Clinical Trials Updated in 2025

NCT04767282 | COMPLETED | NA

1400 participants

Assessment of a Fruit and Vegetable Prescription Program for Children

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-02-23
Completion:: 2024-05-30

Conditions

Exposure to Fruit and Vegetable Prescription Program

Interventions

OTHER

Results Available

NCT04706013 | RECRUITING | PHASE3

15 participants

Oral Pyridoxal 5'-Phosphate for the Treatment of Patients With PNPO Deficiency

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2024-02-16
Completion:: 2026-11-30

Conditions

Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency

Interventions

DRUG

No Results Yet

NCT04688476 | ACTIVE_NOT_RECRUITING

113 participants

An Extended Follow-Up Study of the HPV Vaccine Delayed Booster Trial

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-11-17
Completion:: 2025-09-09

Conditions

HPV-associated Cancer

No Results Yet

NCT04666259 | COMPLETED | PHASE3

56 participants

Asciminib in Monotherapy for Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and Without T315I Mutation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-05-25
Completion:: 2023-06-20

Conditions

Chronic Myelogenous Leukemia - Chronic Phase

Interventions

DRUG

Results Available

NCT04659993 | TERMINATED | NA

10 participants

Cancer Within a Pandemic: A Telemental Health Intervention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-03-10
Completion:: 2021-06-09

Conditions

Cancer
Survivorship
Depression, Anxiety

Interventions

BEHAVIORAL

Results Available

NCT04636229 | COMPLETED | PHASE3

516 participants

Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-12-14
Completion:: 2023-07-30

Conditions

Knee Osteoarthritis

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT04632927 | COMPLETED | PHASE3

119 participants

Efficacy of Secukinumab Compared to Ustekinumab in Adults With Active Psoriatic Arthritis and Failure of TNFα-Inhibitor Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-12-21
Completion:: 2024-10-22

Conditions

Psoriatic Arthritis

Interventions

BIOLOGICAL

Results Available

NCT04623216 | TERMINATED | PHASE1/PHASE2

24 participants

Sabatolimab as a Treatment for Patients With Acute Myeloid Leukemia and Presence of Measurable Residual Disease After Allogeneic Stem Cell Transplantation.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-09-14
Completion:: 2024-08-22

Conditions

Acute Myeloid Leukemia

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04610346 | COMPLETED | NA

17 participants

Assessing an Animal-Assisted Treatment Program for Adults With Aphasia: The Persons With Aphasia Training Dogs Program

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2023-03-30
Completion:: 2024-08-28

Conditions

Aphasia

Interventions

BEHAVIORAL

Results Available

NCT04601831 | COMPLETED | PHASE1/PHASE2

14 participants

'Re-Priming' RT After Incomplete Response to CAR-T in R/R NHL

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-12-23
Completion:: 2024-08-06

Conditions

Non-Hodgkin Lymphoma

Interventions

RADIATION

No Results Yet

NCT04541589 | COMPLETED | PHASE2

206 participants

Study of Safety and Tolerability of CFZ533 in Patients With Sjögren's Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-01-05
Completion:: 2024-08-19

Conditions

Sjogren's Syndrome

Interventions

DRUG
OTHER

Results Available

NCT04541017 | TERMINATED | PHASE1/PHASE2

8 participants

Testing the Addition of an Anti-cancer Drug, Hu5F9-G4 (Magrolimab), to the Usual Chemotherapy Treatment (Mogamulizumab) in T-Cell (a Type of Immune Cell) Lymphoma That Has Returned After Treatment or Does Not Respond to Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-04-06
Completion:: 2024-10-24

Conditions

Mycosis Fungoides
Recurrent Mycosis Fungoides
Recurrent Mycosis Fungoides and Sezary Syndrome
Recurrent Sezary Syndrome
Refractory Mycosis Fungoides
Refractory Mycosis Fungoides and Sezary Syndrome
Refractory Sezary Syndrome
Sezary Syndrome
Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8
Stage II Mycosis Fungoides and Sezary Syndrome AJCC v8
Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8
Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8

Interventions

PROCEDURE
BIOLOGICAL

Results Available

NCT04533555 | COMPLETED | NA

749 participants

Genetic Testing in Young Adults With Cancer Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-12-01
Completion:: 2025-09-26

