Clinical Trials Updated in 2025

NCT04742777 | COMPLETED | PHASE2

20 participants

Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2022-02-01
Completion:: 2025-09-09

Conditions

Aging

Interventions

DRUG

No Results Yet

NCT04692779 | COMPLETED

60 participants

A Prospective Clinical Study to Explore Response to Prone Positioning in ARDS Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-01-31
Completion:: 2022-01-31

Conditions

Covid19
ARDS

Interventions

OTHER

No Results Yet

NCT04654689 | COMPLETED | PHASE2

90 participants

Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-11-20
Completion:: 2022-11-12

Conditions

Amyotrophic Lateral Sclerosis

Interventions

DIETARY_SUPPLEMENT
OTHER
DRUG

No Results Yet

NCT04572243 | TERMINATED | PHASE3

22 participants

A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-09-23
Completion:: 2024-08-15

Conditions

Epilepsies, Myoclonic

Interventions

DRUG

Results Available

NCT04539717 | ENROLLING_BY_INVITATION

820 participants

FAST (Focused Abbreviated Screening Technique)-MRI Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-08-17
Completion:: 2026-05-31

Conditions

Hepatocellular Carcinoma (HCC)
Liver Cirrhosis

No Results Yet

NCT04479475 | COMPLETED | NA

58 participants

Social Networks and Methadone Maintenance Treatment Retention and Antiretroviral Therapy Retention in Tanzania

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2024-03-01
Completion:: 2024-09-05

Conditions

Opioid-use Disorder
Adherence, Medication
HIV Infections

Interventions

BEHAVIORAL

Results Available

NCT04459715 | TERMINATED | PHASE3

730 participants

A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-08-07
Completion:: 2024-09-18

Conditions

Squamous Cell Carcinoma of the Head and Neck

Interventions

DRUG
RADIATION

Results Available

NCT04438213 | RECRUITING | PHASE2

60 participants

Ertugliflozin in Chronic Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-03-10
Completion:: 2025-12-30

Conditions

Heart Failure

Interventions

DRUG

No Results Yet

NCT04370587 | RECRUITING | PHASE1/PHASE2

30 participants

A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-09-17
Completion:: 2026-09-22

Conditions

Solid Tumor
Melanoma
HNSCC
Sarcoma
Squamous Cell Carcinoma
NSCLC

Interventions

BIOLOGICAL
COMBINATION_PRODUCT

No Results Yet

NCT04323098 | COMPLETED | PHASE3

22 participants

Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-12-08
Completion:: 2023-01-27

Conditions

Hemophilia A

Interventions

BIOLOGICAL

Results Available

NCT04189445 | TERMINATED | PHASE2

115 participants

Futibatinib in Patients With Specific FGFR Aberrations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-08-05
Completion:: 2024-11-11

Conditions

Advanced or Metastatic Solid Tumor
Advanced or Metastatic Gastric or Gastroesophageal Cancer
Myeloid or Lymphoid Neoplasms (MLN)

Interventions

DRUG

Results Available

NCT04143243 | COMPLETED | NA

176 participants

One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2020-07-01
Completion:: 2024-08-03

Conditions

Traumatic Brain Injury
Chronic Pain
Post Traumatic Stress Disorder
Depression
Anxiety

Interventions

BEHAVIORAL

Results Available

NCT04136951 | COMPLETED | NA

1915 participants

Improving Patient Prioritization During Hospital-homecare Transition

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2023-08-01
Completion:: 2024-04-01

Conditions

Diabetes Mellitus, Type 2
Congestive Heart Failure
Obstructive Pulmonary Disease
Dyspnea
Renal Failure

Interventions

OTHER

Results Available

NCT03959527 | COMPLETED | PHASE3

1011 participants

Zoliflodacin in Uncomplicated Gonorrhoea

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2019-11-06
Completion:: 2023-08-30

Conditions

Gonorrhea

Interventions

DRUG

Results Available

NCT03873467 | ACTIVE_NOT_RECRUITING | NA

65 participants

Group Lifestyle Balance™ for Individuals With Stroke (GLB-CVA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2019-07-08
Completion:: 2022-12-30

