Clinical Trials Updated in 2025

NCT05656534 | COMPLETED | EARLY_PHASE1

81 participants

Orexin Receptor Antagonists as Modulators of Threat Sensitivity in Individuals With Alcohol Use Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-11-29
Completion:: 2024-08-01

Conditions

Alcohol Use Disorder

Interventions

DRUG
OTHER

Results Available

NCT05634512 | ACTIVE_NOT_RECRUITING

13 participants

Evaluation of Intravenous Laronidase Pharmacokinetics Before and After Hematopoietic Cell Transplantation in Patients With Mucopolysaccharidosis Type IH.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-11-17
Completion:: 2025-10-28

Conditions

Hematopoietic Cell Transplantation
Mucopolysaccharidosis Type I

Interventions

DRUG

No Results Yet

NCT05630924 | TERMINATED | NA

1294 participants

Children's Lifestyle, Diet, and Exercise Intervention - CHILDREN's Project

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-12-01
Completion:: 2024-12-15

Conditions

Healthy Lifestyle
Cardiovascular Health

Interventions

OTHER

No Results Yet

NCT05625802 | COMPLETED | PHASE2

5 participants

Erector Spinae Plane Block for Uncomplicated Renal Colic

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2023-02-08
Completion:: 2024-01-03

Conditions

Renal Colic
Kidney Stone

Interventions

PROCEDURE
DRUG

Results Available

NCT05593549 | RECRUITING | EARLY_PHASE1

60 participants

Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2023-01-01
Completion:: 2028-12-31

Conditions

Type 2 Diabetes
Healthy Aging

Interventions

DRUG

No Results Yet

NCT05546099 | RECRUITING | PHASE3

160 participants

Patient-driven Management of BP in CKD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-12-15
Completion:: 2026-09-30

Conditions

Chronic Kidney Disease

Interventions

BEHAVIORAL

No Results Yet

NCT05515536 | ACTIVE_NOT_RECRUITING | PHASE3

130 participants

A Study to Assess the Safety and Efficacy of Vatiquinone in Participants With Friedreich Ataxia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-12-08
Completion:: 2027-12-31

Conditions

Friedreich Ataxia

Interventions

DRUG

No Results Yet

NCT05416983 | COMPLETED

37 participants

Developing a Shared Decision Making Tool for Patients With Surgically Removed Non-small Cell Lung Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-02-17
Completion:: 2023-08-31

Conditions

Lung Non-Small Cell Carcinoma

Interventions

PROCEDURE
OTHER

No Results Yet

NCT05336695 | RECRUITING | PHASE1/PHASE2

30 participants

Assess Fibrin in Brains With AD/ADRD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-03-29
Completion:: 2026-09-28

Conditions

Alzheimer Disease
Dementia of Alzheimer Type

Interventions

DIAGNOSTIC_TEST
DRUG

No Results Yet

NCT05336630 | COMPLETED | NA

152 participants

Study of Forceps Cannulation During ERCP

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-05-12
Completion:: 2024-10-15

Conditions

Post-ERCP Acute Pancreatitis

Interventions

DEVICE

Results Available

NCT05300451 | ENROLLING_BY_INVITATION | PHASE2

10 participants

Daratumumab in HLA Desensitization Prior to Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-03-31
Completion:: 2026-08-31

Conditions

Cardiac Transplant

Interventions

BIOLOGICAL

No Results Yet

NCT05271370 | TERMINATED | PHASE2/PHASE3

56 participants

An Extension Protocol for Virologically Suppressed Subjects Who Successfully Completed PRO140_CD03 Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2017-08-29
Completion:: 2022-06-20

Conditions

HIV-1-infection

Interventions

DRUG

Results Available

NCT05236764 | ACTIVE_NOT_RECRUITING | NA

3 participants

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2023-12-06
Completion:: 2024-08-29

Conditions

Acute Lymphoblastic Leukemia in Remission
Acute Myeloid Leukemia in Remission
Myelodysplastic Syndromes
Chronic Myeloid Leukemia
Hemophagocytic Lymphohistiocytoses
Primary Immunodeficiency Diseases
Hemoglobinopathies
Severe Aplastic Anemia
Cytopenia
Bone Marrow Failure Syndrome
Severe Chronic Active Epstein-Barr Virus Infection

