | TERMINATED | PHASE4

15 participants

IV Lidocaine in Pediatric AIS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-07-30
Completion:: 2024-12-31

Conditions

Systemic Lidocaine Improves Pain Control After Surgery by Attenuating the Systemic Inflammatory Response to Surgery

Interventions

DRUG

Results Available

NCT03846830 | COMPLETED | NA

24 participants

Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2021-10-11
Completion:: 2025-04-01

Conditions

Mild Traumatic Brain Injury
Vestibular Neuropathy

Interventions

BEHAVIORAL
DEVICE

No Results Yet

NCT03838627 | COMPLETED

34 participants

Feasibility and Agreement of Remote Evaluation of Resting Heart Rate and Heart Rate Variability in Survivors of Hodgkin Lymphoma Treated With Chest Radiation (PILOT STUDY-SURVIVOR)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-02-05
Completion:: 2021-01-19

Conditions

Hodgkin Disease

No Results Yet

NCT03758638 | COMPLETED | PHASE3

620 participants

Healthy Eating and Active Living Taught at Home (HEALTH) Dissemination & Implementation (D&I)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-01-25
Completion:: 2024-07-31

Conditions

Obesity

Interventions

BEHAVIORAL

Results Available

NCT03738228 | COMPLETED | PHASE1

40 participants

Atezolizumab Before and/or With Chemoradiotherapy in Immune System Activation in Patients With Node Positive Stage IB2, II, IIIB, or IVA Cervical Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-01-07
Completion:: 2022-05-01

Conditions

Cervical Adenocarcinoma
Cervical Adenosquamous Carcinoma
Cervical Squamous Cell Carcinoma
Stage IB2 Cervical Cancer AJCC v8
Stage II Cervical Cancer AJCC v8
Stage IIA Cervical Cancer AJCC v8
Stage IIA1 Cervical Cancer AJCC v8
Stage IIA2 Cervical Cancer AJCC v8
Stage IIB Cervical Cancer AJCC v8
Stage IIIB Cervical Cancer AJCC v8
Stage IVA Cervical Cancer AJCC v8

Interventions

DRUG
RADIATION

Results Available

NCT03723564 | RECRUITING | PHASE1

40 participants

Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-10-01
Completion:: 2026-12-31

Conditions

Renal Failure Congenital
Congenital Renal Anomaly Nos
Renal Agenesis and Dysgenesis
Lower Urinary Tract Obstructive Syndrome

Interventions

DRUG

No Results Yet

NCT03656718 | COMPLETED | PHASE1/PHASE2

139 participants

A Study of Subcutaneous Nivolumab Monotherapy With or Without Recombinant Human Hyaluronidase PH20 (rHuPH20)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-10-29
Completion:: 2022-09-07

Conditions

Neoplasms by Site

Interventions

BIOLOGICAL
DRUG

Results Available

NCT03599245 | COMPLETED | PHASE3

1055 participants

This is an Extension Study of the Roche P-trials to Investigate Safety and Effectiveness of Ocrelizumab in Participants With Multiple Sclerosis (MS)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-07-12
Completion:: 2025-07-17

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT03582475 | ACTIVE_NOT_RECRUITING | PHASE1

15 participants

Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2019-01-11
Completion:: 2025-12-01

Conditions

Bladder Small Cell Neuroendocrine Carcinoma
Castration-Resistant Prostate Carcinoma
Metastatic Bladder Urothelial Carcinoma
Metastatic Urethral Urothelial Carcinoma
Prostate Carcinoma Metastatic in the Bone
Prostate Neuroendocrine Neoplasm
Prostate Small Cell Carcinoma
Stage III Bladder Cancer American Joint Committee on Cancer ( AJCC) v8
Stage III Prostate Cancer AJCC v8
Stage III Urethral Cancer AJCC v8
Stage IV Bladder Cancer AJCC v8
Stage IV Prostate Cancer AJCC v8
Stage IV Urethral Cancer AJCC v8
Stage IVA Bladder Cancer AJCC v8
Stage IVB Bladder Cancer AJCC v8
Ureter Small Cell Carcinoma
Urothelial Carcinoma

Interventions

DRUG
BIOLOGICAL

Results Available

NCT03579901 | ACTIVE_NOT_RECRUITING | NA

800 participants

Study of the Safety and Effectiveness of Motiva Implants®

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-04-06
Completion:: 2032-08-30

Conditions

Breast Implants

Interventions

DEVICE

No Results Yet

NCT03498612 | TERMINATED | PHASE2

9 participants

Pembrolizumab in Untreated B-Cell Non-Hodgkin Lymphoproliferative Diseases

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-07-09
Completion:: 2021-06-09

Conditions

Follicular Lymphoma
Indolent B-Cell Non-Hodgkin Lymphoma
Marginal Zone Lymphoma

Interventions

OTHER
BIOLOGICAL

Results Available

NCT03486301 | COMPLETED | PHASE1

87 participants

BDB001-101: Clinical Study of BDB001 as a Mono-therapy or in Combination With Pembrolizumab

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-02-15
Completion:: 2024-03-31

Conditions

Tumor, Solid

Interventions

DRUG

No Results Yet

NCT03431064 | RECRUITING

48 participants

Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-06-21
Completion:: 2027-12-31

Conditions

Anesthesia
Intravenous Fluid
Blood Pressure

Interventions

OTHER

No Results Yet

NCT03371017 | COMPLETED | PHASE3

595 participants

A Study of the Efficacy and Safety of Atezolizumab Plus Chemotherapy for Patients With Early Relapsing Recurrent Triple-Negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-01-11
Completion:: 2024-10-23

Conditions

Triple Negative Breast Neoplasms

Interventions

DRUG

Results Available

NCT03150511 | RECRUITING | PHASE2

36 participants

Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2018-06-01
Completion:: 2027-12-31

Conditions

Peripheral Nerve Injuries

Interventions

DRUG

No Results Yet

NCT03021993 | COMPLETED | PHASE2

17 participants

Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-11-12
Start Date:: 2017-05-30
Completion:: 2021-11-15

Conditions

Oral Cavity SCC

Interventions

DRUG

Results Available