Conditions

Cancer

Interventions

GENETIC

No Results Yet

NCT04526639 | COMPLETED | NA

14 participants

VR Cognitive Rehabiliation for Pediatric TBI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-09-03
Completion:: 2024-08-31

Conditions

TBI (Traumatic Brain Injury)

Interventions

BEHAVIORAL

Results Available

NCT04495751 | COMPLETED | EARLY_PHASE1

64 participants

Muscadine Grape Extract to Improve Fatigue

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-04-20
Completion:: 2024-08-26

Conditions

Fatigue

Interventions

DIETARY_SUPPLEMENT
DRUG
OTHER

Results Available

NCT04390763 | TERMINATED | PHASE2

164 participants

Study of Efficacy and Safety of NIS793 (With and Without Spartalizumab) in Combination With SOC Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-10-16
Completion:: 2024-04-26

Conditions

Metastatic Pancreatic Ductal Adenocarcinoma

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04376346 | COMPLETED | NA

439 participants

Preventing Alcohol Exposed Pregnancy Among Urban Native Young Women: Mobile CHOICES

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-08-04
Completion:: 2024-02-25

Conditions

Alcohol Exposed Pregnancy

Interventions

BEHAVIORAL

Results Available

NCT04337554 | COMPLETED

47 participants

Exoskeleton Footwear to Improve Walking

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-08-01
Completion:: 2025-09-30

Conditions

Peripheral Arterial Disease

Interventions

DEVICE

No Results Yet

NCT04278417 | COMPLETED | PHASE3

689 participants

Study of Efficacy and Safety of Brolucizumab Versus Panretinal Photocoagulation Laser in Patients With Proliferative Diabetic Retinopathy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-11-19
Completion:: 2023-10-30

Conditions

Proliferative Diabetic Retinopathy

Interventions

BIOLOGICAL
PROCEDURE

Results Available

NCT04272034 | TERMINATED | PHASE1

105 participants

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2021-03-26
Completion:: 2024-08-16

Conditions

Advanced Solid Tumors
MSI-H/dMMR Tumors
Cutaneous Squamous Cell Carcinoma
Urothelial Carcinoma, HCC
Cervical Cancer
Esophageal Squamous Cell Carcinoma
Merkel Cell Carcinoma
Small-cell Lung Cancer
Mesothelioma
PD-L1 Amplified Tumor (9p24.1)
Nasopharyngeal Carcinoma
Cyclin-dependent Kinase 12 Mutated Tumors
Basal Cell Carcinoma (Unresectable or Metastatic)
Sarcomatoid Renal Cell Carcinoma
Clear Cell Ovarian or Endometrial Carcinoma
Anal Carcinoma
Squamous Cell Penile Carcinoma
DNA Polymerase Epsilon Mutated Tumors (P286R and V411L)

Interventions

DRUG

No Results Yet

NCT04178122 | COMPLETED | NA

112 participants

Million Veteran Program Return of Actionable Results

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2020-02-27
Completion:: 2024-09-08

Conditions

Cardiovascular Disease

Interventions

GENETIC

Results Available

NCT04141761 | ACTIVE_NOT_RECRUITING | PHASE2

43 participants

Probiotics in Newly Diagnosed T1D

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-04-01
Completion:: 2023-03-30

Conditions

Type 1 Diabetes
Type1diabetes
Type 1 Diabetes Mellitus

Interventions

DIETARY_SUPPLEMENT
OTHER

No Results Yet

NCT04123496 | COMPLETED | NA

38 participants

rTMS to Enhance Cognitive Performance and Promote Resilience

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-11-21
Completion:: 2021-09-27

Conditions

Cognition
Stress Reaction

Interventions

DEVICE

Results Available

NCT04066244 | TERMINATED | PHASE2

28 participants

Study of Safety and Proof of the Mechanism of BLZ945 in ALS Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-12-30
Completion:: 2024-02-01

Conditions

Amyotrophic Lateral Sclerosis

Interventions

DRUG

Results Available

NCT04053868 | COMPLETED | NA

17 participants

Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-12-09
Completion:: 2022-03-31

Conditions

Nicotine Administration & Dosage
E-cigarettes
Vaping
E-Liquid
Tobacco Smoking

Interventions

OTHER

Results Available

NCT04050462 | TERMINATED | PHASE2

13 participants

Nivolumab Combined With BMS-986253 in HCC Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-09-12
Completion:: 2025-01-31