Interventions

DEVICE

Results Available

NCT05211986 | RECRUITING | PHASE1/PHASE2

28 participants

Safety and Tolerability of IMM01-STEM in Patients With Muscle Atrophy Related to Knee Osteoarthritis.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-09-13
Completion:: 2026-03-30

Conditions

Muscle Atrophy

Interventions

DRUG

No Results Yet

NCT05096403 | COMPLETED | PHASE3

24 participants

A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients With Cold Agglutinin Disease (CAD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-10-20
Completion:: 2024-05-27

Conditions

Cold Agglutinin Disease

Interventions

DRUG

Results Available

NCT05047068 | ACTIVE_NOT_RECRUITING

350 participants

OCS Heart Perfusion Post-Approval Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-09-13
Completion:: 2025-12-31

Conditions

Transplant

Interventions

DEVICE

No Results Yet

NCT05031897 | RECRUITING | PHASE2

63 participants

Two Step Haplo With Radiation Conditioning

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-10-25
Completion:: 2032-04-30

Conditions

Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
Adult T-Cell Leukemia/Lymphoma
Aplastic Anemia
Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia, BCR-ABL1 Positive
Chronic Myelomonocytic Leukemia
Essential Thrombocythemia
Hematopoietic and Lymphatic System Neoplasm
Hodgkin Lymphoma
Multiple Myeloma
Myelodysplastic Syndrome
Myelofibrosis
Myeloid Neoplasm
Non-Hodgkin Lymphoma
Polycythemia Vera
Small Lymphocytic Lymphoma

Interventions

DRUG
RADIATION
PROCEDURE

No Results Yet

NCT05018208 | COMPLETED

100 participants

Remote Monitoring in Cancer Care: A Platform Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-12-15
Completion:: 2025-04-17

Conditions

Head and Neck Carcinoma
Hematopoietic and Lymphoid Cell Neoplasm
Lung Carcinoma
Malignant Digestive System Neoplasm
Malignant Solid Neoplasm

Interventions

OTHER
PROCEDURE

No Results Yet

NCT05008874 | TERMINATED

65 participants

Study of Disease Progression in Adults With Inherited Forms of Spastic Paraplegia

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-06-21
Completion:: 2025-05-16

Conditions

AMN
AMN Gene Mutation
X-ALD

Interventions

OTHER

No Results Yet

NCT04972110 | TERMINATED | PHASE1/PHASE2

156 participants

Study of RP-3500 (Camonsertib) With Niraparib or Olaparib in Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-07-21
Completion:: 2024-11-13

Conditions

Advanced Solid Tumor, Adult

Interventions

DRUG

Results Available

NCT04946656 | COMPLETED | NA

3 participants

A Study of SPG Block for Opioid Withdrawal

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2023-02-03
Completion:: 2025-09-03

Conditions

Opioid Use Disorder

Interventions

PROCEDURE

No Results Yet

NCT04923880 | COMPLETED | NA

643 participants

Pragmatic Implementation Trial of a CF Primary Palliative Care Intervention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-06-25
Completion:: 2025-06-30

Conditions

Cystic Fibrosis
Quality of Life

Interventions

OTHER

No Results Yet

NCT04892706 | COMPLETED | PHASE2

686 participants

Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-06-11
Completion:: 2022-09-28

Conditions

Acne Vulgaris

Interventions

DRUG

Results Available

NCT04828798 | RECRUITING | NA

24 participants

Directional Versus Nondirectional DBS for ET

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-04-01
Completion:: 2027-10-01

Conditions

Essential Tremor

Interventions

DEVICE

No Results Yet

NCT04805957 | ENROLLING_BY_INVITATION | NA

10 participants

Validation Digital Bio-markers During Sulforaphane Treatment.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-07-07
Completion:: 2026-12-01

Conditions

Autism
Autism Spectrum Disorder
Autistic Disorder

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04787991 | COMPLETED | PHASE1

45 participants

Exploratory Platform Trial to Evaluate Immunotherapy Combinations With Chemotherapy for the Treatment of Patients With Previously Untreated Metastatic Pancreatic Adenocarcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-08-09
Completion:: 2024-11-12

