Sterotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation

Summary

Spontaneous cerebral hemorrhage is one of the main causes of death and disability all over the world, accounting for 20%-30% of all cerebrovascular diseases. Minimally invasive surgery of cerebral hemorrhage, especially puncture aspiration, can improve early and long-term neurological recovery in patients with cerebral hemorrhage. Until now, no standardized practice for minimally invasive surgery of spontaneous cerebral hemorrhage has been established. Hematoma puncture and drainage based on CT scans without precise localization and personalized approach design, which may lead to poor efficacy and high risk of complications. Our hospital has much experience in treating cerebral hemorrhage with stereotactic puncture and aspiration. So we conduct a prospective multicenter randomized controlled clinical trial to determine the therapeutic effects of puncture aspiration plus thrombolysis treatment for the perioperative and long-term recovery of patients with small to moderate hematoma in deep basal ganglia via computerized precision coordinates and personalized approach design.

Conditions

• Basal Ganglia Haematoma

Interventions

PROCEDURE

stereotactic surgery plus thrombolysis

stereotactic puncture and aspiration to evacuate basal ganglion hematoma with or without thrombolytic agent

Sponsors & Collaborators

• Sir Run Run Shaw Hospital

  collaborator OTHER

• Ningbo No. 1 Hospital

  collaborator OTHER

• Ningbo Medical Center Lihuili Hospital

  collaborator OTHER_GOV

• Second Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Affiliated Wenling Hospital of Wenzhou Medical University

  collaborator OTHER

• Zhuji People's Hospital of Zhejiang Province

  collaborator OTHER

• Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

  collaborator OTHER

• Jinhua Central Hospital

  collaborator OTHER

• Huzhou Central Hospital

  collaborator OTHER

• People's Hospital of Quzhou

  collaborator OTHER

• The Sixth Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• The Second Affiliated Hospital of Jiaxing University

  collaborator OTHER

• Xiaoshan Hospital

  collaborator UNKNOWN

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-01-01

Primary Completion

2025-10-31

Completion

2025-10-31

Countries

• China

Study Locations