Conditions

Hepatocellular Carcinoma

Interventions

DRUG

Results Available

NCT04042467 | COMPLETED | NA

900 participants

Greenlight Plus Study: Approaches to Early Childhood Obesity Prevention

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-11-06
Completion:: 2024-01-17

Conditions

Behavior, Health
Child Obesity

Interventions

BEHAVIORAL

Results Available

NCT04015518 | COMPLETED | PHASE2

152 participants

A Study to Test How Effective and Safe Different Doses of BI 655130 Are in Patients With a Moderate to Severe Form of the Skin Disease Palmoplantar Pustulosis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-07-31
Completion:: 2020-08-06

Conditions

Palmoplantar Pustulosis (PPP)

Interventions

DRUG

Results Available

NCT04010240 | COMPLETED

3820 participants

A Retrospective Study to Determine the Incidence of NTRK Fusions. NTRK Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-16
Start Date:: 2015-12-23
Completion:: 2022-12-31

Conditions

Metastatic Solid Tumors

Interventions

OTHER

Results Available

NCT03879161 | WITHDRAWN | NA

0 participants

A Percutaneous Ultrasound Device With Needle Guide for Vascular Access

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2026-09-30
Completion:: 2028-12-31

Conditions

Vascular Access

Interventions

DEVICE

No Results Yet

NCT03867201 | COMPLETED | PHASE3

557 participants

Study of Efficacy and Safety of Erenumab in Adult Chronic Migraine Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-08-26
Completion:: 2021-08-11

Conditions

Migraine

Interventions

BIOLOGICAL
OTHER

Results Available

NCT03827291 | COMPLETED | PHASE4

35 participants

QL Block With Exparel in Colectomy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-10-31
Completion:: 2022-12-02

Conditions

Laparotomy
Colectomy

Interventions

DRUG
OTHER

Results Available

NCT03822468 | COMPLETED | PHASE2

376 participants

Study of 2 Ribociclib Doses in Combination With Aromatase Inhibitors in Women With HR+, HER2- Advanced Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-06-11
Completion:: 2021-06-11

Conditions

Breast Cancer

Interventions

DRUG

Results Available

NCT03792841 | TERMINATED | PHASE1

212 participants

Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-02-05
Completion:: 2023-06-29

Conditions

Metastatic Castration-resistant Prostate Cancer
Prostate Cancer

Interventions

DRUG

No Results Yet

NCT03782792 | COMPLETED | PHASE2

53 participants

Effisayil™ 1: A Study to Test Spesolimab (BI 655130) in Patients With a Flare-up of a Skin Disease Called Generalized Pustular Psoriasis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-01-31
Completion:: 2020-09-23

Conditions

Generalized Pustular Psoriasis

Interventions

DRUG

Results Available

NCT03769168 | COMPLETED | PHASE3

55 participants

An Extension Study of Subcutaneous Secukinumab in Patients With Juvenile Psoriatic Arthritis (JPsA) and Enthesitis Related Arthritis (ERA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-06-07
Completion:: 2024-11-07

Conditions

Juvenile Psoriatic Arthritis
Enthesitis Related Arthritis

Interventions

DRUG

Results Available

NCT03760744 | COMPLETED | NA

18 participants

Imaging Biomarkers of Lymphatic Dysfunction

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-01-23
Completion:: 2025-03-15

Conditions

Secondary Lymphedema

Interventions

PROCEDURE

Results Available

NCT03752970 | COMPLETED | PHASE2

27 participants

A Study Testing How BI 655130 Works in Patients With Fistulizing Crohn's Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-02-05
Completion:: 2021-12-01

Conditions

Crohn Disease

Interventions

DRUG

Results Available

NCT03584854 | COMPLETED | PHASE4

100 participants

Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2019-03-01
Completion:: 2022-05-22

Conditions

Postpartum Hemorrhage
Uterine Atony

Interventions

DRUG

Results Available

NCT03581123 | COMPLETED | PHASE3

1000 participants

Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-16
Start Date:: 2018-11-01
Completion:: 2024-06-12

Conditions

Acute Pain
Low Back Pain, Mechanical

Interventions

BEHAVIORAL
OTHER
COMBINATION_PRODUCT
DRUG

Results Available