Conditions

Metastatic Pancreatic Adenocarcinoma

Interventions

DRUG

No Results Yet

NCT04704050 | TERMINATED | PHASE4

22 participants

Effect of Dronedarone on Atrial Fibrosis Progression and Atrial Fibrillation Recurrence

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-05-15
Completion:: 2022-12-20

Conditions

Atrial Fibrillation
Atrial Fibrillation Recurrent

Interventions

DRUG

Results Available

NCT04586244 | TERMINATED | PHASE2

30 participants

An Umbrella Study to Determine the Safety and Efficacy of Various Monotherapy or Combination Therapies in Neoadjuvant Urothelial Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2022-01-14
Completion:: 2024-01-29

Conditions

Urothelial Carcinoma

Interventions

DRUG

Results Available

NCT04545489 | COMPLETED | NA

305 participants

A Nurse-led Intervention to Extend the Veteran HIV Treatment Cascade for Cardiovascular Disease Prevention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2020-12-01
Completion:: 2024-10-01

Conditions

Cardiovascular Disease
Hypertension
Care Coordination
HIV Treatment Cascade

Interventions

BEHAVIORAL

Results Available

NCT04527315 | RECRUITING

1500 participants

COVID-19 Survivorship Registry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2020-07-17
Completion:: 2027-12-31

Conditions

Covid19

Interventions

OTHER

No Results Yet

NCT04513080 | COMPLETED | NA

1184 participants

Message-Based Psychotherapy and Digital Treatment Sequences for Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2020-03-02
Completion:: 2024-01-14

Conditions

Study Adherence
Depressive Disorder

Interventions

BEHAVIORAL

Results Available

NCT04513028 | RECRUITING | NA

30 participants

Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2020-11-03
Completion:: 2026-07-31

Conditions

Melanoma Stage III
Melanoma Stage IV

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04511130 | TERMINATED | PHASE2

92 participants

Efficacy of MT-401 in Patients With AML Following Stem Cell Transplant

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2020-10-14
Completion:: 2024-03-01

Conditions

Acute Myeloid Leukemia
Stem Cell Transplantation

Interventions

DRUG

No Results Yet

NCT04508088 | RECRUITING

92 participants

Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2020-09-10
Completion:: 2026-12-31

Conditions

Inflammatory Bowel Disease
Crohn Disease

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04292405 | TERMINATED

60 participants

Accuracy of Cardiac Acoustic Biomarkers Recorded by the Wearable Cardioverter Defibrillator

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2020-01-23
Completion:: 2025-09-30

Conditions

Heart Failure

Interventions

DEVICE

No Results Yet

NCT04229017 | ACTIVE_NOT_RECRUITING | NA

236 participants

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2020-03-18
Completion:: 2024-07-22

Conditions

Degenerative Disc Disease

Interventions

PROCEDURE
DEVICE

No Results Yet

NCT04195685 | COMPLETED | NA

87 participants

Neurofeedback Impact on Veterans With mTBI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2021-03-16
Completion:: 2024-09-16

Conditions

Concussion
mTBI
Post-Concussive Symptoms
Chronic Headache
Chronic Insomnia
Chronic Attention Disorder

Interventions

PROCEDURE

Results Available

NCT04003311 | ENROLLING_BY_INVITATION

146 participants

MDR - Comprehensive Primary/Micro Stem & Versa-Dial Ti Humeral Head

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2019-12-13
Completion:: 2028-07-29

Conditions

Shoulder Pain
Shoulder Injuries
Shoulder Fractures
Shoulder Disease
Shoulder Arthritis

Interventions

DEVICE

No Results Yet

NCT03927768 | ACTIVE_NOT_RECRUITING

264 participants

Abbreviated Breast MRI (AB-MRI) With Golden-angle Radial Compressed-sensing and Parallel Imaging (GRASP)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-30
Start Date:: 2018-07-31
Completion:: 2023-08-31

Conditions

Breast Cancer

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT03904862 | TERMINATED | PHASE1/PHASE2

21 participants

Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-30
Start Date:: 2019-07-25
Completion:: 2025-08-11

Conditions

Medulloblastoma, Childhood
Medulloblastoma Recurrent
Medulloblastoma

Interventions

DRUG

No Results Yet