Clinical Trials Updated in 2025

NCT05018338 | TERMINATED

1 participants

Brain-Shift Monitoring Using 3D Scanning

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-02-28
Completion:: 2020-02-28

Conditions

Craniotomy for Epilepsy and Malignant Tumor Removal

Interventions

DEVICE

No Results Yet

NCT04986033 | COMPLETED

135 participants

Association Between Vitamin D and Perioperative Hemoglobin Levels in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery: Role of Hepcidin

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-08-01
Completion:: 2024-07-15

Conditions

Coronary Artery Disease

No Results Yet

NCT04985604 | TERMINATED | PHASE2

23 participants

Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-07-15
Completion:: 2024-07-08

Conditions

Melanoma
Solid Tumor
CRAF Gene Amplification
RAF1 Gene Amplification
BRAF Gene Fusion
BRAF Fusion
CRAF Gene Fusion
CRAF Fusion
RAF1 Gene Fusion
RAF1 Fusion
Thyroid Cancer, Papillary
Spitzoid Melanoma
Pilocytic Astrocytoma
Pilocytic Astrocytoma, Adult
Non Small Cell Lung Cancer
Non-Small Cell Adenocarcinoma
Colorectal Cancer
Pancreatic Acinar Carcinoma
Spitzoid Malignant Melanoma
Bladder Cancer
Bladder Urothelial Carcinoma
MAP Kinase Family Gene Mutation
RAF Mutation

Interventions

DRUG

Results Available

NCT04978558 | COMPLETED

509 participants

NIRS vs TCD for Cerebrovascular Autoregulation During Non-cardiac Surgery

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-08-09
Completion:: 2023-09-29

Conditions

Cerebrovascular Circulation

Interventions

OTHER

No Results Yet

NCT04976335 | RECRUITING | NA

50 participants

Quantitative and Clinical Assessment of Flexor Tendon Gliding Following Application of a Bioresorbable Hydrogel: A Prospective, Randomized Study in Patients Undergoing Distal Radius Fracture Repair

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-09-13
Completion:: 2027-07-31

Conditions

Distal Radius Fracture
Tendon Rupture

Interventions

DEVICE

No Results Yet

NCT04914897 | TERMINATED | PHASE2

106 participants

A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Lung Cancer or Mesothelioma (Pegathor Lung 202)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-09-23
Completion:: 2023-07-18

Conditions

Pleural Mesothelioma
Non-small Cell Lung Cancer

Interventions

DRUG

Results Available

NCT04913155 | ACTIVE_NOT_RECRUITING | NA

12100 participants

HANSE - Holistic Implementation Study Assessing a Northern German Interdisciplinary Lung Cancer Screening Effort

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-05-20
Completion:: 2024-03-01

Conditions

Lung Cancer

Interventions

RADIATION

No Results Yet

NCT04892745 | COMPLETED

18 participants

Impact of Hemodialysis on Cutaneo-muscular Electrical Impedance

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-09-29
Completion:: 2022-05-25

Conditions

Hemodialysis

No Results Yet

NCT04863729 | COMPLETED | NA

408 participants

Evaluation of Asdzáán Be'eená Teen Pregnancy and Substance Use Prevention Program for Native American Youth and Their Caregiver

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-05-20
Completion:: 2025-09-29

Conditions

Sex Behavior

Interventions

BEHAVIORAL

No Results Yet

NCT04816994 | RECRUITING | PHASE3

200 participants

Effect of Cannabis Extract on Acute Radicular Pain and on Analgesic Requirement

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2018-01-07
Completion:: 2025-12-31

Conditions

Acute Radicular Back Pain
Cannabis

Interventions

DRUG

No Results Yet

NCT04736004 | TERMINATED

1 participants

Hearts of Athletes

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2022-11-03
Completion:: 2025-09-24

Conditions

Cardiac Involvement With COVID-19

No Results Yet

NCT04662970 | RECRUITING | NA

25 participants

Optimization of Cardiac Resynchronization Therapy by Non-Invasive Imaging of Cardiac Electrophysiology

