Clinical Trials Updated in 2025

NCT04723836 | ACTIVE_NOT_RECRUITING | NA

2250 participants

Optimal Nutrition for Prevention of Hypertension in Pregnancy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2017-03-01
Completion:: 2022-07-27

Conditions

Blood Pressure
Pregnancy

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04679012 | RECRUITING | PHASE2

20 participants

Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2021-09-24
Completion:: 2026-09-30

Conditions

Richter Syndrome
Chronic Lymphocytic Leukemia

Interventions

DRUG

No Results Yet

NCT04666649 | COMPLETED | PHASE1

27 participants

Pegcrisantaspase in Combination With Venetoclax for Treatment of Relapsed or Refractory Acute Myeloid Leukemia (R/R AML)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2021-03-10
Completion:: 2024-09-01

Conditions

Relapsed or Refractory Acute Myeloid Leukemia

Interventions

DRUG

No Results Yet

NCT04662918 | RECRUITING

3000 participants

Validation of CAGIB Score for In-hospital Mortality of Cirrhotic Patients With Acute Gastrointestinal Bleeding

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-07
Start Date:: 2022-01-01
Completion:: 2025-12-31

Conditions

GastroIntestinal Bleeding

No Results Yet

NCT04544111 | ACTIVE_NOT_RECRUITING | PHASE2

19 participants

PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-09-02
Completion:: 2026-09-02

Conditions

Thyroid Cancer
Thyroid Cancer, Follicular
Papillary Thyroid Cancer
Follicular Thyroid Cancer
Hurthle Cell Tumor
Poorly Differentiated Thyroid Gland Carcinoma
Hurthle Cell Thyroid Neoplasia

Interventions

DRUG

No Results Yet

NCT04487470 | COMPLETED | NA

89 participants

Impact of Cigar Flavor in Dual Users

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-06-24
Completion:: 2024-11-30

Conditions

Tobacco Use Disorder

Interventions

OTHER

No Results Yet

NCT04405167 | TERMINATED | PHASE1

30 participants

Tasquinimod for the Treatment of Relapsed or Refractory Myeloma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-07-10
Completion:: 2025-05-19

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT04365374 | ACTIVE_NOT_RECRUITING | PHASE3

230 participants

Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2021-04-06
Completion:: 2029-08-30

Conditions

Brain Metastases

Interventions

DEVICE
RADIATION

No Results Yet

NCT04362748 | COMPLETED | PHASE1

34 participants

Study of AMG 256 in Adult Subjects With Advanced Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-09-15
Completion:: 2023-09-21

Conditions

Advanced Solid Tumors

Interventions

DRUG

No Results Yet

NCT04269265 | COMPLETED | PHASE1/PHASE2

43 participants

The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Yellow Fever Vaccination

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-07-01
Completion:: 2023-10-23

Conditions

Yellow Fever

Interventions

BIOLOGICAL

Results Available

NCT04209660 | ACTIVE_NOT_RECRUITING | PHASE2

64 participants

Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-06-02
Completion:: 2026-12-31

Conditions

Adenoid Cystic Carcinoma
Salivary Gland Cancer

Interventions

DRUG

No Results Yet

NCT04191811 | RECRUITING

150 participants

Investigating Neural Response Variability as a Single-patient Predictor of Successful CBT in Clinical Psychiatry

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-07
Start Date:: 2022-04-01
Completion:: 2026-01-31

Conditions

Psychiatric Disorder
Depression
Anxiety Disorders
Insomnia

Interventions

BEHAVIORAL

No Results Yet

NCT04111627 | COMPLETED | PHASE2

43 participants

Exercise Plus Duloxetine for Knee Osteoarthritis

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2021-10-07
Completion:: 2025-08-11

Conditions

Knee Osteoarthritis
Depression

Interventions

BEHAVIORAL
DRUG

No Results Yet

NCT04095065 | COMPLETED | NA

3098 participants

Engineering an Online STI Prevention Program: RCT

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2019-07-15
Completion:: 2019-12-31

