Clinical Trials Updated in 2025

NCT06336525 | ENROLLING_BY_INVITATION

3680 participants

Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-05-08
Completion:: 2027-01-31

Conditions

Sleep Apnea
Insomnia
Sleep Deprivation
Sleep Disorders, Circadian Rhythm
Sleepiness, Excessive Daytime
Fatigue

No Results Yet

NCT06335407 | RECRUITING | PHASE1

10 participants

Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2025-07-28
Completion:: 2026-03-30

Conditions

Alcohol Use Disorder (AUD)
Post Traumatic Stress Disorder (PTSD)

Interventions

DRUG

No Results Yet

NCT06335173 | ACTIVE_NOT_RECRUITING | PHASE2

542 participants

A Study to Evaluate Efficacy and Safety of Intravenous Sabirnetug in Participants With Early Alzheimer's Disease (ALTITUDE-AD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-02-29
Completion:: 2026-10-31

Conditions

Alzheimer Disease

Interventions

DRUG

No Results Yet

NCT06266429 | ACTIVE_NOT_RECRUITING

84 participants

Metabolomic Profiling of Racial Disparity

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-03-12
Completion:: 2024-11-22

Conditions

Adenoid Hypertrophy
Tonsillar Hypertrophy
Surgery

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06232915 | WITHDRAWN

0 participants

Accuracy of the Set Tidal Volume During Intraoperative Mechanical Ventilation

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-27
Start Date:: 2025-06-30
Completion:: 2026-12-31

Conditions

Surgery
Mechanical Ventilation Pressure High

Interventions

PROCEDURE

No Results Yet

NCT06229236 | COMPLETED | NA

148 participants

Assessing Effectiveness of a Diabetes Navigator in Increasing Progression of Advanced Diabetes Technologies

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-02-13
Completion:: 2025-08-26

Conditions

Diabetes Mellitus, Type 1

Interventions

BEHAVIORAL

No Results Yet

NCT06218823 | COMPLETED | PHASE4

52 participants

Tobacco Treatment Comparison for Cancer Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-03-01
Completion:: 2025-08-04

Conditions

Smoking Cessation
Cancer

Interventions

DRUG
BEHAVIORAL
OTHER

Results Available

NCT06171945 | COMPLETED | NA

63 participants

Mobile Weight Loss Intervention for Adolescent and Young Adult Cancer Survivors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-03-01
Completion:: 2025-07-13

Conditions

Cancer
Physical Activity
Cancer Survivorship
Mental Health
Obesity

Interventions

BEHAVIORAL

No Results Yet

NCT06158958 | TERMINATED | PHASE1

27 participants

A Study to Assess the Safety, Pharmacokinetics, and Efficacy of Intravenous (IV) ABBV-303, as Monotherapy and in Combination With IV Infused Budigalimab (ABBV-181), in Adults With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-02-06
Completion:: 2025-10-22

Conditions

Solid Tumors

Interventions

DRUG

No Results Yet

NCT06153446 | COMPLETED

810 participants

Infection Consortium Study#1

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-12-10
Completion:: 2025-09-04

Conditions

PJI

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06095063 | RECRUITING | NA

30 participants

dTMS for Subjective Cognitive Decline

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-11-15
Completion:: 2026-10-01

Conditions

Alzheimer Disease
Subjective Cognitive Decline

Interventions

DEVICE
OTHER

No Results Yet

NCT06077149 | COMPLETED | PHASE4

152 participants

Immunogenicity of RSV Vaccines in Residents of Long-Term Care Facilities (LTCF)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-11-07
Completion:: 2024-11-01

Conditions

Respiratory Syncytial Virus (RSV)

Interventions

BIOLOGICAL

Results Available

NCT05961215 | COMPLETED | NA

31 participants

Scalp Cooling to Prevent Hair Loss in Patients Undergoing Stem Cell Transplantation for Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-08-10
Completion:: 2024-11-01

Conditions

Multiple Myeloma

Interventions

DEVICE

Results Available

NCT05896202 | COMPLETED | NA

28 participants

Addressing Disparities in Neuromodulation for Rehabilitation: A Mixed Methods Approach to Optimize Access for Underrepresented Racial Minorities

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-01-15
Completion:: 2024-07-19