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-01-01
Completion:: 2027-12-31

Conditions

Heart Failure

Interventions

DEVICE

No Results Yet

NCT04658628 | RECRUITING

42 participants

Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-01-22
Completion:: 2027-11-30

Conditions

Chronic Low-back Pain

No Results Yet

NCT04623398 | COMPLETED | PHASE3

22 participants

Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2022-02-21
Completion:: 2024-08-26

Conditions

Autism Spectrum Disorder

Interventions

DRUG

No Results Yet

NCT04581499 | COMPLETED | NA

236 participants

Tech-Enabled CM for AUD at Scale

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-01-01
Completion:: 2025-01-01

Conditions

Alcohol Use Disorder
Alcohol Dependence
Drug Dependence

Interventions

COMBINATION_PRODUCT
OTHER

No Results Yet

NCT04551053 | TERMINATED | PHASE3

177 participants

To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-05-26
Completion:: 2023-08-16

Conditions

Myelofibrosis
Primary Myelofibrosis
Post Essential Thrombocythemia Myelofibrosis
Post Polycythemia Vera Myelofibrosis

Interventions

DRUG

Results Available

NCT04529941 | COMPLETED | NA

46 participants

Using Electrical Nerve Stimulation to Control Atrial Fibrillation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-11-24
Completion:: 2024-09-04

Conditions

Atrial Fibrillation

Interventions

DEVICE

Results Available

NCT04501614 | TERMINATED | PHASE1/PHASE2

11 participants

A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-02-24
Completion:: 2023-12-19

Conditions

Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL)
Ph+ Mixed Phenotype Acute Leukemia (MPAL)
Philadelphia Chromosome-Like ALL (Ph-like ALL)

Interventions

DRUG

Results Available

NCT04495556 | ACTIVE_NOT_RECRUITING

420 participants

Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-06-11
Completion:: 2027-01-31

Conditions

Multiple Sclerosis

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04466345 | COMPLETED | PHASE2

72 participants

Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-10-06
Completion:: 2024-12-27

Conditions

Major Depressive Disorder

Interventions

BIOLOGICAL

No Results Yet

NCT04451668 | COMPLETED | PHASE3

184 participants

An Open Label Study of FT218 in Subjects With Narcolepsy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-06-12
Completion:: 2023-12-22

Conditions

Narcolepsy
Cataplexy
Excessive Daytime Somnolence
Sleep Disorder
Sleep Disturbance
Sleep Wake Disorders

Interventions

DRUG

No Results Yet

NCT04366115 | NOT_YET_RECRUITING | PHASE1

16 participants

Evaluating AVM0703 for Treatment of COVID-19 or Influenza-mediated ARDS

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2026-12-01
Completion:: 2031-12-01

Conditions

ARDS
Covid19
Influenza, Human

Interventions

DRUG

No Results Yet

NCT04343807 | COMPLETED | NA

70 participants

Effectiveness of Ultrasound Guided PECS Block on Opioid Consumption and Patient Satisfaction Through Adequate Pain Control Following Breast Cancer Surgery.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2023-11-01
Completion:: 2024-12-30

Conditions

Breast Neoplasm Female
Pain, Postoperative
Pain
Analgesia
Anaesthesia
Breast Cancer

Interventions

PROCEDURE
OTHER

No Results Yet

NCT04305613 | ACTIVE_NOT_RECRUITING

221 participants

Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-09-14
Completion:: 2026-09-30

Conditions

Cardiotoxicity
Lung Cancer Stage III
Lung Cancer Stage II
Radiation Toxicity

Interventions

OTHER

No Results Yet

NCT04298125 | RECRUITING | NA

60 participants

Community Translation of the Expecting Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-07-16
Completion:: 2026-06-30

Conditions

Pregnancy Related

Interventions

BEHAVIORAL

No Results Yet

NCT04273243 | ACTIVE_NOT_RECRUITING

10 participants

Long-Term Follow Up of CLN6 Batten Disease Subjects Following Gene Transfer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-01-24
Completion:: 2026-12-31