Conditions

Stroke

Interventions

BEHAVIORAL
OTHER

No Results Yet

NCT03821272 | COMPLETED | PHASE1/PHASE2

17 participants

A Phase I/II Clinical Trial of PepCan in Head and Neck Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2019-11-13
Completion:: 2025-02-03

Conditions

Head and Neck Cancer

Interventions

BIOLOGICAL

Results Available

NCT03817502 | RECRUITING | PHASE3

330 participants

Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2019-06-06
Completion:: 2026-12-15

Conditions

Schizophrenia

Interventions

DRUG

No Results Yet

NCT03692312 | COMPLETED | PHASE2/PHASE3

56 participants

Efficacy and Safety of Tideglusib in Congenital Myotonic Dystrophy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2021-03-03
Completion:: 2023-04-04

Conditions

Congenital Myotonic Dystrophy

Interventions

DRUG

Results Available

NCT03551951 | RECRUITING

320 participants

Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-08
Start Date:: 2016-07-01
Completion:: 2027-12-30

Conditions

Non Small Cell Lung Cancer
Esophageal Cancer
Gastric Cancer
Pancreatic Cancer
Hepatocellular Cancer
Colorectal Cancer

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT03471364 | COMPLETED | EARLY_PHASE1

58 participants

Ketoconazole in Treating Participants With Ongoing EGFR Inhibitor-Induced Rash

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2018-09-25
Completion:: 2024-09-15

Conditions

Malignant Neoplasm

Interventions

DRUG
OTHER

No Results Yet

NCT03418961 | RECRUITING | PHASE3

491 participants

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2017-11-01
Completion:: 2027-09-15

Conditions

Cardiotoxicity
HER2/Neu Positive
Metastatic Malignant Neoplasm in the Brain
Recurrent Breast Carcinoma
Stage IV Breast Cancer AJCC v6 and v7

Interventions

DRUG
OTHER

No Results Yet

NCT03373227 | COMPLETED | PHASE2

50 participants

Phase II Study Evaluating the Efficacy of Tacrolimus Extended Release Tablets to Twice Daily Tacrolimus Dosing Regimen

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2017-12-04
Completion:: 2023-12-30

Conditions

Heart Transplant Rejection
Graft Failure
Compliance, Patient

Interventions

DRUG

No Results Yet

NCT03287908 | TERMINATED | PHASE1

174 participants

A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2017-11-13
Completion:: 2023-06-30

Conditions

Relapsed/Refractory Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT03253744 | COMPLETED | PHASE1

17 participants

Prostate SBRT for Locally Recurrent Prostate Cancer After Prior Radiotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2018-07-05
Completion:: 2023-05-03

Conditions

Prostate Cancer
Prostatic Neoplasm

Interventions

DRUG
RADIATION

Results Available

NCT02960893 | COMPLETED | PHASE2/PHASE3

141 participants

Trial in Adult Participants With Spinocerebellar Ataxia (SCA)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2016-12-15
Completion:: 2017-08-18

Conditions

Spinocerebellar Ataxias
Spinocerebellar Ataxia Genotype Type 1
Spinocerebellar Ataxia Genotype Type 2
Spinocerebellar Ataxia Genotype Type 3
Spinocerebellar Ataxia Genotype Type 6
Spinocerebellar Ataxia Genotype Type 7
Spinocerebellar Ataxia Genotype Type 8
Spinocerebellar Ataxia Genotype Type 10

Interventions

DRUG

Results Available

NCT02786277 | COMPLETED | NA

2046 participants

Learning Alerts for Acute Kidney Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2024-02-15
Completion:: 2024-08-14

Conditions

Acute Kidney Injury

Interventions

OTHER

Results Available

NCT02684201 | COMPLETED | NA

4 participants

Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2015-11-01
Completion:: 2024-08-01