Conditions

Neuropathic Pain

Interventions

OTHER

Results Available

NCT05779943 | ACTIVE_NOT_RECRUITING | PHASE2

20 participants

Comparison of 18F-rhPSMA-7.3 PET/CT With and Without Furosemide in Biochemical Recurrence of Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-04-27
Completion:: 2024-03-15

Conditions

Prostate Adenocarcinoma
Recurrent Prostate Carcinoma

Interventions

DRUG
OTHER
PROCEDURE

Results Available

NCT05730556 | TERMINATED | NA

80 participants

A Study of Remote Electrical Neuromodulation for Acute Procedural Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-02-13
Completion:: 2024-09-09

Conditions

Chronic Migraine

Interventions

DEVICE

Results Available

NCT05726591 | RECRUITING | NA

44 participants

Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Disorders

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-05-02
Completion:: 2027-10-31

Conditions

Cerebral Palsy
Muscular Dystrophy
Spina Bifida
Incomplete Spinal Cord Injury

Interventions

DEVICE

No Results Yet

NCT05529472 | COMPLETED | NA

81 participants

Safety and Effectiveness Evaluation of Peripheral Orbital Atherectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-01-10
Completion:: 2024-04-01

Conditions

Peripheral Artery Disease

Interventions

DEVICE

Results Available

NCT05424042 | COMPLETED | NA

90 participants

Health, Aging and Later-Life Outcomes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-07-05
Completion:: 2024-07-22

Conditions

Aging

Interventions

BEHAVIORAL

Results Available

NCT05418894 | RECRUITING | NA

84 participants

Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-04-01
Completion:: 2027-03-31

Conditions

Treatment Resistant Depression
Epilepsy

Interventions

DEVICE

No Results Yet

NCT05407714 | COMPLETED | NA

15 participants

SpaceOAR System RWS in China

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-08-18
Completion:: 2023-06-12

Conditions

Localized T1-T2 Prostate Cancer

Interventions

DEVICE

Results Available

NCT05406115 | COMPLETED | PHASE1

65 participants

Single and Multiple Ascending Dose Study to Evaluate AMG 786 in Healthy Participants and Participants With Obesity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-07-26
Completion:: 2023-08-21

Conditions

Obesity

Interventions

DRUG
OTHER

No Results Yet

NCT05378529 | COMPLETED | NA

39480 participants

A Cross-sectional Study of Lipoprotein(a) Levels in Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-04-19
Completion:: 2023-12-30

Conditions

Atherosclerotic Cardiovascular Disease

Interventions

OTHER

No Results Yet

NCT05366140 | RECRUITING

300 participants

Thoracic-Lumbar Arthrodesis- Implanet Jazz

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-02-03
Completion:: 2026-09-30

Conditions

Spondylolisthesis
Spinal Stenosis
Degenerative Disease

Interventions

OTHER

No Results Yet

NCT05351333 | ACTIVE_NOT_RECRUITING | NA

66 participants

Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-08-03
Completion:: 2025-07-31

Conditions

Spinal Cord Injuries
Polytrauma
Burns

Interventions

OTHER

No Results Yet

NCT05346575 | ACTIVE_NOT_RECRUITING | NA

440 participants

TOTAL: A Multisite RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2023-01-23
Completion:: 2026-08-31

Conditions

Obesity
Overweight

Interventions

BEHAVIORAL

No Results Yet

NCT05330468 | COMPLETED

200 participants

Regent China Post-Market Clinical Follow-up Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-03-29
Completion:: 2024-10-10

Conditions

Valvular Heart Disease
Aortic Valve Disease

Interventions

DEVICE

Results Available

NCT05323123 | COMPLETED | NA

120 participants

Pre-exposure Prophylaxis Implementation in Central-Eastern European Countries

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2021-10-01
Completion:: 2024-09-30

Conditions

Human Immunodeficiency Virus

Interventions

BEHAVIORAL

Results Available

NCT05308368 | COMPLETED | NA

12 participants

Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2021-04-11
Completion:: 2025-07-31

Conditions

Parkinson Disease
Essential Tremor

Interventions

DEVICE

Results Available

NCT05299515 | COMPLETED | NA

200 participants

Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-04-05
Completion:: 2025-09-24

Conditions

Substance-Related Disorders
Opioid Medication Assisted Treatment
Opioid Use Disorder
Opioid Use
Opioid Addiction
Treatment Adherence
Retention in Care