Conditions

CLN6
Batten Disease

Interventions

GENETIC

No Results Yet

NCT04250766 | ACTIVE_NOT_RECRUITING | NA

19 participants

Diagnostic Performances of Preoperative Echo-guided Uterine Biopsy in the Management of Suspect Uterine Sarcoma Tumors (BIOPSAR)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-09-07
Completion:: 2026-06-30

Conditions

Fibroid Uterus
Sarcoma Uterus

Interventions

PROCEDURE

No Results Yet

NCT04206436 | ACTIVE_NOT_RECRUITING

63 participants

CFTR Modulator Effects on Bone and Muscle in Adults With Cystic Fibrosis

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2019-12-18
Completion:: 2027-12-31

Conditions

Cystic Fibrosis
Bone Loss
Muscle Loss

Interventions

DRUG

No Results Yet

NCT04206397 | COMPLETED | NA

80 participants

Mechanisms of Affective Touch in Chronic Pain

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-09-15
Completion:: 2024-10-21

Conditions

Fibromyalgia

Interventions

BEHAVIORAL

Results Available

NCT04198428 | COMPLETED | NA

10891 participants

Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2019-11-12
Completion:: 2023-12-31

Conditions

Opioid-use Disorder

Interventions

OTHER

Results Available

NCT04188912 | COMPLETED

267 participants

Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2019-09-13
Completion:: 2025-09-29

Conditions

Hematopoietic and Lymphoid Cell Neoplasm

Interventions

PROCEDURE
OTHER

No Results Yet

NCT04168216 | COMPLETED

31 participants

Study of Relationship Between Changes in Inflammation, Lung Function, Symptoms and Medication Use in COPD Patients

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-11-30
Completion:: 2022-06-22

Conditions

Pulmonary Disease, Chronic Obstructive

No Results Yet

NCT04098744 | RECRUITING | PHASE2

78 participants

Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-09-09
Completion:: 2026-07-31

Conditions

CIN 2/3
HPV Infection
Pre-Cancerous Dysplasia
Cervical Dysplasia
HPV Related Disease

Interventions

DRUG

No Results Yet

NCT04063670 | COMPLETED | NA

40 participants

Coping After Pediatric Scoliosis Surgery

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2019-05-01
Completion:: 2021-06-01

Conditions

Adolescent Idiopathic Scoliosis

Interventions

OTHER

No Results Yet

NCT04059640 | ACTIVE_NOT_RECRUITING | NA

109 participants

PMCF Study of LiquiBand FIX8® OHMF Device

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2021-12-07
Completion:: 2025-07-31

Conditions

Inguinal Hernia

Interventions

DEVICE

No Results Yet

NCT04049357 | COMPLETED | NA

2031 participants

Care for Colon 2015

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-08-03
Completion:: 2024-01-31

Conditions

Colorectal Cancer
Adenoma

Interventions

DEVICE

No Results Yet

NCT04016415 | COMPLETED | NA

309 participants

Decreasing Stress in Diabetes

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2020-07-28
Completion:: 2024-08-09

Conditions

Stress
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 1

Interventions

BEHAVIORAL

Results Available

NCT03957707 | ACTIVE_NOT_RECRUITING | NA

380 participants

Sterotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2019-01-01
Completion:: 2025-10-31

Conditions

Basal Ganglia Haematoma

Interventions

PROCEDURE

No Results Yet

NCT03833934 | COMPLETED

62 participants

Study of Plasma NGS for Assessment, Characterization, Evaluation of Patients With ALK Resistance

Study Type:: OBSERVATIONAL
Last Updated:: 2025-10-02
Start Date:: 2019-01-23
Completion:: 2023-10-31

Conditions

Non-Small Cell Lung Cancer

Results Available

NCT03805022 | RECRUITING | PHASE3

351 participants

Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas

Study Type:: INTERVENTIONAL
Last Updated:: 2025-10-02
Start Date:: 2019-02-14
Completion:: 2026-12-31

Conditions

Non-metastatic Soft-tissue Sarcoma
Resectable

Interventions

DRUG

No Results Yet