Conditions

Phantom Limb

Interventions

DEVICE

Results Available

NCT01979367 | ACTIVE_NOT_RECRUITING | NA

1000 participants

Physician Clinical Trial Policy (CTP) Neurological Ischemia Lower Extremity Pain and Swelling

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2012-03-31
Completion:: 2027-01-31

Conditions

Lower Extremity Swelling Acute

Interventions

DEVICE

No Results Yet

NCT01688466 | COMPLETED | PHASE2

34 participants

Pomalidomide for Chronic Graft-versus-Host Disease

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2012-08-30
Completion:: 2017-03-30

Conditions

Graft vs Host Disease
Graft-Versus-Host Disease

Interventions

DRUG

Results Available

NCT01000350 | ACTIVE_NOT_RECRUITING | NA

40 participants

Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2009-10-31
Completion:: 2028-06-30

Conditions

Postural Tachycardia Syndrome

Interventions

DRUG
OTHER

No Results Yet

NCT00692471 | ACTIVE_NOT_RECRUITING

100 participants

Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-08
Start Date:: 2008-06-30
Completion:: 2029-12-31

Conditions

Postural Tachycardia Syndrome
Orthostatic Intolerance
Sleep Disorders

Interventions

DEVICE

No Results Yet

NCT00608725 | ACTIVE_NOT_RECRUITING | NA

260 participants

Pathophysiology of Orthostatic Intolerance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 1996-12-31
Completion:: 2029-12-31

Conditions

Tachycardia
Postural Orthostatic Tachycardia Syndrome

Interventions

RADIATION
PROCEDURE
DRUG

No Results Yet

NCT00581321 | ACTIVE_NOT_RECRUITING | NA

40 participants

Oral Water Ingestion in Heart Transplant Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 2006-01-31
Completion:: 2029-12-31

Conditions

Blood Pressure
Cardiac Transplantation

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT00262470 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

150 participants

Treatment of Orthostatic Intolerance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-08
Start Date:: 1997-04-30
Completion:: 2029-12-31

Conditions

Tachycardia
Chronic Orthostatic Intolerance

Interventions

DRUG
OTHER
DIETARY_SUPPLEMENT
RADIATION
PROCEDURE
DEVICE

No Results Yet

NCT07211360 | NOT_YET_RECRUITING

270 participants

Integrated PET/MR Imaging With Amino Acid Radiotracers in the Evaluation of Brain Neoplasms: Assessing Diagnostic Accuracy and Therapeutic Response

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-07
Start Date:: 2025-10-01
Completion:: 2028-09-30

Conditions

Primary and Secondary Brain Tumors

No Results Yet

NCT07211347 | RECRUITING | PHASE4

64 participants

Percutaneous Blockade of the Stellate Ganglion in Electrical Storm

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2025-06-06
Completion:: 2028-06-30

Conditions

Electrical Storm
Stellate Ganglion Block
Ventricular Arrhythmia

Interventions

PROCEDURE

No Results Yet

NCT07211321 | RECRUITING

1220 participants

Linking Diet, Inflammation, Gut Microbiota, and Sarcopenia: A Cross-Sectional Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-07
Start Date:: 2024-04-16
Completion:: 2025-12-31

Conditions

Sarcopenia

Interventions

OTHER

No Results Yet

NCT07211295 | COMPLETED

25 participants

Accurate AI-based Characterisation of Surface Size, Depth and Tissue Composition in Hard-to-Heal Wounds

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-07
Start Date:: 2025-07-01
Completion:: 2025-09-18

Conditions

Difficult to Heal Wounds

No Results Yet

NCT07211269 | RECRUITING | NA

40 participants

Individual Differences in Cognitive Control Predict Real-time fMRI Neurofeedback Performance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2025-09-03
Completion:: 2025-12-27

Conditions

Healthy

Interventions

OTHER

No Results Yet

NCT07211256 | RECRUITING | NA

70 participants

Efficacy of Home-delivered Transcranial Direct Electrical Stimulation or Chronic Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2025-01-09
Completion:: 2028-02-29

Conditions

Neuropathic Pain
Nociplastic Pain

Interventions

DEVICE

No Results Yet