Interventions

BEHAVIORAL

No Results Yet

NCT05239793 | ACTIVE_NOT_RECRUITING | EARLY_PHASE1

30 participants

Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-11-22
Completion:: 2025-06-30

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

DRUG

No Results Yet

NCT05187013 | COMPLETED | NA

123 participants

Uncontrolled Hypertension Among the Homeless

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-09-12
Completion:: 2025-09-15

Conditions

Hypertension

Interventions

BEHAVIORAL

Results Available

NCT04996472 | COMPLETED | NA

933 participants

A Framework For Linking Sequential Pattern Rules in DLD: Perception in Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2020-08-03
Completion:: 2025-05-17

Conditions

Developmental Language Disorder
Speech Sound Disorder
Specific Language Impairment

Interventions

BEHAVIORAL

No Results Yet

NCT04824443 | COMPLETED | PHASE1

3 participants

Exercise Therapy in Cancer Patients Who Are Recovering From COVID-19

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2021-03-29
Completion:: 2025-10-24

Conditions

Covid19
Coronavirus
Cancer

Interventions

OTHER

No Results Yet

NCT04791969 | COMPLETED | PHASE2

60 participants

Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2021-12-14
Completion:: 2024-03-01

Conditions

Methamphetamine Use Disorder

Interventions

DRUG
BEHAVIORAL

Results Available

NCT04658095 | TERMINATED | NA

10 participants

Study of OMNI Surgical System and iStent for Eyes With OAG (Trident)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2022-01-11
Completion:: 2022-11-18

Conditions

Glaucoma, Open-Angle

Interventions

DEVICE

Results Available

NCT04636073 | WITHDRAWN | NA

0 participants

The Leaflex™ Early Feasibility Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2024-06-01
Completion:: 2024-06-01

Conditions

Aortic Valve Stenosis

Interventions

DEVICE

No Results Yet

NCT04578756 | COMPLETED | PHASE3

310 participants

Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2021-02-01
Completion:: 2025-10-06

Conditions

Schizophrenia
Bipolar I Disorder
Autism Spectrum Disorder (ASD)

Interventions

DRUG

No Results Yet

NCT04574635 | ACTIVE_NOT_RECRUITING

18 participants

Human Papilloma Virus (HPV) Circulating Tumor DNA (ctDNA) in Cervical Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-27
Start Date:: 2020-11-17
Completion:: 2025-09-10

Conditions

Cervical Adenosquamous Carcinoma
Cervical Squamous Cell Carcinoma, Not Otherwise Specified
Infiltrating Cervical Carcinoma
Metastatic Cervical Carcinoma
Recurrent Cervical Carcinoma
Stage I Cervical Cancer FIGO 2018
Stage IA Cervical Cancer FIGO 2018
Stage IA1 Cervical Cancer FIGO 2018
Stage IA2 Cervical Cancer FIGO 2018
Stage IB Cervical Cancer FIGO 2018
Stage IB1 Cervical Cancer AJCC v8
Stage IB2 Cervical Cancer FIGO 2018
Stage IB3 Cervical Cancer FIGO 2018
Stage II Cervical Cancer FIGO 2018
Stage IIA Cervical Cancer FIGO 2018
Stage IIA1 Cervical Cancer FIGO 2018
Stage IIA2 Cervical Cancer FIGO 2018
Stage IIB Cervical Cancer FIGO 2018
Stage III Cervical Cancer FIGO 2018
Stage IIIA Cervical Cancer FIGO 2018
Stage IIIB Cervical Cancer FIGO 2018
Stage IIIC Cervical Cancer FIGO 2018
Stage IIIC1 Cervical Cancer FIGO 2018
Stage IIIC2 Cervical Cancer FIGO 2018
Stage IV Cervical Cancer FIGO 2018
Stage IVA Cervical Cancer FIGO 2018
Stage IVB Cervical Cancer FIGO 2018

Interventions

PROCEDURE

No Results Yet

NCT04567784 | COMPLETED | PHASE2

66 participants

Neuroimaging and CBD for Opioid Use Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-27
Start Date:: 2020-11-12
Completion:: 2025-06-18

Conditions

Heroin Abuse
Opioid Use Disorder
Substance-Related Disorders
Opioid-Related Disorders

Interventions

DRUG

No Results Yet