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COMET Study 1: Filter Ventilated Cigarette Substitution in the ETM

NCT03306173 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 142

Last updated 2025-10-07

Study results available
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Summary

Early attempts by the tobacco industry to develop "safer" cigarettes led to the widespread introduction of ventilation holes in cigarette filters; however, this design feature may instead increase smoking-related harm and make cigarettes more palatable. The overall goal of this project is to model regulatory restrictions banning cigarette filter ventilation and determine their effects on consumption of both cigarettes and a wide range of alternative tobacco products. Testing potential regulatory actions under controlled conditions will facilitate evidence-based policies that have a net benefit to health.

Conditions

  • Substance-Related Disorders

Interventions

OTHER

Commercially available cigarette

Commercially available cigarette with either \~0% or \~25% filter ventilation. Menthol flavor will be available in both types.

Sponsors & Collaborators

  • University of Minnesota

    collaborator OTHER

  • National Cancer Institute (NCI)

    collaborator NIH

  • Virginia Polytechnic Institute and State University

    lead OTHER

Principal Investigators

  • Warren K Bickel, PHD · Fralin Biomedical Research Institute at VTC

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-08-08
Primary Completion
2020-03-10
Completion
2020-03-10

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03306173 on ClinicalTrials.gov