Conditions

Alcohol Consumption
Sexually Transmitted Diseases

Interventions

BEHAVIORAL

No Results Yet

NCT04073225 | COMPLETED | NA

23 participants

Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-01-25
Completion:: 2024-09-03

Conditions

Traumatic Brain Injury
Dementia Alzheimers
Military Activity

Interventions

DEVICE
BEHAVIORAL

Results Available

NCT04057209 | RECRUITING | NA

34 participants

VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2019-11-20
Completion:: 2027-11-30

Conditions

Glottis Tumor
Larynx Cancer

Interventions

RADIATION
PROCEDURE

No Results Yet

NCT03943511 | TERMINATED | NA

25 participants

Discharged With Indwelling Chest Tube and Valve

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2019-10-07
Completion:: 2023-11-20

Conditions

Prolonged Air Leak

Interventions

OTHER

No Results Yet

NCT03930251 | SUSPENDED | NA

117 participants

Cognitive Remediation for Coordinated Specialty Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2019-06-01
Completion:: 2023-10-31

Conditions

Schizophrenia
Schizoaffective Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT03901469 | TERMINATED | PHASE2

115 participants

A Study of ZEN003694 and Talazoparib in Patients With Triple Negative Breast Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2019-06-26
Completion:: 2024-03-07

Conditions

Triple Negative Breast Cancer

Interventions

DRUG

Results Available

NCT03892967 | COMPLETED | NA

50207 participants

Enhanced, EHR-facilitated Cancer Symptom Control Pragmatic Clinical Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2019-03-28
Completion:: 2023-01-31

Conditions

Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm

Interventions

OTHER

Results Available

NCT03776812 | COMPLETED | PHASE2

178 participants

Study of Relacorilant in Combination With Nab-Paclitaxel for Patients With Recurrent Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2019-04-05
Completion:: 2021-03-16

Conditions

Recurrent Ovarian Cancer
Recurrent Fallopian Tube Carcinoma
Recurrent Primary Peritoneal Carcinoma

Interventions

DRUG

Results Available

NCT03737370 | COMPLETED | PHASE1

43 participants

Fractionated Docetaxel and Radium 223 in Metastatic Castration-Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2018-01-30
Completion:: 2024-12-31

Conditions

Metastatic Castrate Resistant Prostate Cancer

Interventions

DRUG
RADIATION

No Results Yet

NCT03704389 | COMPLETED | NA

664 participants

Behavioral Economics Applications to Geriatrics Leveraging EHRs

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2019-01-17
Completion:: 2019-07-17

Conditions

Prostate Specific Antigen
Asymptomatic Bacteriuria
Type 2 Diabetes Mellitus

Interventions

BEHAVIORAL

Results Available

NCT03646214 | RECRUITING | NA

20 participants

Improving Sleep Quality During Pregnancy Using an Oral Appliance

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2018-02-01
Completion:: 2026-04-30

Conditions

Snoring
Sleep Fragmentation

Interventions

DEVICE

No Results Yet

NCT03603899 | COMPLETED | PHASE1/PHASE2

3 participants

Hp129 Xenon Imaging and BOS in Lung Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-09-09
Completion:: 2024-05-28

Conditions

Bronchiolitis Obliterans

Interventions

DRUG

No Results Yet

NCT03564691 | COMPLETED | PHASE1

470 participants

Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-4830-001)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2018-07-11
Completion:: 2025-09-26

Conditions

Neoplasms

Interventions

DRUG
BIOLOGICAL

No Results Yet

NCT03383094 | ACTIVE_NOT_RECRUITING | PHASE2

126 participants

Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2018-03-15
Completion:: 2026-12-31

Conditions

Head and Neck Squamous Cell Carcinoma
Cancer
Cancer of Head and Neck
Cancer, Advanced
Cancer, Metastatic
Tumor
Tumor Recurrence
Tumor Neck
Tumor Metastasis
Oral Cancer
Oropharyngeal Cancer
Oropharynx Cancer
Oropharynx Cancer, Stage III
Oropharynx Cancer, Recurrent
Oropharynx Cancer, Metastatic

Interventions

DRUG
RADIATION

No Results Yet

NCT03306173 | COMPLETED | NA

142 participants

COMET Study 1: Filter Ventilated Cigarette Substitution in the ETM

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2018-08-08
Completion:: 2020-03-10

Conditions

Substance-Related Disorders

Interventions

OTHER

Results Available

NCT03245541 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

18 participants

Radiation Therapy in Combination With Durvalumab for People With Pancreatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2020-08-14
Completion:: 2026-09-30

Conditions

Pancreatic Adenocarcinoma

Interventions

DRUG
RADIATION

No Results Yet

NCT03217058 | COMPLETED | NA

10821 participants

Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2016-08-01
Completion:: 2020-07-31

Conditions

Substance Use Disorders
HIV
Depression
Anxiety

Interventions

BEHAVIORAL

Results Available

NCT03033303 | COMPLETED | PHASE2

59 participants

A Study of the Effect of Hu3F8/GM-CSF Immunotherapy Plus Isotretinoin in Patients in First Remission of High-Risk Neuroblastoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2017-01-23
Completion:: 2025-09-29

Conditions

Neuroblastoma

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT03019471 | RECRUITING

40 participants

Non Invasive Cancer Test (NICT): a Proof of Principle Study.

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-07
Start Date:: 2016-03-01
Completion:: 2025-12-31

Conditions

Neoplasmata

Interventions

GENETIC

No Results Yet

NCT02970617 | COMPLETED | NA

82 participants

Ringing a Bell on the Final Day of Radiation Therapy in Improving the Memory of Distress in Cancer Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2016-08-15
Completion:: 2018-11-15

Conditions

Distress
Malignant Neoplasm

Interventions

OTHER

No Results Yet

NCT02969746 | WITHDRAWN | PHASE4

0 participants

Activates Charcoal for Patients Undergoing Invasive Procedure Delayed Due to Direct Oral Anticoagulants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2014-07-18
Completion:: 2018-09-30

Conditions

Anticoagulants; Circulating, Hemorrhagic Disorder

Interventions

DRUG

No Results Yet

NCT02917798 | ACTIVE_NOT_RECRUITING

1047 participants

Evaluating an Alternative Clinical Genetics Cancer Care Delivery Model: A Pilot Study of Patient Outcomes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-07
Start Date:: 2016-07-12
Completion:: 2026-09-30

Conditions

Ovarian Cancer
Prostate Cancer
Pancreas Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT02879812 | COMPLETED | NA

56332 participants

Disparities in National Kidney Allocation Policy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2016-09-30
Completion:: 2019-08-02

Conditions

Kidney Disorders

Interventions

OTHER

Results Available

NCT02621151 | ACTIVE_NOT_RECRUITING | PHASE2

60 participants

Pembrolizumab (MK3475), Gemcitabine, and Concurrent Hypofractionated Radiation Therapy for Muscle-Invasive Urothelial Cancer of the Bladder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2016-08-11
Completion:: 2022-11-10

Conditions

Muscle-invasive Urothelial Cancer of the Bladder

Interventions

BIOLOGICAL
PROCEDURE
DRUG
RADIATION

Results Available

NCT02586207 | COMPLETED | PHASE1

59 participants

Pembrolizumab in Combination With CRT for LA-SCCHN

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2015-11-30
Completion:: 2020-09-29

Conditions

Head and Neck Cancer
Squamous Cell Carcinoma
Oral Cavity Cancer
Oropharynx Cancer
Hypopharynx Cancer
Larynx Cancer
Laryngeal Cancer

Interventions

DRUG
RADIATION

Results Available

NCT02355184 | TERMINATED | PHASE2

20 participants

An Extension of Protocol PRO 140_CD01 Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2014-11-18
Completion:: 2022-06-30

Conditions

HIV
Human Immunodeficiency Virus

Interventions

DRUG

Results Available

NCT02285439 | COMPLETED | PHASE1/PHASE2

105 participants

Study of MEK162 for Children With Low-Grade Gliomas

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-07
Start Date:: 2016-05-04
Completion:: 2022-11-02

Conditions

Low-Grade Gliomas
Malignant Neoplasms, Brain
Soft Tissue Neoplasms

Interventions

DRUG

Results Available